Analysis of 24 cases of intractable temporal lobe epilepsy surgery_Journal of Epilepsy

Authors：

ZHANG Haozheng ^1,2 , LI Kun ³ , YU Huafeng ⁴ , WANG Guangxin ⁵ , MENG Jiao ⁶ ,  CHEN Jie ¹

1. Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan 250012, China;
2. Pediatric Research Institute, Jinan Children's Hospital,Jinan, Shandong 250022, China;
3. Department of Neurology, Changguo Hospital, Zibo, Shandong 250022, China;
4. Pediatric Internal Medicine Department, Jinan Children's Hospital,Jinan, Shandong 250022, China;
5. Institute of Translational Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China;
6. Pathology Department, Jinan Children's Hospital,Jinan, Shandong 250022, China;

Corresponding author：

CHEN Jie, Email: 77chenjie@sdu.edu.cn

Keywords：

Intractable epilepsy; Hippocampal sclerosis; Surgery

DOI：

10.7507/2096-0247.20210005

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Objective To investigate the status and prognosis effect of surgical operation for Temporal lobe epilepsy.Methods Retrospective analyses were performed on 24 patients with intractable temporal lobe epilepsy who were treated by surgery in Zibo Changguo Hospital and had complete clinical and follow-up data, during the period from April 2011 to June 2014. Among them, 14 were male and 10 were female, 16 to 44 years old, the average age was (24.40±6.26) years old, and the average course of disease was (12.50±8.42) years old. The clinical characteristics and prognosis of the patients were analyzed.Results All 24 patients had hippocampal sclerosis and underwent "anterior temporal lobe and medial temporal structural resection". Patients were followed up for 5~7 years, the postoperative epileptic seizure of the patient reached grade Engel Ⅰ in 20 cases (83.3%), grade Engel Ⅱ in 2 cases (8.3%) and grade Engel Ⅳ in 2 cases (8.3%).Conclusion Hippocampal sclerosis and cortical dysplasia were common in 24 patients, and the operation controlling intractable epilepsy was better. In order to improve the prognosis of patients, surgical treatment should be carried out as soon as possible.

Citation： ZHANG Haozheng, LI Kun, YU Huafeng, WANG Guangxin, MENG Jiao, CHEN Jie. Analysis of 24 cases of intractable temporal lobe epilepsy surgery. Journal of Epilepsy, 2021, 7(1): 34-38. doi: 10.7507/2096-0247.20210005 Copy

1.	叶林妹, 陈聪, 丁芳, 等. 磁共振成像阴性颞叶癫痫的临床特点分析. 中华神经科杂志, 2020, 53(2): 103-109.
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5.	Guang-Xin Wang, Da-Wei Wang, Yong Liu, et al. Intractable epilepsy and the P-glycoprotein hypothesis. Int J Neurosci, 2016, 26(5): 385-392.
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7.	孔德燕, 罗杰峰, 石胜良, 等. 药物难治性癫痫患者认知功能损害影响因素的研究. 脑与神经疾病杂志, 2020, 28(4): 251-254.
8.	喻韬, 罗蓉, 周东, 等. 西南地区40例儿童癫痫手术病例分析. 四川大学学报(医学版), 2019, 50(2): 272-275.
9.	华刚, 谭红平, 姜楠, 等. 结节性硬化的诊断及相关药物难治性癫痫的手术治疗. 临床神经外科杂志, 2019, 16(4): 304-308, 314.
10.	范吉康, 尹绍雅. 迷走神经刺激治疗癫痫新进展. 中国实用神经疾病杂志, 2019, 22(8): 910-916.
11.	张祎鸣, 钱若兵, 傅先明, 等. 迷走神经刺激术治疗药物难治性癫痫的疗效分析(附110例报道). 中华神经外科杂志, 2019, 35(10): 1059-1063.
12.	Nitin Tandon, Brian A Tong, Elliott R Friedman, et al. Analysis of morbidity and outcomes associated with use of subdural grids vs stereoelectroencephalography in patients with intractable epilepsy. JAMA Neurol, 2019, 76(6): 672-681.
13.	Foit NA, Bernasconi A, Ladbon-Bernasconi N. Contributions of imaging to neuromodulatory treatment of drug-refractory epilepsy. Brain Sci, 2020, 10(10): 700.
14.	Philipp S Reif, Adam Strzelczyk, Felix Rosenow, et al. The history of invasive EEG evaluation in epilepsy patients. Seizure, 2016, 41(10): 191-195.
15.	Nitesh Shrestha. 磁共振成像在颞叶癫痫中的应用. 实用放射学杂志, 2020, 36(5): 838-841.
16.	Azab SF, Sherief LM, Saleh SH, et al. Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study. Ital J Pediatr, 2015, 41(1): 32.

