Analysis of clinical features of non-epileptic psychotic seizures in Tibetan population_Journal of Epilepsy

Authors：

HE Shihua ^1,2 , ZHUO Ma ² ,  ZHAO Yuhua ^1,2 , DING Zhijie ² , HAO Yu ²

1. School of Medicine, Tibet University, Lhasa 850000, China;
2. Department of Neurology, the People’s Hospital of Tibet Autonomous Region (TAR), Lhasa, Lhasa 850000, China;

Corresponding author：

ZHAO Yuhua, Email: drolyang@163.com

Keywords：

Tibet; Psychogenic non-epileptic seizures; Clinical features

DOI：

10.7507/2096-0247.20190071

Video：

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Objective To analyze the clinical features of psychogenic non-epileptic seizures (Psychogenic nonepileptic seizures, PNES) in Tibetan population in Tibet, so as to help clinicians identify the disease.Methods Retrospective analyzed the clinical data of patients with PNES in the Department of Neurology, People's Hospital of Tibet Autonomous Region from June 2016 to December 2018.Results In general clinical data, there were significant differences between male and female patients in the results of video electroencephalogram (EEG) monitoring the non-epileptic seizures (P< 0.05). There were no significant differences in mean age, mean onset time, family history of epilepsy, head injury and marital status between male and female patients (P> 0.05). There was no significant difference in symptoms between male and female, but there were differences among different age groups (P> 0.05). In the onset age, the main manifestation was young women, but there was no significant difference in the onset of PNES among different age groups.Conclusions There was significant differences between male and female PNES petients, but no significant differences in onset time, marriage and family history of epilepsy between the male and female patients with PNES in Tibet. The clinical manifestations of PNES were different in different ages of patients in Tibet.

Citation： HE Shihua, ZHUO Ma, ZHAO Yuhua, DING Zhijie, HAO Yu. Analysis of clinical features of non-epileptic psychotic seizures in Tibetan population. Journal of Epilepsy, 2019, 5(6): 445-449. doi: 10.7507/2096-0247.20190071 Copy

