Observation of clinical effects of Lacosamide addition therapy in children with refractory epilepsy_Journal of Epilepsy

Authors：

FENG Jie ,  GAO LI , LI Yan , FAN Hongye , QI Hui , YANG Liu

Department of Neurology, General Hospital of Henan Province, Zhengzhou 453003, China;

Corresponding author：

GAO LI, Email: 1879872583@qq.com

Keywords：

Intractable epilepsy; Lacosamine; Children; Observation on clinical efficacy

DOI：

10.7507/2096-0247.20200017

Video：

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Objective To observe the clinical effect of Lacosamide (LCM) in the treatment of children with intractable epilepsy.Methods 41 cases of refractory epilepsy patients who received LCM from March to July 2019 in department of Neurology, General Hospital of Henan Province were collected which included 21 males, 20 females, age were 4.6 ~ 15.5 years, average (7.21±3.06) years, And the efficacy of LCM was observed through blank control study.Results After LCM was added to the blank self-control group, the frequency of epileptic seizures was significantly reduced during the follow-up period of 3 months and 6 months, with statistically significant difference (P<0.05), and the mental state of the children was effectively improved, but there was no statistical significance between focal refractory epileptic seizure and comprehensive refractory epileptic seizure (P>0.05).Conclusions LCM is a new kind of the third generation of antiepileptic drug. The addition use of LCM can effectively reduce the seizure frequency and improve mental state in children with refractory epilepsy.

Citation： FENG Jie, GAO LI, LI Yan, FAN Hongye, QI Hui, YANG Liu. Observation of clinical effects of Lacosamide addition therapy in children with refractory epilepsy. Journal of Epilepsy, 2020, 6(2): 98-101. doi: 10.7507/2096-0247.20200017 Copy

1.	Hirtz D, Thurman DJ, Gwinn-Hardy K, et al. How common are the common neurologic disorders? Neurology, 2007, 68(5): 326-337.
2.	Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med, 1996, 334(3): 168-175.
3.	Giráldez BG, Toledano R, García-morales I, et al. Long-term efficacy and safety of lacosamide monotherapy in the treatment of partial-onset seizures: A multicenter evaluation. Seizure, 2015, 29(1): 119-122.
4.	Cawello W, Stockis A, Andreas JO, et al. Advances in epilepsy treatment: lacosamide pharmacokinetic profle. Ann NY Acad Sci, 2014, 1329(1): 18-32.
5.	中华医学会儿科学分会神经学组生酮饮食疗法协作组. 长期生酮饮食治疗儿童难治性癫痫的前瞻性多中心研究. 中华儿科杂志, 2013, 51(4): 276-282.
6.	Gavatha M, Ioannou I, Papavasiliou AS. Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmaco resistant focal epilepsy. Epilepsy Behav, 2011, 20(6): 691-693.
7.	Heyman E, Lahat E, Levin N, et al. Preliminary efficacy and safety of lacosamide in children with refractory epilepsy. Eur J Paediatr Neurol, 2012, 16(1): 15-19.
8.	Yorns WR, Khurana DS, Carvalho KS, et al. Efficacy of lacosamide as adjunctive therapy in children with refractory epilepsy. J Child Neurol, 2014, 29(1): 23-27.
9.	Guilhoto LM, Loddenkemper T, Gooty VD, et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol, 2011, 44(3): 414-419.
10.	Rastogi RG, Ng Y. Lacosamide in refractory mixed pediatric epilepsy: a prospective add-on study. J Child Neurol, 2012, 27(4): 492-495.
11.	Miskin Chandrabhaga, Khurana Divya S, Valencia Ignacio, et al. Efficacy and tolerability of Lacosamide in the treatment of children with refractory generalized epilepsy. Journal of Child Neurology, 2016, 31(7): 925-928.
12.	Farkas V, Steinborn B, Flamini JR, et al. Efficacy and tolerability of adjunctive Lacosamide in children and adolescents with uncontrolled focal seizures: a randomized, double-blind, placebo-controlled trial. Poster presented at American Epilepsy Society Annual Meeting, 2017: 1-5, Washington, DC, USA.
13.	Wehnert, Bauers, Hamrh M, et al. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy Behav, 2009, 16(3): 423-425.
14.	Bialer, Johannesseni, Levyr, et al. Progress reporton new antiepileptic drugs: A summary of the ninth eilat conference (EILATIX). Epilepsy Res, 2009, 83(1): 1-43.
15.	Shaibania, Faress, Selam JL, et al. Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebocontrolled trial. J Pain, 2009, 10(8): 818-828.
16.	Zangaladze A, Skidmore C. Lacosamide use in refractory idiopathic primary generalized epilepsy. Epilepsy Behav, 2012, 23(1): 79-80.
17.	Biton V, Gil-Nagel A, Isojarvi J, et al. Safety and tolerability of lacosamide as adjunctive therapy for adults with partial-onset seizures: analysis of data pooled from three randomized, double-blind, placebo-controlled clinical trials. Epilepsy Behav, 2015, 52(2): 119-127.

