A preliminary investigation of adenoid hypertrophy in children with epilepsy_Journal of Epilepsy

Authors：

JIANG Yumei ¹ , LING Zhijuan ¹ , SU Ying ¹ , YE Jinghua ² , PAN Hongguang ¹ , LI Lan ¹ , YE Yuanzhen ² , HU Zhanqi ² , CAO Dezhi ² ,  LIAO Jianxiang ²

1. Department of Otolaryngology, Shenzhen Children’s Hospital, Shenzhen 518038, China;
2. Epilepsy Center, Shenzhen Children’s Hospital, Shenzhen 518038, China;

Corresponding author：

LIAO Jianxiang, Email: liaojianxiang@vip.sina.com

Keywords：

Epilepsy; Comorbidity; Adenoid hypertrophy; Clinical characteristics; Etiology; Nursing; Children

DOI：

10.7507/2096-0247.20210064

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Adenoid hypertrophy in children with epilepsy is rarely reported. This paper analyzes the clinical characteristics and incidence of adenoid hypertrophy in children with epilepsy.Methods The clinical data in children with epilepsy from December 2014 to April 2020 in Shenzhen Children's hospital were analyzed retrospectively.Results There were 449 cases diagnosed with adenoid hypertrophy (2.74%) in 16387 children with epilepsy. Among 449 cases of adenoid hypertrophy, 276 males (61.47%) and 173 females (38.53%). The age distribution was: 28 days to 1 year old, 8 cases (2%); 1-3 years old, 78 cases (17%); 3-6 years old 167 cases (37%); 6-12 years old, 153 cases (34%); 12-18 years old, 43 cases (10%). In 40 patients the IgG antibody were positive for EB capsid antigen in 25 (62.5%). In 56 cases of EB virus DNA were detected by fluorescence quantitative PCR, 25 (44.64%) positive, and 21/44 cases (47.72%) were positive by general nucleic acid detection of enteroviruses. The neutrophil reduction rate in peripheral blood was 42.19% in 673 tests, lymphocyteincreased in 292 (43.38%), platelet count increased in 307 (45.61%), abnormal in platelet hematocrit in 311 (46.21%); the mean volume of RBC was decreased in319 (47.39%) tests. The content of was reduced in 20/55 cases (36.36%). 25-hydroxy vitamin D was 33 (44.5%) decreased in 74 cases. The blood glucose was measured in 146 cases, 60 (41.09%) increased, total cholesterol was 31 (40.78%) increased in 76 cases, serum C peptide was 12 (29.26%) increased in 41 cases.Conclusion Adenoid hypertrophy in children with epilepsy may be related to infection, inflammation or immune disorder, which may cause nutritional, metabolic or internal environment disorders. Therefore, there is need of nursing and health education, transferring to specialized centers for diagnosis and treatment.

Citation： JIANG Yumei, LING Zhijuan, SU Ying, YE Jinghua, PAN Hongguang, LI Lan, YE Yuanzhen, HU Zhanqi, CAO Dezhi, LIAO Jianxiang. A preliminary investigation of adenoid hypertrophy in children with epilepsy. Journal of Epilepsy, 2021, 7(5): 397-401. doi: 10.7507/2096-0247.20210064 Copy

