基于连接性构筑图谱的岛叶-岛盖癫痫发作症状学亚组_Journal of Epilepsy

Authors：

WangHaixiang , McGonigalAileen , ZhangKai , 王海祥 , 吴逊　周文静　审

Corresponding author：

WangHaixiang, Email: ; McGonigalAileen, Email:

Keywords：

脑网络组图谱; 聚类分析; 岛叶发作; 症状学; 立体定向脑电图

DOI：

10.7507/2096-0247.20210011

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

岛叶-岛盖癫痫发作的特点是多样性的症状学表现，这与岛叶参与多种功能和广泛的连接有关。文章旨在确定其症状学亚组，并将它们与基于连接性构筑进行分区的岛叶-岛盖亚区相联系。回顾性收集来自 3 个癫痫中心 37 例立体定向脑电图（SEEG）检查确定的岛叶-岛盖癫痫发作的一组大样本量患者资料。基于解剖和功能连接的新的脑网络组图谱（Brainnetome atlas，BNA）被用于分割岛叶-岛盖皮质。仔细阅览症状学和 SEEG 的变化并进行量化，用主成分分析和聚类分析将症状学特征与岛叶-岛盖亚区相关联。基于 BNA 沿前腹侧-后背侧轴确定了 4 个主要的症状学亚组：第 1 组特征是上腹感觉和或协调性姿势性运动行为，伴有或不伴有恐惧或愤怒，涉及前腹侧岛叶和颞叶内侧结构；第 2 组特征是听觉及对称性近端肌或轴肌强直，涉及后腹侧的颞盖；第 3 组特征是口面部和喉部症状，涉及岛叶-岛盖的中间区；第 4 组特征是躯体感觉，继之出现非协调性姿势性运动行为和双侧非对称性强直，涉及后背侧岛叶-岛盖并传播至额叶内侧面。前腹部的癫痫发作主要表现为边缘系统症状学，而更靠后背侧的症状学主要涉及感觉运动系统。主观症状具有特殊的组别区分意义。可根据临床症状学对岛叶-岛盖癫痫发作进行分类，并将其与连接性构筑亚区相关联，它们沿前腹侧-后背侧轴排列，这与细胞构筑的梯度而非岛叶的沟回解剖相一致。这为岛叶-岛盖癫痫的鉴别诊断和术前定位提供了新思路，同时也强调了在确定复杂症状学模式的神经相关性时考虑连接性构筑的重要性。

Citation： WangHaixiang, McGonigalAileen, ZhangKai, 王海祥, 吴逊　周文静　审. 基于连接性构筑图谱的岛叶-岛盖癫痫发作症状学亚组. Journal of Epilepsy, 2021, 7(1): 62-70. doi: 10.7507/2096-0247.20210011 Copy

