A study on the classification of paroxysmal diseases and epilepsy seizures in Tibet_Journal of Epilepsy

Authors：

HE Shihua ^1,2 , ZHUO Ma ² ,  ZHAO Yuhua ^1,2 , YAN Jing ^1,2

1. Department of Medicine, Tibet University, Lhasa 850000, China;
2. Department of Neurology, the People's Hospital of Tibet Autonomous Region (TAR), Lhasa 850000, China;

Corresponding author：

ZHAO Yuhua, Email: drolyang@163.com

Keywords：

Paroxysmal disease; Epilepsy; Altitude; Tibet

DOI：

10.7507/2096-0247.20200037

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the types and characteristics of common paroxysmal diseases in order to improve the diagnosis of onset types and to analyze the related factors of epileptic seizures in Tibetan population.Methods 510 patients with paroxysmal diseases were enrolled in the Department of Neurology, People's Hospital of Tibet Autonomous Region from June 2013 to December 2018 and the video electroencephalogram (VEEG) data were analyzed.Results Among the 510 patients, there were 35 types of paroxysmal diseases, 335 cases (65.69%) of seizures and 86 cases (16.86%) of psychogenic non-epileptic seizures (PNES). There were significant differences in the incidence of seizures between male and female patients (P<0.05), the incidence of seizures were different at different altitude and the concentration of hemoglobin (P<0.05), the course of seizures was always more than 2 years (P<0.05), and the frequency and age of seizures were higher, but there were no significant difference, and epileptic patients in Tibet were more likely to be young adults (34.51%).Conclusions There are many kinds of paroxysmal diseases in Tibetan population, and epileptic seizures are the main type. There was a qualitative relationship between the incidence of epilepsy and altitude. The incidence of epilepsy didn’t increase along with the increase of hemoglobin, and the course of seizures was mostly more than 2 years.

Citation： HE Shihua, ZHUO Ma, ZHAO Yuhua, YAN Jing. A study on the classification of paroxysmal diseases and epilepsy seizures in Tibet. Journal of Epilepsy, 2020, 6(3): 210-214. doi: 10.7507/2096-0247.20200037 Copy

1.	范杰, 徐海清, 闫福岭. 症状学研究在发作性疾病中的诊断价值. 医学综述, 2012, 18(22): 3800-3802.
2.	Stafstrom CE, Carmant L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harb Perspect Med, 2015, 5(6): a022426.
3.	Avbersek A, Sisodiya S. Does the primary literature provide support for clinical signs used to distinguish psychogenic nonepileptic seizures from epileptic seizures? J Neurol Neurosurg Psychiatry, 2010, 81(7): 719-725.
4.	Auxéméry Y, Hubsch C, Fidelle G. Psychogenic non epileptic seizures: a review. Encephale, 2011, 37(2): 153-158.
5.	武豫冬, 李志宏, 李琼仙. 视频脑电图监测发作性疾病 1430 例临床分析. 转化医学杂志, 2016, 5(1): 24-25+41.
6.	Pourkalbassi D, Patel P. Conversion Disorder: The Brain's Way of Dealing with Psychological Conflicts. Case Report of a Patient with Non-epileptic Seizures. Cureus, 2019, 11: e3902.
7.	刘晓燕主编. 临床脑电图学. 第 2 版. 北京: 人民卫生出版社, 2017: 92-93.
8.	Benbadis SR, O’Neill E, Tatum WO, et al. Outcome of prolonged video-EEG monitoring at a typical referral epilepsy center. Epilepsia, 2004, 45(9): 1150-1153.
9.	姚丹, 邓星强. 探究 24 小时动态脑电图在小儿癫痫诊断中的临床应用. 中国妇幼健康研究, 2015, 4(5): 966-967.
10.	孟红梅, 李娜, 崔俐, 等. 吉林省部分农村地区癫痫流行病学调查. 中风与神经疾病杂志, 2010, 27(12): 1108-1110.
11.	黄茂盛, 洪震, 曾军, 等. 上海市金山区农村癫癎流行病学调查研究. 临床神经电生理学杂志, 2001, (04): 196-198+205.
12.	Forsgren L, Beghi E, Oun A, et al. The epidemiology of epilepsy in Europe-a systematic review. Eur J Neurol, 2005, 12(4): 245-253.
13.	Theodore WH, Spencer SS, Wiebe S, et al. Epilepsy in North America: a report prepared under the auspices of the globalcampaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization. Epilepsia, 2006, 47(10): 1700-1722.
14.	张涛, 赵玉华, 郝渝, 等. 拉萨地区脑卒中 464 例分析. 中华神经科杂志, 2015, 48(10): 861-865.
15.	于振华, 董红, 毛德华, 等. 641 例脑囊虫病致癫痫临床分析. 中风与神经疾病杂志, 2003, (02): 75-77.
16.	黄华生, 韦仕荣, 潘鹏克, 等. 脑囊虫病 75 例临床分析. 广西医学, 2015, 37(11): 1671-1673+1676.
17.	次仁潘多. 西藏不同海拔高度世居藏族和移居人群高原适应不全的流行病学调查与分子机制研究. 西藏大学, 硕士学位论文, 2017.
18.	Frisancho AR. Developmental functional adaptation to high altitude: review. American Journalof human biology, 2013, 25(1): 151-168.
19.	Samantha L. Budda Mechanisms of neuronal damage in brain hypoxia/ischemia: focus on the role of mitochondrial calcium accumulation. Pharmacology & therapeutics, 1998, 80(2): 203-229.
20.	Busl KM. Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. Neuro Rehabilitation, 2010, 26(1): 5-13.
21.	Mehta SL, Kumari S, Mendelev N. Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia. BMC Neurosci, 2012, 13(1): 79.
22.	Bindokas VP, Lee CC, Colmers WF, et al. Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice. J Neurosci, 1998, 18(12): 4570-4587.
23.	Blomgren K. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free radical biology & medicine, 2006, 40(3): 388-397.