1.	Pourkalbassi D, Patel P. Conversion disorder: The brain's way of dealing with psychological conflicts case rport of a patient with non-epileptic seizures. Cureus, 2019, 11(1): e3902.
2.	Benbadis SR. Psychogenic nonepileptic seizures, conversion, and somatic symptom disorders. Neurology, 2019, 92(7): 1-2.
3.	Auxéméry Y, Hubsch C. Psychogenic non epileptic seizures:a review. Encep-hale, 2011, 37(2): 153-158.
4.	Bodde NM, Brooks JL, Baker GA, et al. Psychogenic non-epileptic seizures–definition, etiology, treatment and prognostic issues: a critical review. Seizure, 2009, 18(8): 543-553.
5.	Indranada AM, Mullen SA, Wong MJ, et al. Preictal autonomic dynamics in psychogenic nonepileptic seizures. Epilepsy Behav, 2019, 92: 206-212.
6.	Magaudda A, Laganà A, Calamuneri A, et al. Validation of a novel classification model of psychogenic nonepileptic seizures by video-EEG analysis and a machine learning approach. Epilepsy Behav, 2016, 60: 197-201.
7.	Duncan R, Razvi S, Mulhern S. Newly presenting psychogenic nonepileptic seizures: incidence, population characteristics, and early outcome from a prospective audit of a first seizure clinic. Epilepsy Behav, 2011, 20(2): 308-311.
8.	Reif PS, Willems LM, Strzelczyk A, et al. Psychogenic non epileptic seizures : differential diagnostic features. Herzschrittmacherther Elektrophysiol, 2018, 29: 155-160.
9.	Méndez-Ruiz JM, Martínez-Taboas A, Valdez-Pimentel YM, et al. Clinical profile of patients with psychogenic non-epileptic seizures in Puerto Rico. P R Health Sci J, 2017, 36(3): 212-217.
10.	赵永青, 丁成赟, 李志梅, 等. 心因性发作 32 例临床分析. 中风与神经疾病杂志, 2007, 24(3): 326-328.
11.	Kutlubaev MA, Xu Y, Hackett ML. Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: systematic review and meta-analysis of frequency, correlates, and outcomes. Epilepsy Behav, 2018, 89: 70-78.
12.	Tolchin B, Dworetzky BA. Long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures. Epilepsia, 2018, 59(1): 18-22.
13.	Asadi-Pooya AA, Tinker J. Semiological classification of psychogenic nonepileptic seizures. Epilepsy Behav, 2016, 64: 1-3.
14.	Milán-Tomás Á, Persyko M, Del Campo M, et al. An overview of psychogenic non-epileptic seizures: etiology, diagnosis and management. Can J Neurol Sci, 2018, 45(1): 130-136.
15.	吴立文主审, 任连坤主译. 癫痫发作和综合征的诊断与治疗(第 1 版). 北京: 中国协和医科大学出版社, 2008: 4-5.
16.	Reif PS, Willems LM, Strzelczyk A, et al. Psychogenic non epileptic seizures : differential diagnostic features. Herzschrittmacher therapie & Elektrophysiologie, 2018, 29(2): 155-160.
17.	Chen DK, Sharma E. Psychogenic non-epileptic seizures. Current neurology and neuroscience reports, 2017, 17(9): 71.
18.	陈波, 周东, 徐鸿儒, 等. 心因性非癫痫性发作时的症状学研究. 四川大学学报 (医学版), 2007, (4): 748-749+752.
19.	张国珧. 综合医院 257 例急诊癔症的临床分析. 中国现代药物应用, 2008, (24): 113-114.
20.	梅桂森. 转换障碍 87 例临床分析. 中国中西医结合学会精神疾病专业委员会第十届学术会议论文集.中国中西医结合学会精神疾病专业委员会: 中国中西医结合学会, 2010: 3.
21.	Dworetzky BA. Psychogenic nonepileptic seizures in women. Semin Neurol, 2017, 37: 624-631.
22.	Kerr WT, Janio EA, Braesch CT, et al. An objective score to identify psychogenic seizures based on age of onset and history. Epilepsy Behav, 2018, 80: 75-83.
23.	Brown RJ, Reuber M. Towards an integrative theory of psychogenic non-epileptic seizures (PNES). Clin Psychol Rev, 2016, 47(7): 55-70.
24.	Reuber M. Understanding psychogenic nonepileptic seizures-Phenomenology, semiology and the Integrative Cognitive Model. Seizure, 2017, 44(5): 199-205.
25.	Asadi-Pooya AA, Tinker J. How variable are psychogenic nonepileptic seizures?. A retrospective semiological study. J Neurol Sci, 2017, 377(4): 85-87.
26.	Asadi-Pooya AA, AlBaradie R, Sawchuk T, et al. Psychogenic nonepileptic seizures in children and adolescents: an international cross-cultural study. Epilepsy Behav, 2019, 90: 90-92.
27.	Korucuk M, Gazioglu S, Yildirim A, et al. Semiological characteristics of patients with psychogenic nonepileptic seizures: gender-related differences. Epilepsy Behav, 2018, 89: 130-134.