1.	Camfield P. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord, 2015, 17(2): 117-123.
2.	李桃利. 癫痫儿童神经精神共患病的研究进展. 复旦学报(医学版), 2018, 45(4): 578-584, 597.
3.	Joosten KF, Larramona H, Miano S, et al. How do we recognize the child with OSAS?. PediatrPulmonol, 2017, 52(2): 260-271.
4.	元芳芳, 康天, 陈惠军, 等. 儿童注意缺陷多动障碍及其共患病临床分析. 新乡医学院学报, 2019, 36(12): 1152-1154, 1158.
5.	杨一海, 刘丕松, 刘英. 儿童腺样体肥大与EB病毒感染的相关性分析. 山西大同大学学报(自然科学版), 2018, 34(4): 58-59, 65.
6.	韩婷. 儿童慢性扁桃体炎和腺样体肥大EB病毒感染特点的研究. 山东: 青岛大学, 2019, 硕士论文.
7.	吕梦颖, 卢大松, 冯勇军, 等. 腺样体肥大患者围手术期医院感染病原学特点及影响因素分析. 中华医院感染学杂志, 2018, 28(1): 81-83.
8.	翟长文, 王纾宜. EB病毒在原发性扁桃体弥漫大B细胞淋巴瘤(PT腺样体肥大并发分泌性中耳炎儿童的淋巴细胞亚群分布[DLBCL)中的表达及其临床意义. 复旦学报(医学版), 2014, 41(2): 210-215.
9.	张迎俊, 袁菲, 刘颖慧, 等. 腺样体肥大儿童的变应原检测及病因探讨. 临床耳鼻咽喉头颈外科杂志, 2017, 031(007): 549-551.
10.	Uludag I F, Duksal T, Tiftikcioglu B I, et al. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015, 26: 22-25.
11.	Singh Tanveer, Kaur Taranjot, Goel Rajesh Kumar. Ferulic acid supplementation for management of depression in epilepsy. Neurochemical research, 2017, 42(10): 2940-2948.
12.	操金金, 崔凡, 刘福荣, 等. 降钙素原、C-反应蛋白、红细胞沉降率与白细胞计数联合检测在呼吸道感染诊断中的应用价值. 中国医药导报, 2020, 17(10): 161-164.
13.	柳荫, 杨娜. 腺样体肥大并发分泌性中耳炎儿童的淋巴细胞亚群分布. 实用医学杂志, 2017, 033(14): 2376-2379.
14.	Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simpleparameter of systemic inflammation and stress in critically ill. Bratisl LekListy, 2001, 102(1): 5-14.
15.	刘红钊, 张保朝, 张小林, 等. 血小板体积指数、脑灌注压对动脉瘤性蛛网膜下腔出血后患者迟发性脑缺血的预测价值. 实用医学杂志, 2019, 35(19): 3018-3021.
16.	Jeppesen Jesper, Beniczky Sándor, Johansen Peter, et al. Exploring the capability of wireless near infrared spectroscopy as a portable seizure detection device for epilepsy patients. Seizure, 2015, 26: 43-88.
17.	刘钊, 韩俊霞, 朱晓涵, 等. 应用功能近红外脑成像对伴中央颞区棘波的良性癫痫患儿数学计算认知功能的研究. 北京医学, 2019, 41(11): 980-983.
18.	刘巍巍, 马建荣, 邹丽颖. 经皮氧气二氧化碳分压监测在呼吸支持新生儿的应用. 北京医学, 2020, 42(3): 193-196.
19.	闫中峰, 夏文菁, 李红, 等. 血气分析对发作性意识障碍的鉴别诊断意义. 中国实验诊断学, 2020, 24(2): 208-211.
20.	汪义胜, 陈开兰. MCV、MCH及RDW检测在小儿缺铁性贫血临床诊断价值的研究. 当代医学, 2019, 25(12): 38-40.
21.	杨瑞祥. 血清C肽、皮质醇、胰岛素与早产儿血糖代谢紊乱的临床研究. 中国实验诊断学, 2018, 22(8): 1410-1412.
22.	Söylemez E, Öztürk O, Baslo SA, et al. Metabolic syndrome andobstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020 Oct;111: 107296. doi: 10.1016/j.yebeh.2020.107296. Epub 2020Aug 6.
23.	傅蓉, 李鸣, 杨紫茜, 等. 癫痫伴发抑郁的研究进展. 中风与神经疾病杂志, 2019, 36(10): 955-957.
24.	Al-Abri M, Al-Asmi A, Al-Shukairi A, et al. Frequency of obstructive sleep apnea syndrome among patients with epilepsy attending a tertiary neurology clinic. Oman Med J, 2015, 30(1): 31-35.
25.	Miano S, Paolino MC, Peraita-Adrados R, et al. Prevalence of EEG paroxysmal activity ina population of children withobstructive sleep apnea syndrome. Sleep, 2009, 32(4): 522-529.
26.	Miano S, Bachiller C, Gutiérrez M, et al. Paroxysmal activity and seizures associated with sleep breathing disorder inchildren: a possible overlap between diurnal and nocturnal symptoms. Seizure, 2010, 19(9): 547-552.
27.	Oliveira AJ, Zamagni M, Dolso P, et al. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol, 2000, 111 Suppl2: S141-145.
28.	姜涛. 儿童腺样体肥大的MR表现在癫痫诊疗中的应用价值初探. 医学理论与实践, 2016, 29(12): 1631-1632.

