ILAE 发作和癫痫分类：对新生儿癫痫发作的调整—ILAE 新生儿癫痫特别工作组制定_Journal of Epilepsy

Authors：

 Ronit MPressler , Maria RobertaCilio , Eli MMizrahi , 刘旸　译 , 吴逊　审

Corresponding author：

Ronit MPressler, Email: ronit.pressler@gosh.nhs.uk

Keywords：

分类; EEG（脑电图）; 癫痫; 新生儿发作; 症状学

DOI：

10.7507/2096-0247.20210074

Video：

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Abstract Full text Figures/Tables Video References Cited by

发作是新生儿期最常见的神经急症，与婴儿和儿童不同，癫痫通常是由急性病因引起的诱发性发作，并且可能仅仅表现为脑电图异常。特别需要提出的是，年龄较大的儿童和成人癫痫发作和癫痫的分类方案可能不适用于新生儿发作。因此，国际抗癫痫联盟（ILAE）成立了新生儿癫痫工作组，改进 2017 年 ILAE 发作和癫痫分类，以适用于新生儿。新生儿分类框架强调了脑电图（EEG）在新生儿发作诊断中的作用，并包括了与该年龄组适应的发作类型的分类。发作的类型是由主要的临床特征决定的。许多新生儿发作仅有脑电图表现，没有明显的临床特征；因此，这些都包括在推荐的分类中。没有相关脑电图的临床事件不包括在内。由于新生儿期发作已被证明有局灶性起源的发作，因此没有必要将其划分为局灶性和广泛性。发作可以有运动（自发性、阵挛性、癫痫性痉挛、肌阵挛、强直）、非运动性（自主神经、行为停止）或继发表现。该分类允许用户在对这个年龄组的癫痫发作进行分类时选择详细程度。

Citation： Ronit MPressler, Maria RobertaCilio, Eli MMizrahi, 刘旸　译, 吴逊　审. ILAE 发作和癫痫分类：对新生儿癫痫发作的调整—ILAE 新生儿癫痫特别工作组制定. Journal of Epilepsy, 2021, 7(5): 445-456. doi: 10.7507/2096-0247.20210074 Copy

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2. WHO. Pretermbirth, fact sheet, 2016.
3. Lanska MJ, Lanska DJ, Baumann RJ, et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology, 1995, 45(4): 724-732.
4. Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
5. Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr, 1999, 134(1): 71-75.
6. Fisher RS, Cross JH, D'Souza C, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia, 2017, 58(4): 531-542.
7. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
8. Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.
9. Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology, 1987, 37(12): 1837-1844.
10. Scher MS, Alvin J, Gaus L, et al. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol, 2003, 28(4): 277-280.
11. Nash KB, Bonifacio SL, Glass HC, et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology, 2011, 76(6): 556-262.
12. Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
13. Galanopoulou AS, Moshe SL. In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies. Biomarkers Med, 2011, 5(5): 615-628.
14. Haut SR, Veliskova J, Moshe SL. Susceptibility of immature and adult brains to seizure effects. Lancet Neurol, 2004, 3(10): 608-617.
15. Murray DM, Boylan GB, Ali I, et al. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed, 2008, 93(3): F187-F191.
16. Boylan GB, Pressler RM, Pressler RM, et al. Outcome of electroclinical, electrographic, andclinical seizures in the newborn infant. Dev Med Child Neurol, 1999, 41(12): 819-825.
17. Boylan GB, Rennie JM, Pressler RM, et al. Phenobarbitone, neonatal seizures, and video-EEG. Arch Dis Child Fetal Neonatal Ed, 2002, 86(3): F165-F170.
18. Shellhaas RA, Chang T, Tsuchida T, et al. The American clinical neurophysiology society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-607.
19. Hahn CD, Riviello JJ. Neonatal Seizures and EEG. NeoReviews, 2004, 5(8): e350-e355.
20. Mathieson SR, Livingstone V, Low E, et al. Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection. Clin Neurophysiol, 2016, 127(10): 3343-3350.
21. Weiner SP, Painter MJ, Geva D, et al. Neonatal seizures: electroclinical dissociation. Pediatr Neurol, 1991, 7(5): 363-368.
22. Kharoshankaya L, Stevenson NJ, Livingstone V, et al. Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. Dev Med Child Neurol, 2016, 58(12): 1242-1208.
23. McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology, 2000, 55(4): 506-513.
24. Miller SP, Weiss J, Barnwell A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology, 2002, 58(4): 542-548.
25. Srinivasakumar P, Zempel J, Trivedi S, et al. Treating EEG seizures in hypoxic ischemic encephalopathy: a randomized controlled trial. Pediatrics, 2015, 136(5): e1302-e1309.
26. van Rooij LGM, Toet MC, van Huffelen AC, et al. Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial. Pediatrics, 2010, 125(2): e358-e366.
27. Tsuchida TN, Wusthoff CJ, Shellhaas RA, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the american clinical neurophysiology society critical care monitoring committee. J Clin Neurophysiol, 2013, 30(2): 161-173.
28. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 512-521.
29. Burke JB. The prognostic significance of neonatal convulsions. Arch Dis Child, 1954, 29(146): 342-345.
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