癫痫相关睡眠时相异常及认知障碍发病机制的研究进展_Journal of Epilepsy

Authors：

于凯 ¹ , 卜凡 ¹ , 邵欣东 ¹ , 孙雪 ¹ , 郝雷 ¹ , 夏蕾 ¹ ,  李鹏 ²

1. ;
2. ;

Corresponding author：

李鹏, Email: hlp8079@163.com

Keywords：

睡眠异常; 癫痫; 发病机制; 认知障碍; 综述

DOI：

10.7507/2096-0247.20210009

Video：

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癫痫是由脑内局部神经元兴奋性过高而产生的阵发性异常高频放电的病症，其发病机制复杂多样，可能因离子通道、神经胶质细胞、神经递质等异常而导致。近年来，越来越多的学者关注到睡眠对于癫痫患者疾病进程的影响，且睡眠异常的癫痫患者常伴有认知功能障碍，对患者的生活质量造成不良影响。文章对近年来睡眠引起癫痫的发病机制和睡眠对于癫痫患者认知功能影响的研究进展作一综述。

Citation： 于凯, 卜凡, 邵欣东, 孙雪, 郝雷, 夏蕾, 李鹏. 癫痫相关睡眠时相异常及认知障碍发病机制的研究进展. Journal of Epilepsy, 2021, 7(1): 54-57. doi: 10.7507/2096-0247.20210009 Copy

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2.	Musto E, Gardella E, Møller RS. Recent advances in treatment of epilepsy-related sodium channelopathies. Eur J Paediatr Neurol, 2020, 24: 123-128.
3.	Han S, Yu FH, Schwartz MD, et al. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A, 2012, 109(6): E368-E377.
4.	张慧敏, 田欢, 张晶钰. 钠离子通道在神经性疾病发病机制的研究进展. 基因组学与应用生物学, 2020, 38(1): 1-13.
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6.	Wei F, Yan LM, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
7.	Deng Chen, Yang Si, Jun He, et al. Terminal seizure frequency and its relation to SUDEP. Epilepsy Behav, 2017, 70(Pt A): 173-176.
8.	Köhling R, Wolfart J. Potassium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(5): a022871.
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10.	Cheong E, Shin HS. T-type Ca²⁺ channels in normal and abnormal brain functions. Physiol Rev, 2013, 93(3): 961-992.
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12.	Murillo-Rodriguez E, Arias-Carrion O, Zavala-Garcia A, et al. Basic sleep mechanisms: an integrative review. Cent Nerv Syst Agents Med Chem, 2012, 12(1): 38-54.
13.	Brown RE, Basheer R, McKenna JT, et al. Control of sleep and wakefulness. Physiol Rev, 2012, 92(3): 1087-1187.
14.	Verkhratsky A, Ho MS, Zorec R, et al. The concept of neuroglia. Adv Exp Med Biol, 2019, 1175: 1-13.
15.	Filous AR, Silver J. Targeting astrocytes in CNS injury and disease: A translational research approach. Prog Neurobiol, 2016, 144: 173-187.
16.	Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab, 2012, 32(7): 1152-1166.
17.	陈忠, 孙红柳. 星形胶质细胞在癫痫发病中的作用. 浙江大学学报(医学版), 2013, 42(3): 245-252.
18.	Lazarus M, Chen JF, Huang ZL, et al. Adenosine and sleep. Handb Exp Pharmacol, 2019, 253: 359-381.
