缺血性卒中后癫痫动物模型的研究进展_Journal of Epilepsy

Authors：

唐青青 ¹ ,  马勋泰 ^1,2

1. ;
2. ;

Corresponding author：

马勋泰, Email: maxuntai2002@126.com

Keywords：

缺血性卒中; 卒中后癫痫; 实验动物; 模型

DOI：

10.7507/2096-0247.20200070

Video：

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卒中后癫痫（Post-stroke epilepsy，PSE）是指继发于脑卒中的癫痫发作且既往无癫痫发作史，其病因包括出血性脑卒中和缺血性脑卒中。虽然缺血性 PSE 的发生率低于出血性脑卒中，但由于缺血性卒中患病率远高于出血性脑卒中，从而缺血性 PSE 患者也多于出血性 PSE 患者。作为脑卒中的常见并发症，卒中后早期癫痫发作会加重脑组织损伤，直接影响患者预后。为了研究缺血性 PSE 的发病机制，制定合理的治疗方案，构建了各种动物模型。文章就缺血性 PSE 动物模型研究进展进行综述。

Citation： 唐青青, 马勋泰. 缺血性卒中后癫痫动物模型的研究进展. Journal of Epilepsy, 2020, 6(5): 428-430. doi: 10.7507/2096-0247.20200070 Copy

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4.	司马林源, 李丹东, 张弩. 急性缺血性脑梗死动物模型研究进展. 医学研究杂志, 2018, 47(9): 190-193.
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8.	王林林, 雷瀛, 王子轩, 等. 近十年来线栓法制作MCAO大鼠模型的问题浅析. 牡丹江医学院学报, 2017, 38(4): 92-94.
9.	Zhang Z, Zhang RL, Jiang Q, <italic>et al</italic>. A new rat model of thrombotic focal cerebral ischemia. J Cereb Blood Flow Metab, 1997, 17(2): 123-135.
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14.	Morin L, Enderlin J, Leger PL, <italic>et al</italic>. Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. Neurobiol Dis, 2017, 99: 145-153.
15.	Bonnin P, Leger PL, Deroide N, <italic>et al</italic>. Impact of intracranial blood-flow redistribution on stroke size during ischemia-reperfusion in 7-day-old rats. J Neurosci Methods, 2011, 198(1): 103-109.
16.	Lei Z, Zhang H, Liang Y, <italic>et al</italic>. Reduced expression of IA channels is associated with post-ischemic seizures. Epilepsy Res, 2016, 124: 40-48.
17.	Xia L, Lei Z, Shi Z, <italic>et al</italic>. Enhanced autophagy signaling in diabetic rats with ischemia-induced seizures. Brain Res, 2016, 07(15): 18-26.
18.	宋祖耀, 王峰, 王文斐, 等. 高血糖对脑缺血卒中后癫痫发作的影响. 宁夏医科大学学报, 2015, 37(6): 635-637+729.
19.	Markowitz GJ, Kadam SD, Smith DR, <italic>et al</italic>. Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Res, 2011, 94(3): 138-148.
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21.	Wang J, Wu C, Peng J, <italic>et al</italic>. Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. PLoS One, 2015, 10(12): e0144113.
22.	管兴志, 匡培根. 光化学法诱导的脑梗死动物模型. 国外医学脑血管疾病分册, 2000, (05): 278-280.
23.	Kelly KM, Kharlamov A, Hentosz TM, <italic>et al</italic>. Photothrombotic brain infarction results in seizure activity in aging fischer 344 and sprague dawley rats. Epilepsy Res, 2001, 47(3): 189-203.
24.	Karhunen H, Bezvenyuk Z, Nissinen J, <italic>et al</italic>. Epileptogenesis after cortical photothrombotic brain lesion in rats. Neuroscience, 2007, 148(1): 314-324.

