Research progress on the role of Krüppel-like factor 4 in neurological diseases_Journal of Epilepsy

Authors：

YANG Yang ,  SUN Hongying

1. Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China;

Corresponding author：

SUN Hongying, Email: sunhongying2004@sina.com

Keywords：

Krüppel-like factor 4; Neurological disorders; Epilepsy; Alzheimer’s disease; Ischemic stroke

DOI：

10.7507/2096-0247.202312003

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Krüppel-like factor 4 (KLF4) is a member of the sample Kruppel transcription factor protein family, is an evolutionary conservative contain zinc finger transcription factors, involved in regulating many cellular processes, such as cell growth, proliferation, differentiation and invasion, KLF4 expression in a variety of tissues and cells in the body, has widely in many physiological and pathological conditions. Many studies have shown that KLF4 is involved in neurobiological processes such as neuroinflammation, oxidative stress, apoptosis and axon regeneration, and is closely related to a variety of nervous system diseases such as epilepsy, stroke, and Alzheimer’s disease. Now KLF4 in its role in the development of nervous system diseases were reviewed, help to understand the pathogenesis of the disease and clinical treatment for diseases of the nervous system to provide potential targets.

Citation： YANG Yang, SUN Hongying. Research progress on the role of Krüppel-like factor 4 in neurological diseases. Journal of Epilepsy, 2024, 10(2): 141-146. doi: 10.7507/2096-0247.202312003 Copy

1.	He Z, He J, Xie K. KLF4 transcription factor in tumorigenesis. Cell Death Discov, 2023, 9(1): 118.
2.	Ghaleb AM, Yang VW. Krüppel-like factor 4 (KLF4): what we currently know. Gene, 2017, 611: 27-37.
3.	Evans PM, Liu C. Roles of Krüppel‐like factor 4 in normal homeostasis, cancer and stem cells. Acta biochimica et biophysica Sinica, 2008, 40(7): 554-564.
4.	Yang C, Xiao X, Huang L, et al. Role of Kruppel-like factor 4 in atherosclerosis. Clin Chim Acta, 2021, 512: 135-141.
5.	Hauser RM, Henshall DC, Lubin FD. The epigenetics of epilepsy and its progression. The Neuroscientist, 2018, 24(2): 186-200.
6.	Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nature Reviews Neuroscience, 2013, 14(5): 337-349.
7.	Chen Y, Chen J, Chen Y, et al. miR-146a/KLF4 axis in epileptic mice: a novel regulator of synaptic plasticity involving STAT3 signaling. Brain Research, 2022, 1790: 147988.
8.	刘黔飞, 刘瑛, 叶兰, 等. 小胶质细胞参与癫痫发病机制的研究进展. 癫痫与神经电生理学杂志, 2023, 32(4): 225-228.
9.	许文博. 条件性KLF4敲除小鼠的建立及癫痫分子发病机制研究. 吉林大学, 2022, 硕士学位论文.
10.	郭家伶. KLF4在PTZ点燃模型大鼠海马苔藓纤维出芽过程中的动态表达. 中南大学, 2013, 硕士学位论文.
11.	李莉. PTZ点燃模型大鼠海马P53表达与苔藓纤维出芽关系的研究. 中南大学, 2014, 硕士学位论文.
12.	刘伟. 转录因子KLF-4的抗癫痫作用及其机制研究. 吉林大学, 2019, 硕士学位论文.
13.	Zhu S, Tai C, MacVicar BA, et al. Glutamatergic stimulation triggers rapid Krüpple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity. Brain Res, 2009, 1250: 49-62.
14.	刘晓军, 雷梅芳, 张玉琴. 即早基因c-fos与神经系统疾病的研究进展. 天津医科大学学报, 2011, 17(1): 137-139.
15.	张欣. GABA-A受体介导的KLF4对癫痫的调控机制的研究. 吉林大学, 2019, 硕士学位论文.
16.	Shimazaki K, Kobari T, Oguro K, et al. Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice. Mol Ther Methods Clin Dev, 2019(13): 180-186.
17.	Jiang S, Nandy P, Wang W, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener, 2018, 13(1): 5.
18.	Mattson MP. Pathways towards and away from Alzheimer's disease. Nature, 2004, 430(7000): 631-639.
19.	Chen Z, Zhong C. Oxidative stress in Alzheimer's disease. Neurosci Bull, 2014, 30(2): 271-281.
20.	Li L, Zi X, Hou D, et al. Krüppel-like factor 4 regulates amyloid-β (Aβ)-induced neuroinflammation in Alzheimer's disease. Neurosci Lett, 2017(643): 131-137.
21.	张译丹, 伊然, 董齐, 等. Krüppel样转录因子家族在阿尔茨海默病发病机制中的作用研究进展. 中国临床神经科学, 2017, 25(4): 458-464+480.
22.	Li Z, Zhao J, Li Q, et al. KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway. Cell Stress Chaperones, 2010, 15(6): 905-912.
23.	Su C, Sun F, Cunningham RL, et al. ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning. Age (Dordr), 2014, 36(4): 9685.
24.	Cheng Z, Zou X, Jin Y, et al. The role of KLF4 in Alzheimer's disease. Front Cell Neurosci, 2018, 12: 325.
25.	Peters DG, Connor JR, Meadowcroft MD. The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin. Neurobiol Dis, 2015, 81: 49-65.
26.	Li H, Zhang C, Shen H, et al. Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons. Sci Rep, 2017, 7(1): 5745.
27.	Guzik A, Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn), 2017, 23(1): 15-39.
28.	Wu S, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394-405.
29.	DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Inflammatory responses after ischemic stroke. Semin Immunopathol, 2022, 44(5): 625-648.
30.	Zhang X, Wang L, Han Z, et al. KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke. J Neuroinflammation, 2020, 17(1): 107.
31.	Huang T, Yin J, Ren S, et al. Protective effects of KLF4 on blood-brain barrier and oxidative stress after cerebral ischemia-reperfusion in rats through the Nrf2/Trx1 pathway. Cytokine, 2023, 169: 156288.
32.	Yang H, Xi X, Zhao B, et al. KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1. Biochem Biophys Res Commun, 2018, 495(3): 2376-2382.
33.	Wang C, Li L. The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke. J Neuroinflammation, 2023, 20(1): 44.

