迷走神经刺激治疗儿童药物难治性癫痫的中国专家共识_Journal of Epilepsy

Authors：

 中国医师协会神经调控专业委员会 , 中国抗癫痫协会神经调控专业委员会

执笔吴晔（北京大学第一医院），张凯（首都医科大学附属北京天坛医院），刘庆祝（北京大学第一医院），邵晓秋（首都医科大学附属北京天坛医院），栾国明（首都医科大学三博脑科医院），张建国（首都医科大学附属北京天坛医院）;

Corresponding author：

中国医师协会神经调控专业委员会, Email: zjguo73@126.com

Keywords：

DOI：

10.7507/2096-0247.202410013

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

1.	Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia, 1998, 39(7): 677-686.
2.	中国医师协会神经内科分会癫(癎)专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
3.	中国抗癫痫协会神经调控专业委员会, 中国医师协会神经调控专业委员会, 中华医学会神经外科分会神经生理学组. 迷走神经刺激治疗药物难治性癫痫的中国专家共识. 癫痫杂志, 2021, 7(3): 191-196.
4.	McMillan SS, King M, Tully MP. How to use the nominal group and Delphi techniques. Int J Clin Pharm, 2016, 38(3): 655-662.
5.	Jain P, Arya R. Vagus nerve stimulation and seizure outcomes in pediatric refractory epilepsy: systematic review and meta-analysis. Neurology, 2021, 96(22): 1041-1051.
6.	Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: a European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
7.	Feygina AA, Koshelyaevskaya YN, Dibué M, et al. Efficacy and safety following two or more years of vagus nerve stimulation (VNS Therapy) in pediatric patients with drug-resistant epilepsy enrolled in a Russian VNS Registry. Brain & Behavior, 2023, 13(7): e3076.
8.	Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy & Behavior, 2020, 112: 107373.
9.	Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response: a review. JNS, 2011, 115(6): 1248-1255.
10.	Alexopoulos AV, Kotagal P, Loddenkemper T, et al. Long-term results with vagus nerve stimulation in children with pharmacoresistant epilepsy. Seizure, 2006, 15(7): 491-503.
11.	Benifla M, Rutka JT, Logan W, et al. Vagal nerve stimulation for refractory epilepsy in children: indications and experience at the hospital for sick children. Childs Nerv Syst, 2006, 22(8): 1018-1026.
12.	Murphy JV, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: The first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560.
13.	Helmers SL, Wheless JW, Frost M, et al. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective Study. J Child Neurol, 2001, 16(11): 843-848.
14.	Sauer V, Glaser M, Ellwardt E, et al. Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy. Epilepsy & Behavior, 2024, 150: 109562.
15.	Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: a 10–17 year follow-up study. Seizure, 2018, 59: 41-47.
16.	Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2018, 79(02): 152-158.
17.	Hilderink J, Tjepkema-Cloostermans MC, Geertsema A, et al. Predicting success of vagus nerve stimulation (VNS) from EEG symmetry. Seizure, 2017, 48: 69-73.
18.	Ching J, Khan S, White P, et al. Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients. British Journal of Neurosurgery, 2013, 27(2): 228-234.
19.	Scherrmann J, Hoppe C, Kral T, et al. Vagus nerve stimulation: clinical experience in a large patient series. Journal of Clinical Neurophysiology, 2001, 18(5): 408-414.
20.	Amar AP, DeGiorgio CM, Tarver WB, et al. Long-term multicenter experience with vagus nerve stimulation for intractable partial seizures. Stereotact Funct Neurosurg, 1999, 73(1-4): 104-108.
21.	Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
22.	Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
23.	Kostov KH, Kostov H, Larsson PG, et al. Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study. Epilepsia, 2022, 63(2): 414-425.
24.	Xie H, Ma J, Ji T, et al. Efficacy of vagus nerve stimulation in 95 children of drug-resistant epilepsy with structural etiology. Epilepsy & Behavior, 2023, 140: 109107.
25.	Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: a scoping review. Epilepsia, 2020, 61(10): 2069-2085.
26.	Zhang Y, Wang X, Tang C, et al. Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Journal of Neurosurgery, 2022, 136(3): 726-735.