1. Hirtz D, Thurman DJ, Gwinn-Hardy K, et al. How common are the common neurologic disorders? Neurology, 2007, 68(5): 326-337.
2. Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med, 1996, 334(3): 168-175.
3. Giráldez BG, Toledano R, García-morales I, et al. Long-term efficacy and safety of lacosamide monotherapy in the treatment of partial-onset seizures: A multicenter evaluation. Seizure, 2015, 29(1): 119-122.
4. Cawello W, Stockis A, Andreas JO, et al. Advances in epilepsy treatment: lacosamide pharmacokinetic profle. Ann NY Acad Sci, 2014, 1329(1): 18-32.
5. 中华医学会儿科学分会神经学组生酮饮食疗法协作组. 长期生酮饮食治疗儿童难治性癫痫的前瞻性多中心研究. 中华儿科杂志, 2013, 51(4): 276-282.
6. Gavatha M, Ioannou I, Papavasiliou AS. Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmaco resistant focal epilepsy. Epilepsy Behav, 2011, 20(6): 691-693.
7. Heyman E, Lahat E, Levin N, et al. Preliminary efficacy and safety of lacosamide in children with refractory epilepsy. Eur J Paediatr Neurol, 2012, 16(1): 15-19.
8. Yorns WR, Khurana DS, Carvalho KS, et al. Efficacy of lacosamide as adjunctive therapy in children with refractory epilepsy. J Child Neurol, 2014, 29(1): 23-27.
9. Guilhoto LM, Loddenkemper T, Gooty VD, et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol, 2011, 44(3): 414-419.
10. Rastogi RG, Ng Y. Lacosamide in refractory mixed pediatric epilepsy: a prospective add-on study. J Child Neurol, 2012, 27(4): 492-495.
11. Miskin Chandrabhaga, Khurana Divya S, Valencia Ignacio, et al. Efficacy and tolerability of Lacosamide in the treatment of children with refractory generalized epilepsy. Journal of Child Neurology, 2016, 31(7): 925-928.
12. Farkas V, Steinborn B, Flamini JR, et al. Efficacy and tolerability of adjunctive Lacosamide in children and adolescents with uncontrolled focal seizures: a randomized, double-blind, placebo-controlled trial. Poster presented at American Epilepsy Society Annual Meeting, 2017: 1-5, Washington, DC, USA.
13. Wehnert, Bauers, Hamrh M, et al. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy Behav, 2009, 16(3): 423-425.
14. Bialer, Johannesseni, Levyr, et al. Progress reporton new antiepileptic drugs: A summary of the ninth eilat conference (EILATIX). Epilepsy Res, 2009, 83(1): 1-43.
15. Shaibania, Faress, Selam JL, et al. Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebocontrolled trial. J Pain, 2009, 10(8): 818-828.
16. Zangaladze A, Skidmore C. Lacosamide use in refractory idiopathic primary generalized epilepsy. Epilepsy Behav, 2012, 23(1): 79-80.
17. Biton V, Gil-Nagel A, Isojarvi J, et al. Safety and tolerability of lacosamide as adjunctive therapy for adults with partial-onset seizures: analysis of data pooled from three randomized, double-blind, placebo-controlled clinical trials. Epilepsy Behav, 2015, 52(2): 119-127.

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