19.	Boison D, Steinhäuser C. Epilepsy and astrocyte energy metabolism. Glia, 2018, 66(6): 1235-1243.
20.	Eid T, Gruenbaum SE., Dhaher R., et al The glutamate–glutamine cycle in epilepsy. Adv Neurobiol, 2016, 13: 351-400.
21.	彭毓棻, 宋治. NMDA受体在癫痫发病机制中的作用. 中国病理生理杂志, 2011, 27(06): 1230-1233+1239.
22.	于欢, 洪震. 癫痫患者的认知功能障碍. 中国临床康复, 2004, 10(22): 4586-4588.
23.	Zhu S, Noviello CM, Teng J, et al. Structure of a human synaptic GABAA receptor. Nature, 2018, 559(7712): 67-72.
24.	Helmstaedter C, Witt JA. Epilepsy and cognition – A bidirectional relationship? Seizure, 2017, 49: 83-89.
25.	Janati AB, ALGhasab NS, Aldaife MY, et al. A typical interictal epileptiform discharges in electroencephalography. J Epilepsy Res, 2018, 8(2): 55-60.
26.	Braun KPJ. Preventing cognitive impairment in children with epilepsy. Current Opinion in Neurology, 2017, 30(2): 140-147.
27.	Liu XY., Shi T, Yin WN, et al Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128: 1-5.
28.	Gelinas JN, Khodagholy D, Thesen T, et al. Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med, 2016, 22(6): 641-648.
29.	Horak PC, Meisenhelter S, Song Y, et al. Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia, 2017, 58(3): 373-380.
30.	Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathology and Applied Neurobiology, 2018, 44(1): 112-129.
31.	Eastman CL, D'Ambrosio R, Ganesh T. Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury. Neuropharmacology, 2020, 172: 107907.
32.	陈美丽, 白宇. 癫痫与认知功能关系的研究进展. 中国康复理论与实践, 2012, 18(4): 341-343.
33.	Löscher W, Friedman A. Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: A cause, consequence, or both? Int J Mol Sci, 2020, 21(2): 591.
34.	Prager O, Kamintsky L, Hasam-Henderson LA, et al. Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction. Epilepsia, 2019, 60(2): 322-336.
35.	Wang L, Chen S, Liu C, et al. Factors for cognitive impairment in adult epileptic patients. Brain Behav, 2020, 10(1): e01475.
36.	Kataria, L., & Vaughn, B. V Sleep and epilepsy. Sleep Medicine Clinics, 2016, 11(1): 25-38.
37.	Bazil, C. Sleep and epilepsy. Seminars in Neurology, 2017, 37(04): 407-412.
38.	Wennberg AMV, Wu MN, Rosenberg PB, et al. Sleep disturbance, cognitive decline, and dementia: a review. Semin Neurol, 2017, 37(4): 395-406.
39.	Lanigar S, Bandyopadhyay S. Sleep and epilepsy: a complex interplay. Mo Med, 2017, 114(6): 453-457.