27.	Ma J, Wang Z, Cheng T, et al. A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy. CNS Neurosci Ther, 2022, 28(11): 1838-1848.
28.	Geng G, Hu W, Meng Y, et al. Vagus nerve stimulation for treating developmental and epileptic encephalopathy in young children. Front Neurol, 2023, 14: 1191831.
29.	Klinkenberg S, Van Den Bosch CNCJ, Majoie HJM, et al. Behavioural and cognitive effects during vagus nerve stimulation in children with intractable epilepsy – a randomized controlled trial. European Journal of Paediatric Neurology, 2013, 17(1): 82-90.
30.	Morris GL, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
31.	Ostendorf AP, Ng YT. Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat, 2017, 13: 1131-1140.
32.	中国抗癫痫协会创新与转化专委会. Lennox-Gastaut综合征诊断治疗的中国专家共识. 癫痫杂志, 2022, 8(3): 187-195.
33.	Dibué M, Greco T, Spoor JKH, et al. Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: a meta-analysis. Acta Neurol Scand, 2021, 143(5): 497-508.
34.	Cersósimo RO, Bartuluchi M, Fortini S, et al. Vagus nerve stimulation: effectiveness and tolerability in 64 paediatric patients with refractory epilepsies. Epileptic Disorders, 2011, 13(4): 382-388.
35.	Abdelmoity SA, Abdelmoity AA, Riordan SM, et al. The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome. Seizure, 2021, 86: 168-174.
36.	Dravet C. Les epilepsies graves de l’enfant. VIE MED. 1978;59(8): 543-548.
37.	中国抗癫痫协会创新与转化专业委员会 , 中华医学会儿科学分会罕见病学组 , 中华医学会儿科学分会神经学组. Dravet综合征诊断与治疗的中国专家共识. 癫痫杂志, 2024, 10(1): 1-11.
38.	Dibué-Adjei M, Fischer I, Steiger HJ, et al. Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: a meta-analysis of 68 patients. Seizure, 2017, 50: 147-152.
39.	Hajtovic S, LoPresti MA, Zhang L, et al. The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis. Journal of Neurosurgery: Pediatrics, 2022, 29(6): 667-680.
40.	Youn SE, Jung DE, Kang HC, et al. Long-term results of vagus nerve stimulation in children with Dravet syndrome: time-dependent, delayed antiepileptic effect. Epilepsy Res, 2021, 174: 106665.
41.	Zamponi N, Rychlicki F, Corpaci L, et al. Vagus nerve stimulation (VNS) is effective in treating catastrophic 1 epilepsy in very young children. Neurosurg Rev, 2008, 31(3): 291-297.
42.	儿童癫痫持续状态协作组. 儿童癫痫持续状态诊断治疗的中国专家共识(2022). 癫痫杂志, 2022, 8(5): 383-389.
43.	Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain, 2011, 134(Pt 10): 2802-2818.
44.	Arya R, Rotenberg A. Dietary, immunological, surgical, and other emerging treatments for pediatric refractory status epilepticus. Seizure, 2019, 68: 89-96.
45.	Furlanis GM, Favaro J, Bresolin N, et al. Role of vagus nerve stimulation in refractory and super refractory status epilepticus: a pediatric case series. Brain Sciences, 2023, 13(11): 1589.
46.	Stavropoulos I, Pak HL, Alarcon G, et al. Neuromodulation techniques in children with super-refractory status epilepticus. Brain Sci, 2023, 13(11): 1527.
47.	Dibué-Adjei M, Brigo F, Yamamoto T, et al. Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review. Brain Stimul, 2019, 12(5): 1101-1110.
48.	Hamza M, Carron R, Dibué M, et al. Right-sided vagus nerve stimulation for drug-resistant epilepsy: a systematic review of the literature and perspectives. Seizure: European Journal of Epilepsy, 2024, 117: 298-304.
49.	McGregor A, Wheless J, Baumgartner J, et al. Right-sided vagus nerve stimulation as a treatment for refractory epilepsy in humans. Epilepsia, 2005, 46(1): 91-96.
50.	Premchand RK, Sharma K, Mittal S, et al. Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF Trial. Journal of Cardiac Failure, 2014, 20(11): 808-816.
51.	Galbarriatu L, Pomposo I, Aurrecoechea J, et al. Vagus nerve stimulation therapy for treatment-resistant epilepsy: a 15-year experience at a single institution. Clinical Neurology and Neurosurgery, 2015, 137: 89-93.