1. He Z, He J, Xie K. KLF4 transcription factor in tumorigenesis. Cell Death Discov, 2023, 9(1): 118.
2. Ghaleb AM, Yang VW. Krüppel-like factor 4 (KLF4): what we currently know. Gene, 2017, 611: 27-37.
3. Evans PM, Liu C. Roles of Krüppel‐like factor 4 in normal homeostasis, cancer and stem cells. Acta biochimica et biophysica Sinica, 2008, 40(7): 554-564.
4. Yang C, Xiao X, Huang L, et al. Role of Kruppel-like factor 4 in atherosclerosis. Clin Chim Acta, 2021, 512: 135-141.
5. Hauser RM, Henshall DC, Lubin FD. The epigenetics of epilepsy and its progression. The Neuroscientist, 2018, 24(2): 186-200.
6. Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nature Reviews Neuroscience, 2013, 14(5): 337-349.
7. Chen Y, Chen J, Chen Y, et al. miR-146a/KLF4 axis in epileptic mice: a novel regulator of synaptic plasticity involving STAT3 signaling. Brain Research, 2022, 1790: 147988.
8. 刘黔飞, 刘瑛, 叶兰, 等. 小胶质细胞参与癫痫发病机制的研究进展. 癫痫与神经电生理学杂志, 2023, 32(4): 225-228.
9. 许文博. 条件性KLF4敲除小鼠的建立及癫痫分子发病机制研究. 吉林大学, 2022, 硕士学位论文.
10. 郭家伶. KLF4在PTZ点燃模型大鼠海马苔藓纤维出芽过程中的动态表达. 中南大学, 2013, 硕士学位论文.
11. 李莉. PTZ点燃模型大鼠海马P53表达与苔藓纤维出芽关系的研究. 中南大学, 2014, 硕士学位论文.
12. 刘伟. 转录因子KLF-4的抗癫痫作用及其机制研究. 吉林大学, 2019, 硕士学位论文.
13. Zhu S, Tai C, MacVicar BA, et al. Glutamatergic stimulation triggers rapid Krüpple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity. Brain Res, 2009, 1250: 49-62.
14. 刘晓军, 雷梅芳, 张玉琴. 即早基因c-fos与神经系统疾病的研究进展. 天津医科大学学报, 2011, 17(1): 137-139.
15. 张欣. GABA-A受体介导的KLF4对癫痫的调控机制的研究. 吉林大学, 2019, 硕士学位论文.
16. Shimazaki K, Kobari T, Oguro K, et al. Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice. Mol Ther Methods Clin Dev, 2019(13): 180-186.
17. Jiang S, Nandy P, Wang W, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener, 2018, 13(1): 5.
18. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature, 2004, 430(7000): 631-639.
19. Chen Z, Zhong C. Oxidative stress in Alzheimer's disease. Neurosci Bull, 2014, 30(2): 271-281.
20. Li L, Zi X, Hou D, et al. Krüppel-like factor 4 regulates amyloid-β (Aβ)-induced neuroinflammation in Alzheimer's disease. Neurosci Lett, 2017(643): 131-137.
21. 张译丹, 伊然, 董齐, 等. Krüppel样转录因子家族在阿尔茨海默病发病机制中的作用研究进展. 中国临床神经科学, 2017, 25(4): 458-464+480.
22. Li Z, Zhao J, Li Q, et al. KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway. Cell Stress Chaperones, 2010, 15(6): 905-912.
23. Su C, Sun F, Cunningham RL, et al. ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning. Age (Dordr), 2014, 36(4): 9685.
24. Cheng Z, Zou X, Jin Y, et al. The role of KLF4 in Alzheimer's disease. Front Cell Neurosci, 2018, 12: 325.
25. Peters DG, Connor JR, Meadowcroft MD. The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin. Neurobiol Dis, 2015, 81: 49-65.
26. Li H, Zhang C, Shen H, et al. Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons. Sci Rep, 2017, 7(1): 5745.
27. Guzik A, Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn), 2017, 23(1): 15-39.
28. Wu S, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394-405.
29. DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Inflammatory responses after ischemic stroke. Semin Immunopathol, 2022, 44(5): 625-648.
30. Zhang X, Wang L, Han Z, et al. KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke. J Neuroinflammation, 2020, 17(1): 107.
31. Huang T, Yin J, Ren S, et al. Protective effects of KLF4 on blood-brain barrier and oxidative stress after cerebral ischemia-reperfusion in rats through the Nrf2/Trx1 pathway. Cytokine, 2023, 169: 156288.
32. Yang H, Xi X, Zhao B, et al. KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1. Biochem Biophys Res Commun, 2018, 495(3): 2376-2382.
33. Wang C, Li L. The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke. J Neuroinflammation, 2023, 20(1): 44.

Previous Article
Research of the application status of event-related potentials in epilepsy
Next Article
Effects of anti-seizure medications on postictal state of epilepsy

Journal of Epilepsy

Research progress on the role of Krüppel-like factor 4 in neurological diseases

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content