Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy_Journal of Epilepsy

Authors：

 XIA Xinjian ¹ , LI Yaobin ¹ , WANG Hui ¹ , LI Xiang ² , LI Ning ¹

1. Shouguang people's Hospital Image Center, Shandong, Shouguang 262700 , China;
2. Shouguang people's Hospital Internal Medicine-Neurology, Shandong, Shouguang 262700, China;

Corresponding author：

XIA Xinjian, Email: xxjxhm@163.com

Keywords：

Idiopathic Generalized Epilepsy; Magnetic Resonance Imaging; Cortical Thickness; Laterality

DOI：

10.7507/2096-0247.202212008

Video：

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Objective To construct a map of cerebral cortex thickness in Idiopathic Generalized Epilepsy (IGE) diagnosed at the first visit, using T1-weighted brain magnetic resonance imaging and advanced image analysis software. Methods High-resolution three-dimensional T1 images were obtained from 27 IGE patients diagnosed at the first visit and 29 normal controls in Shouguang People's Hospital from January 1, 2022 to December 31, 2021. The location recognition calculation system of the Freesurfer software was used to calculate the values of cortical thickness in each brain region, and the cortical thickness values were transformed into a brain atlas using the image analysis software. A differential brain atlas was generated using the two-sample t-test to analyze the difference in cortical thickness between IGE patients and normal controls. Paired t-test was used for within-group comparison to explore changes of cortical thickness laterality. Results In the IGE brain atlas, the brain regions with higher cortical thickness were the right left temporal pole, the right left entorhinal cortex, the head of the right anterior cingulate gyrus, the right and left insular lobe, the right and left middle temporal gyrus, the right inferior temporal gyrus, the head of the left anterior cingulate gyrus, the left tail of the anterior cingulate gyrus, the left inferior temporal gyrus, the left and right fusiform gyrus, and the left frontal pole. The areas with lower cortical thickness were the right and left paracalcaric gyrus, the right and left cuneiform lobe, the left and right lingual gyrus, the left and right posterior central gyrus, the left lateral occipital gyrus, and the right and left superior parietal gyrus. The distribution of cortical thickness of the IGE group was comparable to the cortical thickness atlas of the normal control. Compared with normal control, the areas with changes of cortical thickness in the IGE group were bilateral superior frontal gyrus, bilateral posterior central gyrus, bilateral anterior central gyri, bilateral lingual gyri, left cuneiform lobe, bilateral entorhinal cortex and temporal pole. The brain areas with laterality of cortical thickness between hemispheres in the IGE group were the tail of anterior cingulate gyrus, cuneiform lobe, inferior parietal gyrus, lateral occipital gyrus, posterior central gyrus, head of anterior cingulate gyrus, and superior marginal gyrus. Compared with normal control, the IGE group has decreased number of brain regions with laterality of cortical thickness. Conclusion The present study revealed the distribution and laterality of cerebral cortical thickness map in early idiopathic generalized epilepsy, which provides imaging structural basis for brain research in the future.

Citation： XIA Xinjian, LI Yaobin, WANG Hui, LI Xiang, LI Ning. Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy. Journal of Epilepsy, 2023, 9(2): 112-118. doi: 10.7507/2096-0247.202212008 Copy

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2.	吴娇南, 吕心怡, 蒋玉宝, 等. 特发性全面性癫痫患者双眼竞争的研究. 立体定向和功能性神经外科杂志, 2021, 34(4): 199-203.
3.	Gesche J, Hjalgrim H, Rubboli G, et al. The clinical spectrum of familial and sporadic idiopathic generalized epilepsy. Epilepsy Research, 2020, 165: 74-79.
4.	吕锦, 曲春生, 蓝丽康. OTX1基因多态性与特发性癫痫的相关性研究. 浙江实用医学, 2020, 25(1): 33-35.
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6.	陈涛, 贾文霄, 罕迦尔别克·库锟, 等. 颞叶癫痫脑结构改变的MRI研究. 实用放射学杂志, 2022, 38(7): 1049-1052.
7.	郝竞汝, 翁艺菲, 张其锐, 等. 内侧颞叶癫痫患者丘脑核团表面形状改变的结构MRI研究. 中华解剖与临床杂志, 2021, 26(4): 373-378.
8.	杨钒, 贾文霄, 罕迦尔别克·库锟, 等. 基于体素的MRI阴性成人颞叶癫痫灰质结构研究. 影像诊断与介入放射学, 2021, 30(5): 330-336.
9.	Perani S, Tierney TM, Centeno M, et al. Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia, 2018, 59(1): 226-234.
10.	Kong XZ, Mathias SR, Guadalupe T, et al. Mapping cortical brain asymmetry in 17141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A, 2018, 115(22): E5154-63.
11.	Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(20): 11050-11055.
12.	王伟. 健康成人大脑灰质图谱的建立研究. 中国微侵袭神经外科杂志, 2020, 25(10): 433-436.
13.	陈颖, 朱玉连, 胡瑞萍, 等. 经颅磁刺激抑制健康人初级运动皮质后双侧中央前回精细分区的脑有效连接变化. 中华物理医学与康复杂志, 2021, 43(3): 211-214.
14.	Park K M, Kim T H, Han Y H, et al. Brain morphology in juvenile myoclonic epilepsy and absence seizures. Acta Neurologica Scandinavica, 2016, 133(2): 111-118.
15.	韩菊萍, 黄亚锦, 王小倩, 等. 儿童失神癫痫结构及功能磁共振成像研究进展. 中国医药, 2022, 017(001): 149-152.
16.	Overvliet GM, Besseling R, Jansen J, et al. Early onset of cortical thinning in children with rolandic epilepsy. Neuroimage Clinical, 2013, 2(Complete): 434-439.
17.	Pedreschi N, Bernard C, Clawson W, et al. Dynamic core-periphery structure of information sharing networks in entorhinal cortex and hippocampus. Network Neuroscience, 2020, 4(1): 1-42.
18.	张静, 梁佩鹏, 赵莹, 等. 高分辨MRI测量中国健康成人内嗅皮层体积. 中国医学影像技术, 2021, 37(2): 165-168.
19.	Alhusaini S, Ronan L, Scanlon C, et al. Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy. Epilepsia, 2014, 54(9): e138-e141.
20.	Ronan L, Alhusaini S, Scanlon C, et al. Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI. Epilepsia, 2012, 53(4): 651-658.
21.	夏新建, 孙杉杉, 王辉, 等. 不同年龄段成人大脑皮质厚度偏侧性的MRI研究. 中华解剖与临床杂志, 2019, (6): 525-530.