1.	Afif A, Chabardes S, Minotti L, et al. Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery, 2008, 62(2): ONS 471-479; discussion 479-480.
2.	Isnard J, Hagiwara K, Montavont A, et al. Semiology of insular lobe seizures. Rev Neurol (Paris), 2019, 175(1): 144-149.
3.	Obaid S, Zerouali Y, Nguyen DK. Insular epilepsy: Semiology and noninvasive investigations. J Clin Neurophysiol, 2017, 34(2): 315-323.
4.	Isnard J, Guenot M, Ostrowsky K, et al. The role of the insular cortex in temporal lobe epilepsy. Ann Neurol, 2000, 48(3): 614-623.
5.	Isnard J, Guenot M, Sindou M, et al. Clinical manifestations of insular lobe seizures: : A stereo‐electroencephalographic study. Epilepsia, 2004, 45(6): 1079-1090.
6.	Peltola ME, Trebuchon A, Lagarde S, et al. Anatomoelectroclinical features of SEEG-confirmed pure insular-onset epilepsy. Epilepsy Behav, 2020, 105: 106964.
7.	Cerliani L, Thomas RM, Jbabdi S, et al. Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex. Hum Brain Mapp, 2012, 33(10): 2005-2034.
8.	Jobst BC, Gonzalez-Martinez J, Isnard J, et al. The insula and its epilepsies. Epilepsy Curr, 2019, 19(1): 11-21.
9.	Nguyen DK, Nguyen DB, Malak R, et al. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia, 2009, 50(3): 510-520.
10.	Barba C, Minotti L, Job AS, et al. The insula in temporal plus epilepsy. J Clin Neurophysiol, 2017, 34(2): 324-327.
11.	Wang X, Hu W, McGonigal A, et al. Electroclinical features of insulo-opercular epilepsy: an SEEG and PET study. Ann Clin Transl Neurol, 2019, 6(10): 1165-1177.
12.	Proserpio P, Cossu M, Francione S, et al. Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: a stereo-EEG study. Epilepsia, 2011, 52(12): 1781-1791.
13.	Mullatti N, Landre E, Mellerio C, et al. Stereotactic thermocoagulation for insular epilepsy: Lessons from successes and failures. Epilepsia, 2019, 60(12): 1565-1579.
14.	Freri E, Matricardi S, Gozzo F, et al. Perisylvian, including insular, childhood epilepsy: Presurgical workup and surgical outcome. Epilepsia, 2017, 58(11): 1360-1369.
15.	Ostrowsky K, Magnin M, Ryvlin P, et al. Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex, 2002, 12(2): 376-385.
16.	Mazzola L, Mauguiere F, Isnard J. Electrical stimulations of the human insula: Their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol, 2017, 34(2): 307-314.
17.	Morel A, Gallay MN, Baechler A, et al. The human insula: Architectonic organization and postmortem MRI registration. Neuroscience, 2013, 236(1): 117-135.
18.	Ghaziri J, Tucholka A, Girard G, et al. The corticocortical structural connectivity of the human insula. Cereb Cortex, 2017, 27(10): 1216-1228.
19.	Cauda F, D'Agata F, Sacco K, et al. Functional connectivity of the insula in the resting brain. Neuroimage, 2011, 55(1): 8-23.
20.	Kurth F, Zilles K, Fox PT, et al. A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Structure & Function, 2010, 214(3): 519-534.
21.	Fan L, Li H, Zhuo J, et al. The human brainnetome atlas: A new brain atlas based on connectional architecture. Cereb Cortex, 2016, 26(12): 3508-3526.
22.	Kelly C, Toro R, Di Martino A, et al. A convergent functional architecture of the insula emerges across imaging modalities. Neuroimage, 2012, 61(7): 1129-1142.
23.	Bartolomei F, Chauvel P, Wendling F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG. Brain, 2008, 131(12): 1818-1830.
24.	Wang H, David O, Zhou W, et al. Distinctive epileptogenic networks for parietal operculum seizures. Epilepsy Behav, 2019, 91: 59-67.
25.	Qin C, Tan Z, Pan Y, et al. Automatic and precise localization and cortical labeling of subdural and depth intracranial electrodes. Front Neuroinform, 2017, 11(1): 10.
26.	Bonini F, McGonigal A, Trebuchon A, et al. Frontal lobe seizures: from clinical semiology to localization. Epilepsia, 2014, 55(1): 264-277.
27.	Maliia MD, Donos C, Barborica A, et al. Functional mapping and effective connectivity of the human operculum. Cortex, 2018, 109(2): 303-321.
28.	Wieser HG, Blume WT, Fish D, et al. ILAE Commission report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia, 2001, 42(2): 282-286.
29.	Dylgjeri S, Taussig D, Chipaux M, et al. Insular and insulo-opercular epilepsy in childhood: an SEEG study. Seizure, 2014, 23(2): 300-308.
30.	Mulak A, Kahane P, Hoffmann D, et al. Brain mapping of digestive sensations elicited by cortical electrical stimulations. Neurogastroenterol Motil, 2008, 20(3): 588-596.
31.	Eickhoff SB, Jbabdi S, Caspers S, et al. Anatomical and functional connectivity of cytoarchitectonic areas within the human parietal operculum. J Neurosci, 2010, 30: 6409-6421.
32.	Vaugier L, Aubert S, McGonigal A, et al. Neural networks underlying hyperkinetic seizures of "temporal lobe" origin. Epilepsy Res, 2009, 86(2): 200-208.
33.	Gibbs SA, Proserpio P, Francione S, et al. Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases. Epilepsia, 2019, 60(3): 707-717.
34.	Hagiwara K, Jung J, Bouet R, et al. How can we explain the frontal presentation of insular lobe epilepsy? The impact of non-linear analysis of insular seizures. Clin Neurophysiol. 2017;128(4): 780-791.
35.	Mesulam MM, Mufson EJ. Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain. J Comp Neurol, 1982, 212(1): 1-22.
36.	Arslan S, Ktena SI, Makropoulos A, et al. Human brain mapping: A systematic comparison of parcellation methods for the human cerebral cortex. Neuroimage, 2018, 170(1): 5-30.
37.	Mazzola L, Mauguiere F, Isnard J. Functional mapping of the human insula: Data from electrical stimulations. Rev Neurol (Paris), 2019, 175(2): 150-156.
38.	Bartolomei F, Lagarde S, Wendling F, et al. Defining epileptogenic networks: Contribution of SEEG and signal analysis. Epilepsia. 2017;58(6): 1131-1147.
39.	Kramer MA, Cash SS. Epilepsy as a disorder of cortical network organization. Neuroscientist, 2012, 18: 360-372.
40.	Richardson MP. Large scale brain models of epilepsy: dynamics meets connectomics. J Neurol Neurosurg Psychiatry, 2012, 83(6): 1238-1248.
41.	Chauvel P, McGonigal A. Emergence of semiology in epileptic seizures. Epilepsy Behav, 2014, 38: 94-103.
42.	Aupy J, Noviawaty I, Krishnan B, et al. Insulo-opercular cortex generates oroalimentary automatisms in temporal seizures. Epilepsia, 2018, 59(3): 583-594.
43.	McGonigal A. Semiology and epilepsy networks. Neurosurg Clin N Am. 2020, In press.