1. Camfield P. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord, 2015, 17(2): 117-123.
2. 李桃利. 癫痫儿童神经精神共患病的研究进展. 复旦学报(医学版), 2018, 45(4): 578-584, 597.
3. Joosten KF, Larramona H, Miano S, et al. How do we recognize the child with OSAS?. PediatrPulmonol, 2017, 52(2): 260-271.
4. 元芳芳, 康天, 陈惠军, 等. 儿童注意缺陷多动障碍及其共患病临床分析. 新乡医学院学报, 2019, 36(12): 1152-1154, 1158.
5. 杨一海, 刘丕松, 刘英. 儿童腺样体肥大与EB病毒感染的相关性分析. 山西大同大学学报(自然科学版), 2018, 34(4): 58-59, 65.
6. 韩婷. 儿童慢性扁桃体炎和腺样体肥大EB病毒感染特点的研究. 山东: 青岛大学, 2019, 硕士论文.
7. 吕梦颖, 卢大松, 冯勇军, 等. 腺样体肥大患者围手术期医院感染病原学特点及影响因素分析. 中华医院感染学杂志, 2018, 28(1): 81-83.
8. 翟长文, 王纾宜. EB病毒在原发性扁桃体弥漫大B细胞淋巴瘤(PT腺样体肥大并发分泌性中耳炎儿童的淋巴细胞亚群分布[DLBCL)中的表达及其临床意义. 复旦学报(医学版), 2014, 41(2): 210-215.
9. 张迎俊, 袁菲, 刘颖慧, 等. 腺样体肥大儿童的变应原检测及病因探讨. 临床耳鼻咽喉头颈外科杂志, 2017, 031(007): 549-551.
10. Uludag I F, Duksal T, Tiftikcioglu B I, et al. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015, 26: 22-25.
11. Singh Tanveer, Kaur Taranjot, Goel Rajesh Kumar. Ferulic acid supplementation for management of depression in epilepsy. Neurochemical research, 2017, 42(10): 2940-2948.
12. 操金金, 崔凡, 刘福荣, 等. 降钙素原、C-反应蛋白、红细胞沉降率与白细胞计数联合检测在呼吸道感染诊断中的应用价值. 中国医药导报, 2020, 17(10): 161-164.
13. 柳荫, 杨娜. 腺样体肥大并发分泌性中耳炎儿童的淋巴细胞亚群分布. 实用医学杂志, 2017, 033(14): 2376-2379.
14. Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simpleparameter of systemic inflammation and stress in critically ill. Bratisl LekListy, 2001, 102(1): 5-14.
15. 刘红钊, 张保朝, 张小林, 等. 血小板体积指数、脑灌注压对动脉瘤性蛛网膜下腔出血后患者迟发性脑缺血的预测价值. 实用医学杂志, 2019, 35(19): 3018-3021.
16. Jeppesen Jesper, Beniczky Sándor, Johansen Peter, et al. Exploring the capability of wireless near infrared spectroscopy as a portable seizure detection device for epilepsy patients. Seizure, 2015, 26: 43-88.
17. 刘钊, 韩俊霞, 朱晓涵, 等. 应用功能近红外脑成像对伴中央颞区棘波的良性癫痫患儿数学计算认知功能的研究. 北京医学, 2019, 41(11): 980-983.
18. 刘巍巍, 马建荣, 邹丽颖. 经皮氧气二氧化碳分压监测在呼吸支持新生儿的应用. 北京医学, 2020, 42(3): 193-196.
19. 闫中峰, 夏文菁, 李红, 等. 血气分析对发作性意识障碍的鉴别诊断意义. 中国实验诊断学, 2020, 24(2): 208-211.
20. 汪义胜, 陈开兰. MCV、MCH及RDW检测在小儿缺铁性贫血临床诊断价值的研究. 当代医学, 2019, 25(12): 38-40.
21. 杨瑞祥. 血清C肽、皮质醇、胰岛素与早产儿血糖代谢紊乱的临床研究. 中国实验诊断学, 2018, 22(8): 1410-1412.
22. Söylemez E, Öztürk O, Baslo SA, et al. Metabolic syndrome andobstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020 Oct;111: 107296. doi: 10.1016/j.yebeh.2020.107296. Epub 2020Aug 6.
23. 傅蓉, 李鸣, 杨紫茜, 等. 癫痫伴发抑郁的研究进展. 中风与神经疾病杂志, 2019, 36(10): 955-957.
24. Al-Abri M, Al-Asmi A, Al-Shukairi A, et al. Frequency of obstructive sleep apnea syndrome among patients with epilepsy attending a tertiary neurology clinic. Oman Med J, 2015, 30(1): 31-35.
25. Miano S, Paolino MC, Peraita-Adrados R, et al. Prevalence of EEG paroxysmal activity ina population of children withobstructive sleep apnea syndrome. Sleep, 2009, 32(4): 522-529.
26. Miano S, Bachiller C, Gutiérrez M, et al. Paroxysmal activity and seizures associated with sleep breathing disorder inchildren: a possible overlap between diurnal and nocturnal symptoms. Seizure, 2010, 19(9): 547-552.
27. Oliveira AJ, Zamagni M, Dolso P, et al. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol, 2000, 111 Suppl2: S141-145.
28. 姜涛. 儿童腺样体肥大的MR表现在癫痫诊疗中的应用价值初探. 医学理论与实践, 2016, 29(12): 1631-1632.

Journal of Epilepsy

A preliminary investigation of adenoid hypertrophy in children with epilepsy

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