1. Yuen AWC, Keezer MR, Sander JW. Epilepsy is a neurological and a systemic disorder. Epilepsy Behav, 2018, 78: 57-61.
2. Musto E, Gardella E, Møller RS. Recent advances in treatment of epilepsy-related sodium channelopathies. Eur J Paediatr Neurol, 2020, 24: 123-128.
3. Han S, Yu FH, Schwartz MD, et al. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A, 2012, 109(6): E368-E377.
4. 张慧敏, 田欢, 张晶钰. 钠离子通道在神经性疾病发病机制的研究进展. 基因组学与应用生物学, 2020, 38(1): 1-13.
5. Wallace E, Wright S, Schoenike B, et al. Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy. Epilepsia, 2018, 59(8): 1527-1539.
6. Wei F, Yan LM, Su T, et al. Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci Bull, 2017, 33(4): 455-477.
7. Deng Chen, Yang Si, Jun He, et al. Terminal seizure frequency and its relation to SUDEP. Epilepsy Behav, 2017, 70(Pt A): 173-176.
8. Köhling R, Wolfart J. Potassium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(5): a022871.
9. Rajakulendran S, Hanna MG. The role of calcium channels in epilepsy. Cold Spring Harb Perspect Med, 2016, 6(1): a022723.
10. Cheong E, Shin HS. T-type Ca²⁺ channels in normal and abnormal brain functions. Physiol Rev, 2013, 93(3): 961-992.
11. Tillman L, Zhang J. Crossing the chloride channel: the current and potential therapeutic value of the neuronal K⁺-Cl^- Cotransporter KCC2. Biomed Res Int, 2019, 25(12): 8941046.
12. Murillo-Rodriguez E, Arias-Carrion O, Zavala-Garcia A, et al. Basic sleep mechanisms: an integrative review. Cent Nerv Syst Agents Med Chem, 2012, 12(1): 38-54.
13. Brown RE, Basheer R, McKenna JT, et al. Control of sleep and wakefulness. Physiol Rev, 2012, 92(3): 1087-1187.
14. Verkhratsky A, Ho MS, Zorec R, et al. The concept of neuroglia. Adv Exp Med Biol, 2019, 1175: 1-13.
15. Filous AR, Silver J. Targeting astrocytes in CNS injury and disease: A translational research approach. Prog Neurobiol, 2016, 144: 173-187.
16. Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab, 2012, 32(7): 1152-1166.
17. 陈忠, 孙红柳. 星形胶质细胞在癫痫发病中的作用. 浙江大学学报(医学版), 2013, 42(3): 245-252.
18. Lazarus M, Chen JF, Huang ZL, et al. Adenosine and sleep. Handb Exp Pharmacol, 2019, 253: 359-381.
19. Boison D, Steinhäuser C. Epilepsy and astrocyte energy metabolism. Glia, 2018, 66(6): 1235-1243.
20. Eid T, Gruenbaum SE., Dhaher R., et al The glutamate–glutamine cycle in epilepsy. Adv Neurobiol, 2016, 13: 351-400.
21. 彭毓棻, 宋治. NMDA受体在癫痫发病机制中的作用. 中国病理生理杂志, 2011, 27(06): 1230-1233+1239.
22. 于欢, 洪震. 癫痫患者的认知功能障碍. 中国临床康复, 2004, 10(22): 4586-4588.
23. Zhu S, Noviello CM, Teng J, et al. Structure of a human synaptic GABAA receptor. Nature, 2018, 559(7712): 67-72.
24. Helmstaedter C, Witt JA. Epilepsy and cognition – A bidirectional relationship? Seizure, 2017, 49: 83-89.
25. Janati AB, ALGhasab NS, Aldaife MY, et al. A typical interictal epileptiform discharges in electroencephalography. J Epilepsy Res, 2018, 8(2): 55-60.
26. Braun KPJ. Preventing cognitive impairment in children with epilepsy. Current Opinion in Neurology, 2017, 30(2): 140-147.
27. Liu XY., Shi T, Yin WN, et al Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128: 1-5.
28. Gelinas JN, Khodagholy D, Thesen T, et al. Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med, 2016, 22(6): 641-648.
29. Horak PC, Meisenhelter S, Song Y, et al. Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia, 2017, 58(3): 373-380.
30. Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathology and Applied Neurobiology, 2018, 44(1): 112-129.
31. Eastman CL, D'Ambrosio R, Ganesh T. Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury. Neuropharmacology, 2020, 172: 107907.
32. 陈美丽, 白宇. 癫痫与认知功能关系的研究进展. 中国康复理论与实践, 2012, 18(4): 341-343.
33. Löscher W, Friedman A. Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: A cause, consequence, or both? Int J Mol Sci, 2020, 21(2): 591.
34. Prager O, Kamintsky L, Hasam-Henderson LA, et al. Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction. Epilepsia, 2019, 60(2): 322-336.
35. Wang L, Chen S, Liu C, et al. Factors for cognitive impairment in adult epileptic patients. Brain Behav, 2020, 10(1): e01475.
36. Kataria, L., & Vaughn, B. V Sleep and epilepsy. Sleep Medicine Clinics, 2016, 11(1): 25-38.
37. Bazil, C. Sleep and epilepsy. Seminars in Neurology, 2017, 37(04): 407-412.
38. Wennberg AMV, Wu MN, Rosenberg PB, et al. Sleep disturbance, cognitive decline, and dementia: a review. Semin Neurol, 2017, 37(4): 395-406.
39. Lanigar S, Bandyopadhyay S. Sleep and epilepsy: a complex interplay. Mo Med, 2017, 114(6): 453-457.

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