癫痫持续状态长期结局：一项关键评价_Journal of Epilepsy

Authors：

 SculierC , Gaínza-LeinM , Sánchez FernándezI , 李思思　译 , 童馨　慕洁　审

Corresponding author：

SculierC, Email: tobias.loddenkemper@childrens.harvard.edu

Keywords：

认知结果; 癫痫; 功能损害; 死亡率; 神经后遗症; 生活质量

DOI：

10.7507/2096-0247.20200011

Video：

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Abstract Full text Figures/Tables Video References Cited by

回顾性分析 37 项关于儿童和成人癫痫持续状态（Status epilepticus, SE）长期结果的研究，总结其研究设计、随访时间、结果评估、调查地区（死亡率、SE 复发、继发性癫痫、认知结果、功能结果或生活质量）以及长期预后的预测因素。尽管既往研究设计存在异质性，儿童和成人在 SE 后长期不良结局的总体风险均很高。病因是影响结局的主要因素，年龄或 SE 持续时间的影响往往难以与潜在病因区分开来。治疗对 SE 远期疗效的影响尚不清楚。

Citation： SculierC, Gaínza-LeinM, Sánchez FernándezI, 李思思　译, 童馨　慕洁　审. 癫痫持续状态长期结局：一项关键评价. Journal of Epilepsy, 2020, 6(1): 53-62. doi: 10.7507/2096-0247.20200011 Copy

