GUO Tao , WU Jiang , CHEN Yao , LIU Qianwei , LAN Yanqin
  • Department of Functional Neurosurgery, Hebei General Hospital, Shijiazhuang, China;
WU Jiang, Email: wujiang104@126.com
Morphine; Electroencephalogram; Ultramicro; Cat
10.7507/2096-0247.20200003
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Objective To analyze the effect of mitochondrial ultrastructural changes caused by morphine toxicity on abnormal discharge of cat cerebral cortex, and to explore the possible mechanism of brain function damage caused by morphine dependence.Methods Twelve domestic cats were divided into control group (3 cats) and morphine exposed group (9 cats) according to the method of random number table. After the model was successfully established by the method of dose increasing, the changes of mitochondrial ultrastructure of cortical neurons were observed under the electron microscope.Results Electroencephalogram (EEG) monitoring in morphine exposed group showed that the cortical EEG was widely abnormal, physiological waves were reduced, and abnormal discharges were frequent. And the electron microscopy showed that the number, morphology, internal membrane structure and the inclusion body in the matrix of neurons changed in various aspects. The EEG and electron microscopy of the control group were normal.Conclusion Morphine can damage neurons in the cerebral cortex and lead to abnormal discharge, which is closely related to the ultrastructural changes of neuron mitochondria. The toxicity of morphine mitochondria can be the initial mechanism of energy metabolism dysfunction of brain cells and eventually lead to the disorder of brain electrophysiological function.

Citation： GUO Tao, WU Jiang, CHEN Yao, LIU Qianwei, LAN Yanqin. The study of morphine mitochondrial toxicity impact on cat electroencephalogram. Journal of Epilepsy, 2020, 6(1): 12-15. doi: 10.7507/2096-0247.20200003 Copy

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