1. Toga AW, Thompson PM, Mori S, et al. Towards multimodal atlases of the human brain. Nat Rev Neuro-sci, 2006, 7(12): 952-966.
2. 吴娇南, 吕心怡, 蒋玉宝, 等. 特发性全面性癫痫患者双眼竞争的研究. 立体定向和功能性神经外科杂志, 2021, 34(4): 199-203.
3. Gesche J, Hjalgrim H, Rubboli G, et al. The clinical spectrum of familial and sporadic idiopathic generalized epilepsy. Epilepsy Research, 2020, 165: 74-79.
4. 吕锦, 曲春生, 蓝丽康. OTX1基因多态性与特发性癫痫的相关性研究. 浙江实用医学, 2020, 25(1): 33-35.
5. Glahn DC, Thompson PM, Blangero J. Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Human Brain Mapping, 2010, 28(6): 488-501.
6. 陈涛, 贾文霄, 罕迦尔别克·库锟, 等. 颞叶癫痫脑结构改变的MRI研究. 实用放射学杂志, 2022, 38(7): 1049-1052.
7. 郝竞汝, 翁艺菲, 张其锐, 等. 内侧颞叶癫痫患者丘脑核团表面形状改变的结构MRI研究. 中华解剖与临床杂志, 2021, 26(4): 373-378.
8. 杨钒, 贾文霄, 罕迦尔别克·库锟, 等. 基于体素的MRI阴性成人颞叶癫痫灰质结构研究. 影像诊断与介入放射学, 2021, 30(5): 330-336.
9. Perani S, Tierney TM, Centeno M, et al. Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia, 2018, 59(1): 226-234.
10. Kong XZ, Mathias SR, Guadalupe T, et al. Mapping cortical brain asymmetry in 17141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A, 2018, 115(22): E5154-63.
11. Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(20): 11050-11055.
12. 王伟. 健康成人大脑灰质图谱的建立研究. 中国微侵袭神经外科杂志, 2020, 25(10): 433-436.
13. 陈颖, 朱玉连, 胡瑞萍, 等. 经颅磁刺激抑制健康人初级运动皮质后双侧中央前回精细分区的脑有效连接变化. 中华物理医学与康复杂志, 2021, 43(3): 211-214.
14. Park K M, Kim T H, Han Y H, et al. Brain morphology in juvenile myoclonic epilepsy and absence seizures. Acta Neurologica Scandinavica, 2016, 133(2): 111-118.
15. 韩菊萍, 黄亚锦, 王小倩, 等. 儿童失神癫痫结构及功能磁共振成像研究进展. 中国医药, 2022, 017(001): 149-152.
16. Overvliet GM, Besseling R, Jansen J, et al. Early onset of cortical thinning in children with rolandic epilepsy. Neuroimage Clinical, 2013, 2(Complete): 434-439.
17. Pedreschi N, Bernard C, Clawson W, et al. Dynamic core-periphery structure of information sharing networks in entorhinal cortex and hippocampus. Network Neuroscience, 2020, 4(1): 1-42.
18. 张静, 梁佩鹏, 赵莹, 等. 高分辨MRI测量中国健康成人内嗅皮层体积. 中国医学影像技术, 2021, 37(2): 165-168.
19. Alhusaini S, Ronan L, Scanlon C, et al. Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy. Epilepsia, 2014, 54(9): e138-e141.
20. Ronan L, Alhusaini S, Scanlon C, et al. Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI. Epilepsia, 2012, 53(4): 651-658.
21. 夏新建, 孙杉杉, 王辉, 等. 不同年龄段成人大脑皮质厚度偏侧性的MRI研究. 中华解剖与临床杂志, 2019, (6): 525-530.

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Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy

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