1. Afif A, Chabardes S, Minotti L, et al. Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery, 2008, 62(2): ONS 471-479; discussion 479-480.
2. Isnard J, Hagiwara K, Montavont A, et al. Semiology of insular lobe seizures. Rev Neurol (Paris), 2019, 175(1): 144-149.
3. Obaid S, Zerouali Y, Nguyen DK. Insular epilepsy: Semiology and noninvasive investigations. J Clin Neurophysiol, 2017, 34(2): 315-323.
4. Isnard J, Guenot M, Ostrowsky K, et al. The role of the insular cortex in temporal lobe epilepsy. Ann Neurol, 2000, 48(3): 614-623.
5. Isnard J, Guenot M, Sindou M, et al. Clinical manifestations of insular lobe seizures: : A stereo‐electroencephalographic study. Epilepsia, 2004, 45(6): 1079-1090.
6. Peltola ME, Trebuchon A, Lagarde S, et al. Anatomoelectroclinical features of SEEG-confirmed pure insular-onset epilepsy. Epilepsy Behav, 2020, 105: 106964.
7. Cerliani L, Thomas RM, Jbabdi S, et al. Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex. Hum Brain Mapp, 2012, 33(10): 2005-2034.
8. Jobst BC, Gonzalez-Martinez J, Isnard J, et al. The insula and its epilepsies. Epilepsy Curr, 2019, 19(1): 11-21.
9. Nguyen DK, Nguyen DB, Malak R, et al. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia, 2009, 50(3): 510-520.
10. Barba C, Minotti L, Job AS, et al. The insula in temporal plus epilepsy. J Clin Neurophysiol, 2017, 34(2): 324-327.
11. Wang X, Hu W, McGonigal A, et al. Electroclinical features of insulo-opercular epilepsy: an SEEG and PET study. Ann Clin Transl Neurol, 2019, 6(10): 1165-1177.
12. Proserpio P, Cossu M, Francione S, et al. Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: a stereo-EEG study. Epilepsia, 2011, 52(12): 1781-1791.
13. Mullatti N, Landre E, Mellerio C, et al. Stereotactic thermocoagulation for insular epilepsy: Lessons from successes and failures. Epilepsia, 2019, 60(12): 1565-1579.
14. Freri E, Matricardi S, Gozzo F, et al. Perisylvian, including insular, childhood epilepsy: Presurgical workup and surgical outcome. Epilepsia, 2017, 58(11): 1360-1369.
15. Ostrowsky K, Magnin M, Ryvlin P, et al. Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex, 2002, 12(2): 376-385.
16. Mazzola L, Mauguiere F, Isnard J. Electrical stimulations of the human insula: Their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol, 2017, 34(2): 307-314.
17. Morel A, Gallay MN, Baechler A, et al. The human insula: Architectonic organization and postmortem MRI registration. Neuroscience, 2013, 236(1): 117-135.
18. Ghaziri J, Tucholka A, Girard G, et al. The corticocortical structural connectivity of the human insula. Cereb Cortex, 2017, 27(10): 1216-1228.
19. Cauda F, D'Agata F, Sacco K, et al. Functional connectivity of the insula in the resting brain. Neuroimage, 2011, 55(1): 8-23.
20. Kurth F, Zilles K, Fox PT, et al. A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Structure & Function, 2010, 214(3): 519-534.
21. Fan L, Li H, Zhuo J, et al. The human brainnetome atlas: A new brain atlas based on connectional architecture. Cereb Cortex, 2016, 26(12): 3508-3526.
22. Kelly C, Toro R, Di Martino A, et al. A convergent functional architecture of the insula emerges across imaging modalities. Neuroimage, 2012, 61(7): 1129-1142.