1. Pourkalbassi D, Patel P. Conversion disorder: The brain's way of dealing with psychological conflicts case rport of a patient with non-epileptic seizures. Cureus, 2019, 11(1): e3902.
2. Benbadis SR. Psychogenic nonepileptic seizures, conversion, and somatic symptom disorders. Neurology, 2019, 92(7): 1-2.
3. Auxéméry Y, Hubsch C. Psychogenic non epileptic seizures:a review. Encep-hale, 2011, 37(2): 153-158.
4. Bodde NM, Brooks JL, Baker GA, et al. Psychogenic non-epileptic seizures–definition, etiology, treatment and prognostic issues: a critical review. Seizure, 2009, 18(8): 543-553.
5. Indranada AM, Mullen SA, Wong MJ, et al. Preictal autonomic dynamics in psychogenic nonepileptic seizures. Epilepsy Behav, 2019, 92: 206-212.
6. Magaudda A, Laganà A, Calamuneri A, et al. Validation of a novel classification model of psychogenic nonepileptic seizures by video-EEG analysis and a machine learning approach. Epilepsy Behav, 2016, 60: 197-201.
7. Duncan R, Razvi S, Mulhern S. Newly presenting psychogenic nonepileptic seizures: incidence, population characteristics, and early outcome from a prospective audit of a first seizure clinic. Epilepsy Behav, 2011, 20(2): 308-311.
8. Reif PS, Willems LM, Strzelczyk A, et al. Psychogenic non epileptic seizures : differential diagnostic features. Herzschrittmacherther Elektrophysiol, 2018, 29: 155-160.
9. Méndez-Ruiz JM, Martínez-Taboas A, Valdez-Pimentel YM, et al. Clinical profile of patients with psychogenic non-epileptic seizures in Puerto Rico. P R Health Sci J, 2017, 36(3): 212-217.
10. 赵永青, 丁成赟, 李志梅, 等. 心因性发作 32 例临床分析. 中风与神经疾病杂志, 2007, 24(3): 326-328.
11. Kutlubaev MA, Xu Y, Hackett ML. Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: systematic review and meta-analysis of frequency, correlates, and outcomes. Epilepsy Behav, 2018, 89: 70-78.
12. Tolchin B, Dworetzky BA. Long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures. Epilepsia, 2018, 59(1): 18-22.
13. Asadi-Pooya AA, Tinker J. Semiological classification of psychogenic nonepileptic seizures. Epilepsy Behav, 2016, 64: 1-3.
14. Milán-Tomás Á, Persyko M, Del Campo M, et al. An overview of psychogenic non-epileptic seizures: etiology, diagnosis and management. Can J Neurol Sci, 2018, 45(1): 130-136.
15. 吴立文主审, 任连坤主译. 癫痫发作和综合征的诊断与治疗(第 1 版). 北京: 中国协和医科大学出版社, 2008: 4-5.
16. Reif PS, Willems LM, Strzelczyk A, et al. Psychogenic non epileptic seizures : differential diagnostic features. Herzschrittmacher therapie & Elektrophysiologie, 2018, 29(2): 155-160.
17. Chen DK, Sharma E. Psychogenic non-epileptic seizures. Current neurology and neuroscience reports, 2017, 17(9): 71.
18. 陈波, 周东, 徐鸿儒, 等. 心因性非癫痫性发作时的症状学研究. 四川大学学报 (医学版), 2007, (4): 748-749+752.
19. 张国珧. 综合医院 257 例急诊癔症的临床分析. 中国现代药物应用, 2008, (24): 113-114.
20. 梅桂森. 转换障碍 87 例临床分析. 中国中西医结合学会精神疾病专业委员会第十届学术会议论文集.中国中西医结合学会精神疾病专业委员会: 中国中西医结合学会, 2010: 3.
21. Dworetzky BA. Psychogenic nonepileptic seizures in women. Semin Neurol, 2017, 37: 624-631.
22. Kerr WT, Janio EA, Braesch CT, et al. An objective score to identify psychogenic seizures based on age of onset and history. Epilepsy Behav, 2018, 80: 75-83.
23. Brown RJ, Reuber M. Towards an integrative theory of psychogenic non-epileptic seizures (PNES). Clin Psychol Rev, 2016, 47(7): 55-70.
24. Reuber M. Understanding psychogenic nonepileptic seizures-Phenomenology, semiology and the Integrative Cognitive Model. Seizure, 2017, 44(5): 199-205.
25. Asadi-Pooya AA, Tinker J. How variable are psychogenic nonepileptic seizures?. A retrospective semiological study. J Neurol Sci, 2017, 377(4): 85-87.
26. Asadi-Pooya AA, AlBaradie R, Sawchuk T, et al. Psychogenic nonepileptic seizures in children and adolescents: an international cross-cultural study. Epilepsy Behav, 2019, 90: 90-92.
27. Korucuk M, Gazioglu S, Yildirim A, et al. Semiological characteristics of patients with psychogenic nonepileptic seizures: gender-related differences. Epilepsy Behav, 2018, 89: 130-134.

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