1. 叶林妹, 陈聪, 丁芳, 等. 磁共振成像阴性颞叶癫痫的临床特点分析. 中华神经科杂志, 2020, 53(2): 103-109.
2. CY Lee, T Wu, CW Chang, et al. Electrical cortical stimulation for treatment of intractable epilepsy originating from eloquent cortex: surgical accuracy and clinical efficacy. Acta Neurochir (Wien), 2020, 162(2): 261-269.
3. 霍俊杰. 难治性颞叶癫痫的手术预后及相关影响因素分析. 南京医科大学, 2019, 硕士学位论文: 4-17.
4. K Kamada, C Kapeller, F Takeuchi, et al. Tailor-made surgery based on functional networks for intractable epilepsy. Front Neurol, 2020, 11(1): 73.
5. Guang-Xin Wang, Da-Wei Wang, Yong Liu, et al. Intractable epilepsy and the P-glycoprotein hypothesis. Int J Neurosci, 2016, 26(5): 385-392.
6. Taoyun Ji, Zhao Yang, Qingzhu Liu, et al. Vagus nerve stimulation for pediatric patients with intractable epilepsy between 3 and 6 years of age: study protocol for a double-blind, randomized control trial. Trials, 2019, 20(1): 44.
7. 孔德燕, 罗杰峰, 石胜良, 等. 药物难治性癫痫患者认知功能损害影响因素的研究. 脑与神经疾病杂志, 2020, 28(4): 251-254.
8. 喻韬, 罗蓉, 周东, 等. 西南地区40例儿童癫痫手术病例分析. 四川大学学报(医学版), 2019, 50(2): 272-275.
9. 华刚, 谭红平, 姜楠, 等. 结节性硬化的诊断及相关药物难治性癫痫的手术治疗. 临床神经外科杂志, 2019, 16(4): 304-308, 314.
10. 范吉康, 尹绍雅. 迷走神经刺激治疗癫痫新进展. 中国实用神经疾病杂志, 2019, 22(8): 910-916.
11. 张祎鸣, 钱若兵, 傅先明, 等. 迷走神经刺激术治疗药物难治性癫痫的疗效分析(附110例报道). 中华神经外科杂志, 2019, 35(10): 1059-1063.
12. Nitin Tandon, Brian A Tong, Elliott R Friedman, et al. Analysis of morbidity and outcomes associated with use of subdural grids vs stereoelectroencephalography in patients with intractable epilepsy. JAMA Neurol, 2019, 76(6): 672-681.
13. Foit NA, Bernasconi A, Ladbon-Bernasconi N. Contributions of imaging to neuromodulatory treatment of drug-refractory epilepsy. Brain Sci, 2020, 10(10): 700.
14. Philipp S Reif, Adam Strzelczyk, Felix Rosenow, et al. The history of invasive EEG evaluation in epilepsy patients. Seizure, 2016, 41(10): 191-195.
15. Nitesh Shrestha. 磁共振成像在颞叶癫痫中的应用. 实用放射学杂志, 2020, 36(5): 838-841.
16. Azab SF, Sherief LM, Saleh SH, et al. Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study. Ital J Pediatr, 2015, 41(1): 32.

Journal of Epilepsy

Analysis of 24 cases of intractable temporal lobe epilepsy surgery

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