23. Bartolomei F, Chauvel P, Wendling F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG. Brain, 2008, 131(12): 1818-1830.
24. Wang H, David O, Zhou W, et al. Distinctive epileptogenic networks for parietal operculum seizures. Epilepsy Behav, 2019, 91: 59-67.
25. Qin C, Tan Z, Pan Y, et al. Automatic and precise localization and cortical labeling of subdural and depth intracranial electrodes. Front Neuroinform, 2017, 11(1): 10.
26. Bonini F, McGonigal A, Trebuchon A, et al. Frontal lobe seizures: from clinical semiology to localization. Epilepsia, 2014, 55(1): 264-277.
27. Maliia MD, Donos C, Barborica A, et al. Functional mapping and effective connectivity of the human operculum. Cortex, 2018, 109(2): 303-321.
28. Wieser HG, Blume WT, Fish D, et al. ILAE Commission report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia, 2001, 42(2): 282-286.
29. Dylgjeri S, Taussig D, Chipaux M, et al. Insular and insulo-opercular epilepsy in childhood: an SEEG study. Seizure, 2014, 23(2): 300-308.
30. Mulak A, Kahane P, Hoffmann D, et al. Brain mapping of digestive sensations elicited by cortical electrical stimulations. Neurogastroenterol Motil, 2008, 20(3): 588-596.
31. Eickhoff SB, Jbabdi S, Caspers S, et al. Anatomical and functional connectivity of cytoarchitectonic areas within the human parietal operculum. J Neurosci, 2010, 30: 6409-6421.
32. Vaugier L, Aubert S, McGonigal A, et al. Neural networks underlying hyperkinetic seizures of "temporal lobe" origin. Epilepsy Res, 2009, 86(2): 200-208.
33. Gibbs SA, Proserpio P, Francione S, et al. Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases. Epilepsia, 2019, 60(3): 707-717.
34. Hagiwara K, Jung J, Bouet R, et al. How can we explain the frontal presentation of insular lobe epilepsy? The impact of non-linear analysis of insular seizures. Clin Neurophysiol. 2017;128(4): 780-791.
35. Mesulam MM, Mufson EJ. Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain. J Comp Neurol, 1982, 212(1): 1-22.
36. Arslan S, Ktena SI, Makropoulos A, et al. Human brain mapping: A systematic comparison of parcellation methods for the human cerebral cortex. Neuroimage, 2018, 170(1): 5-30.
37. Mazzola L, Mauguiere F, Isnard J. Functional mapping of the human insula: Data from electrical stimulations. Rev Neurol (Paris), 2019, 175(2): 150-156.
38. Bartolomei F, Lagarde S, Wendling F, et al. Defining epileptogenic networks: Contribution of SEEG and signal analysis. Epilepsia. 2017;58(6): 1131-1147.
39. Kramer MA, Cash SS. Epilepsy as a disorder of cortical network organization. Neuroscientist, 2012, 18: 360-372.
40. Richardson MP. Large scale brain models of epilepsy: dynamics meets connectomics. J Neurol Neurosurg Psychiatry, 2012, 83(6): 1238-1248.
41. Chauvel P, McGonigal A. Emergence of semiology in epileptic seizures. Epilepsy Behav, 2014, 38: 94-103.
42. Aupy J, Noviawaty I, Krishnan B, et al. Insulo-opercular cortex generates oroalimentary automatisms in temporal seizures. Epilepsia, 2018, 59(3): 583-594.
43. McGonigal A. Semiology and epilepsy networks. Neurosurg Clin N Am. 2020, In press.

Previous Article
第三代新型抗癫痫药吡仑帕奈在癫痫治疗中的研究进展
Next Article
有癫痫发作史患者的幻觉发生率与精神病理学意义

Journal of Epilepsy

基于连接性构筑图谱的岛叶-岛盖癫痫发作症状学亚组

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content