1. 范杰, 徐海清, 闫福岭. 症状学研究在发作性疾病中的诊断价值. 医学综述, 2012, 18(22): 3800-3802.
2. Stafstrom CE, Carmant L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harb Perspect Med, 2015, 5(6): a022426.
3. Avbersek A, Sisodiya S. Does the primary literature provide support for clinical signs used to distinguish psychogenic nonepileptic seizures from epileptic seizures? J Neurol Neurosurg Psychiatry, 2010, 81(7): 719-725.
4. Auxéméry Y, Hubsch C, Fidelle G. Psychogenic non epileptic seizures: a review. Encephale, 2011, 37(2): 153-158.
5. 武豫冬, 李志宏, 李琼仙. 视频脑电图监测发作性疾病 1430 例临床分析. 转化医学杂志, 2016, 5(1): 24-25+41.
6. Pourkalbassi D, Patel P. Conversion Disorder: The Brain's Way of Dealing with Psychological Conflicts. Case Report of a Patient with Non-epileptic Seizures. Cureus, 2019, 11: e3902.
7. 刘晓燕主编. 临床脑电图学. 第 2 版. 北京: 人民卫生出版社, 2017: 92-93.
8. Benbadis SR, O’Neill E, Tatum WO, et al. Outcome of prolonged video-EEG monitoring at a typical referral epilepsy center. Epilepsia, 2004, 45(9): 1150-1153.
9. 姚丹, 邓星强. 探究 24 小时动态脑电图在小儿癫痫诊断中的临床应用. 中国妇幼健康研究, 2015, 4(5): 966-967.
10. 孟红梅, 李娜, 崔俐, 等. 吉林省部分农村地区癫痫流行病学调查. 中风与神经疾病杂志, 2010, 27(12): 1108-1110.
11. 黄茂盛, 洪震, 曾军, 等. 上海市金山区农村癫癎流行病学调查研究. 临床神经电生理学杂志, 2001, (04): 196-198+205.
12. Forsgren L, Beghi E, Oun A, et al. The epidemiology of epilepsy in Europe-a systematic review. Eur J Neurol, 2005, 12(4): 245-253.
13. Theodore WH, Spencer SS, Wiebe S, et al. Epilepsy in North America: a report prepared under the auspices of the globalcampaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization. Epilepsia, 2006, 47(10): 1700-1722.
14. 张涛, 赵玉华, 郝渝, 等. 拉萨地区脑卒中 464 例分析. 中华神经科杂志, 2015, 48(10): 861-865.
15. 于振华, 董红, 毛德华, 等. 641 例脑囊虫病致癫痫临床分析. 中风与神经疾病杂志, 2003, (02): 75-77.
16. 黄华生, 韦仕荣, 潘鹏克, 等. 脑囊虫病 75 例临床分析. 广西医学, 2015, 37(11): 1671-1673+1676.
17. 次仁潘多. 西藏不同海拔高度世居藏族和移居人群高原适应不全的流行病学调查与分子机制研究. 西藏大学, 硕士学位论文, 2017.
18. Frisancho AR. Developmental functional adaptation to high altitude: review. American Journalof human biology, 2013, 25(1): 151-168.
19. Samantha L. Budda Mechanisms of neuronal damage in brain hypoxia/ischemia: focus on the role of mitochondrial calcium accumulation. Pharmacology & therapeutics, 1998, 80(2): 203-229.
20. Busl KM. Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. Neuro Rehabilitation, 2010, 26(1): 5-13.
21. Mehta SL, Kumari S, Mendelev N. Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia. BMC Neurosci, 2012, 13(1): 79.
22. Bindokas VP, Lee CC, Colmers WF, et al. Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice. J Neurosci, 1998, 18(12): 4570-4587.
23. Blomgren K. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free radical biology & medicine, 2006, 40(3): 388-397.

Previous Article
Surgical treatment for the cavernous angioma in the temporal lobe secondary to epilepsy
Next Article
靶向脑源性神经营养因子/酪氨酸激酶 B 信号通路对癫痫的抑制

Journal of Epilepsy

A study on the classification of paroxysmal diseases and epilepsy seizures in Tibet

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content