1. 黄远桂. 脑卒中与癫痫. 中华老年心脑血管病杂志, 2013, 15(5): 449-451.
2. Adelöw C, Andersson T, Ahlbom A, <italic>et al</italic>. Prior hospitalization for stroke, diabetes, myocardial infarction, and subsequent risk of unprovoked seizures. Epilepsia, 2011, 52(2): 301-307.
3. Fox CK, Glass HC, Sidney S, <italic>et al</italic>. Acute seizures predict epilepsy after childhood stroke. Ann Neurol, 2013, 74(2): 249-256.
4. 司马林源, 李丹东, 张弩. 急性缺血性脑梗死动物模型研究进展. 医学研究杂志, 2018, 47(9): 190-193.
5. Alkayed NJ, Harukuni I, Kimes AS, <italic>et al</italic>. Gender-linked brain injury in experimental stroke. Stroke, 1998, 29(1): 159-165.
6. Manwani B, Liu F, Xu Y, <italic>et al</italic>. Functional recovery in aging mice after experimental stroke. Brain Behav Immun, 2011, 25(8): 1689-1700.
7. Tsuji M, Ohshima M, Taguchi A, <italic>et al</italic>. A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model. Exp Neurol, 2013, 247: 218-225.
8. 王林林, 雷瀛, 王子轩, 等. 近十年来线栓法制作MCAO大鼠模型的问题浅析. 牡丹江医学院学报, 2017, 38(4): 92-94.
9. Zhang Z, Zhang RL, Jiang Q, <italic>et al</italic>. A new rat model of thrombotic focal cerebral ischemia. J Cereb Blood Flow Metab, 1997, 17(2): 123-135.
10. Atochin DN, Murciano JC, Gürsoy-Ö zdemir Y, <italic>et al</italic>. Mouse model of microembolic stroke and reperfusion. Stroke, 2004, 35(9): 2177-2182.
11. Karhunen H, Nissinen J, Sivenius J, <italic>et al</italic>. A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats. Epilepsy Res, 2006, 72(1): 25-38.
12. Kelly KM, Jukkola PI, Kharlamov EA, <italic>et al</italic>. Long-term video-EEG recordings following transient unilateral middle cerebral and common carotid artery occlusion in Long-Evans rats. Exp Neurol, 2006, 201(2): 495-506.
13. Karhunen H, Pitkänen A, Virtanen T, <italic>et al</italic>. Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits. Epilepsy Res, 2003, 54(1): 1-10.
14. Morin L, Enderlin J, Leger PL, <italic>et al</italic>. Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. Neurobiol Dis, 2017, 99: 145-153.
15. Bonnin P, Leger PL, Deroide N, <italic>et al</italic>. Impact of intracranial blood-flow redistribution on stroke size during ischemia-reperfusion in 7-day-old rats. J Neurosci Methods, 2011, 198(1): 103-109.
16. Lei Z, Zhang H, Liang Y, <italic>et al</italic>. Reduced expression of IA channels is associated with post-ischemic seizures. Epilepsy Res, 2016, 124: 40-48.
17. Xia L, Lei Z, Shi Z, <italic>et al</italic>. Enhanced autophagy signaling in diabetic rats with ischemia-induced seizures. Brain Res, 2016, 07(15): 18-26.
18. 宋祖耀, 王峰, 王文斐, 等. 高血糖对脑缺血卒中后癫痫发作的影响. 宁夏医科大学学报, 2015, 37(6): 635-637+729.
19. Markowitz GJ, Kadam SD, Smith DR, <italic>et al</italic>. Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Res, 2011, 94(3): 138-148.
20. Kadam SD, White AM, Staley KJ, <italic>et al</italic>. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. J Neurosci, 2010, 30(1): 404-415.
21. Wang J, Wu C, Peng J, <italic>et al</italic>. Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. PLoS One, 2015, 10(12): e0144113.
22. 管兴志, 匡培根. 光化学法诱导的脑梗死动物模型. 国外医学脑血管疾病分册, 2000, (05): 278-280.
23. Kelly KM, Kharlamov A, Hentosz TM, <italic>et al</italic>. Photothrombotic brain infarction results in seizure activity in aging fischer 344 and sprague dawley rats. Epilepsy Res, 2001, 47(3): 189-203.
24. Karhunen H, Bezvenyuk Z, Nissinen J, <italic>et al</italic>. Epileptogenesis after cortical photothrombotic brain lesion in rats. Neuroscience, 2007, 148(1): 314-324.

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