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1. Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care, 2012, 17(1): 3-23.
2. Glauser T, Shinnar S, Gloss D, et al. Evidence‐based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr, 2016, 16(1): 48-61.
3. Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr, 2014, 26(3): 668-674.
4. Raspall-Chaure M, Chin RFM, Neville BG, et al. Outcome of paediatric convulsive status epilepticus: a systematic review. Lancet Neurol, 2006, 5(Suppl): 769-779.
5. Ferro MA, Chin RFM, Camfield CS, et al. Convulsive status epilepticus and health‐related quality of life in children with epilepsy. Neurology, 2014, 83(4): 752-757.
6. Metsäranta P, Koivikko M, Peltola J, et al. Outcome after prolonged convulsive seizures in 186 children: low morbidity, no mortality. Dev Med Child Neurol, 2004, 46(1): 4-8.
7. Hesdorffer DC, Logroscino G, Cascino G, et al. Incidence of status epilepticus in rochester, minnesota, 1965‐1984. Neurology, 1998, 50(4): 735-741.
8. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population‐based epidemiologic study of status epilepticus in richmond. Virginia Neurology, 1996, 46(8): 1029-1035.
9. Hesdorffer DC, Logroscino G, Cascino GD, et al. Recurrence of afebrile status epilepticus in a population‐based study in rochester, minnesota. Neurology, 2007, 69(1): 73-78.
10. Adachi N, Kanemoto K, Muramatsu R, et al. Intellectual prognosis of status epilepticus in adult epilepsy patients: analysis with Wechsler Adult Intelligence Scale‐revised. Epilepsia, 2005, 46(Suppl 2): 1502-1509.
11. Logroscino G, Hesdorffer DC, Cascino G, et al. Status epilepticus without an underlying cause and risk of death: a population‐based study. Arch Neurol, 2008, 65(2): 221-224.
12. Ristić AJ, Sokić DV, Trajković G, et al. Long‐term survival in patients with status epilepticus: a tertiary referral center study. Epilepsia, 2010, 51(1): 57-61.
13. DeLorenzo RJ, Towne AR, Pellock JM, et al. Status epilepticus in children, adults, and the elderly. Epilepsia, 1992, 33(Suppl 4): 15-25.
14. Holtkamp M, Othman J, Buchheim K, et al. Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry, 2005, 76(4): 534-539.
15. Cooper AD, Britton JW, Rabinstein AA. Functional and cognitive outcome in prolonged refractory status epilepticus. Arch Neurol, 2009, 66(Suppl): 1505-1509.
16. Jayalakshmi S, Ruikar D, Vooturi S, et al. Determinants and predictors of outcome in super refractory status epilepticus-a developing country perspective. Epilepsy Res, 2014, 108(12): 1609-1617.
17. Maegaki Y, Kurozawa Y, Hanaki K, et al. Risk factors for fatality and neurological sequelae after status epilepticus in children. Neuropediatrics, 2005, 36(2): 186-192.
18. Kortland LM, Knake S, von Podewils F, et al. Socioeconomic outcome and quality of life in adults after status epilepticus: a multicenter, longitudinal, matched case‐control analysis from germany. Front Neurol, 2017, 8(4): 507.
19. Atmaca MM, Bebek N, Baykan B, et al. Predictors of outcomes and refractoriness in status epilepticus: a prospective study. Epilepsy Behav, 2017, 75: 158-164.
20. Legriel S, Azoulay E, Resche-Rigon M, et al. Functional outcome after convulsive status epilepticus. Crit Care Med, 2010, 38(5): 2295-2303.
21. Kilbride RD, Reynolds AS, Szaflarski JP, et al. Clinical outcomes following prolonged refractory status epilepticus (PRSE). Neurocrit Care, 2013, 18(3): 374-385.
22. Erklauer JO, Wilfong A, Jeanine G. Outcome in refractory and super‐refractory status epilepticus in children. Neurocrit Care, 2016, 25(Suppl 1): 1-310.
23. Li Y, Tian L, Zeng T, et al. Clinical features and outcome of super‐refractory status epilepticus: a retrospective analysis in west China. Seizure, 2014, 23(6): 722-727.
24. Kim SJ, Lee DY, Kim JS. Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. Pediatr Neurol, 2001, 25(2): 217-220.
25. Loddenkemper T, Goodkin HP. Treatment of pediatric status epilepticus. Curr Treat Options Neurol, 2011, 13(4): 560-573.
26. Maytal J, Shinnar S, Moshé SL, et al. Low morbidity and mortality of status epilepticus in children. Pediatrics, 1989, 83(3): 323-331.
27. Eriksson KJ, Koivikko MJ. Status epilepticus in children: aetiology, treatment, and outcome. Dev Med Child Neurol, 1997, 39(5): 652-658.
28. Barnard C, Wirrell E. Does status epilepticus in children cause developmental deterioration and exacerbation of epilepsy? J Child Neurol, 1999, 14(5): 787-794.
29. Hussain N, Appleton R, Thorburn K. Aetiology, course and outcome of children admitted to paediatric intensive care with convulsive status epilepticus: a retrospective 5‐year review. Seizure, 2007, 16(2): 305-312.
30. Hesdorffer DC, Logroscino G, Cascino G, et al. Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol, 1998, 44(7): 908-912.
31. Shinnar S, Berg AT, Moshe SL, et al. The risk of seizure recurrence after a first unprovoked afebrile seizure in childhood: an extended follow‐up. Pediatrics, 1996, 98(2): 216-225.
32. Berg AT. Risk of recurrence after a first unprovoked seizure. Epilepsia, 2008, 49(Suppl 1): 13-18.
33. Camfield P, Camfield C. Unprovoked status epilepticus: the prognosis for otherwise normal children with focal epilepsy. Pediatrics, 2012, 130(4): 501-506.
34. Sillanpää M, Shinnar S. Status epilepticus in a population‐based cohort with childhood‐onset epilepsy in Finland. Ann Neurol, 2002, 52(3): 303-310.
35. Shinnar S, Maytal J, Krasnoff L, et al. Recurrent status epilepticus in children. Ann Neurol, 1992, 31(5): 598-604.
36. Tabarki B, Yacoub M, Selmi H, et al. Infantile status epilepticus in Tunisia. Clinical, etiological and prognostic aspects. Seizure, 2001, 10(2): 365-369.
37. Martinos MM, Yoong M, Patil S, et al. Early developmental outcomes in children following convulsive status epilepticus: a longitudinal study. Epilepsia, 2013, 54(Suppl 1): 1012-1019.
38. Chevrie JJ, Aicardi J. Convulsive disorders in the first year of life: neurological and mental outcome and mortality. Epilepsia, 1978, 19(1): 67-74.
39. Hermann BP, Seidenberg M, Dow C, et al. Cognitive prognosis in chronic temporal lobe epilepsy. Ann Neurol, 2006, 60(1): 80-87.
40. De Marchis GM, Pugin D, Meyers E, et al. Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome. Neurology, 2016, 86(2): 253-260.
41. Holmes GL. Effects of early seizures on later behavior and epileptogenicity. Ment Retard Dev Disabil Res Rev, 2004, 10(1): 101-105.
42. Deshpande LS, Lou JK, Mian A, et al. In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Res, 2007, 75(2): 171-179.
43. Legriel S, Lemiale V, Schenck M, et al. Hypothermia for neuroprotection in convulsive status epilepticus. N Engl J Med, 2016, 375(12): 2457-2467.
44. Madžar D, Geyer A, Knappe RU, et al. Association of seizure duration and outcome in refractory status epilepticus. J Neurol, 2016, 263(3): 485-491.
45. Wagenman KL, Blake TP, Sanchez SM, et al. Electrographic status epilepticus and long‐term outcome in critically ill children. Neurology, 2014, 82(2): 396-404.
46. Krumholz A, Sung GY, Fisher RS, et al. Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology, 1995, 63(12): 1499-1504.
47. Berg AT, Shinnar S, Testa FM, et al. Status epilepticus after the initial diagnosis of epilepsy in children. Neurology, 2004, 72(10): 1027-1034.
48. Chin RFM, Neville BGR, Peckham C, et al. Incidence, cause, and short‐term outcome of convulsive status epilepticus in childhood: prospective population‐based study. Lancet, 2006, 368(1): 222-229.
49. Singh RK, Stephens S, Berl MM, et al. Prospective study of new‐onset seizures presenting as status epilepticus in childhood. Neurology, 2010, 74(4): 636-642.
50. Vignatelli L, Tonon C, D'Alessandro R, et al. Incidence and short‐term prognosis of status epilepticus in adults in Bologna, Italy. Epilepsia, 2003, 44(5): 964-968.
51. Loddenkemper T, Syed TU, Ramgopal S, et al. Risk factors associated with death in in‐hospital pediatric convulsive status epilepticus. PLoS One, 2012, 7: e47474.
52. Lv RJ, Wang Q, Cui T, et al. Status epilepticus‐related etiology, incidence and mortality: a meta‐analysis. Epilepsy Res, 2017, 136(1): 12-17.
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Journal of Epilepsy

癫痫持续状态长期结局：一项关键评价

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