52.	Navas M, Navarrete EG, Pascual JM, et al. Treatment of refractory epilepsy in adult patients with right-sided vagus nerve stimulation. Epilepsy Research, 2010, 90(1-2): 1-7.
53.	Kahlow H, Olivecrona M. Complications of vagal nerve stimulation for drug-resistant epilepsy. Seizure, 2013, 22(10): 827-833.
54.	Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy & Behavior, 2011, 20(1): 57-63.
55.	Van Schooten J, Smeets J, Van Kuijk SMj, et al. Surgical complications of vagus nerve stimulation surgery: a 14-years single-center experience. Brain and Spine, 2024, 4: 102733.
56.	Muthiah N, Akwayena E, Vodovotz L, et al. Comparison of traditional and closed loop vagus nerve stimulation for treatment of pediatric drug-resistant epilepsy: a propensity-matched retrospective cohort study. Seizure, 2022, 94: 74-81.
57.	Tzadok M, Harush A, Nissenkorn A, et al. Clinical outcomes of closed-loop vagal nerve stimulation in patients with refractory epilepsy. Seizure, 2019, 71: 140-144.
58.	Lo WB, Chevill B, Philip S, et al. Seizure improvement following vagus nerve stimulator (VNS) battery change with cardiac-based seizure detection automatic stimulation (AutoStim): early experience in a regional paediatric unit. Childs Nerv Syst, 2021, 37(4): 1237-1241.
59.	Dugan P, Devinsky O. Guidelines on vagus nerve stimulation for epilepsy. Nat Rev Neurol, 2013, 9(11): 611-612.
60.	Thompson SL, O’Leary GH, Austelle CW, et al. A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders. Front Neurosci, 2021, 15: 709436.
61.	Fahoum F, Boffini M, Kann L, et al. VNS parameters for clinical response in Epilepsy. Brain Stimulation, 2022, 15(3): 814-821.
62.	Koo B, Ham SD, Sood S, et al. Human vagus nerve electrophysiology. J Clin Neurophysiol, 2001, 18(5): 429-433.
63.	Heck C, Helmers SL, DeGiorgio CM. Vagus nerve stimulation therapy, epilepsy, and device parameters: scientific basis and recommendations for use. Neurology, 2002, 59(6 suppl 4): S31-37.
64.	张建国, 张凯, 孟凡刚. 迷走神经刺激术(第一版). 人民卫生出版社, 2019: 42-53.
65.	Helmers SL, Begnaud J, Cowley A, et al. Application of a computational model of vagus nerve stimulation. Acta Neurol Scand, 2012, 126(5): 336-343.
66.	Merrill DR, Bikson M, Jefferys JGR. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. Journal of Neuroscience Methods, 2005, 141(2): 171-198.
67.	DeGiorgio CM, Heck C, Bunch S, et al. Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms. Neurology, 2005, 65(2): 317-319.
68.	DeGiorgio CM, Thompson J, Lewis P, et al. Vagus nerve stimulation: analysis of device parameters in 154 patients during the long-term XE5 study. Epilepsia, 2001, 42(8): 1017-1020.
69.	Kayyali H, Abdelmoity S, Bansal L, et al. The efficacy and safety of rapid cycling vagus nerve stimulation in children with intractable epilepsy. Pediatric Neurology, 2020, 109: 35-38.
70.	韩济生. 神经科学(第四版). 北京大学医学出版社, 2022: 1551-1630.
71.	Xie H, Ji T, Ma J, et al. Remote programming: a convenient and cost-effective measure of vagus nerve stimulation for children with epilepsy. Epilepsy Research, 2020, 159: 106246.
72.	Fisher RS, Eggleston KS, Wright CW. Vagus nerve stimulation magnet activation for seizures: a critical review. Acta Neurol Scand, 2015, 131(1): 1-8.
73.	Majkowska-Zwolińska B, Zwoliński P, Roszkowski M, et al. Long-term results of vagus nerve stimulation in children and adolescents with drug-resistant epilepsy. Childs Nerv Syst, 2012, 28(4): 621-628.
74.	Khurana DS, Reumann M, Hobdell EF, et al. Vagus nerve stimulation in children with refractory epilepsy: unusual complications and relationship to sleep-disordered breathing. Childs Nerv Syst, 2007, 23(11): 1309-1312.
75.	Morris Iii GL. A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy. Epilepsy & Behavior, 2003, 4(6): 740-745.
76.	Touma L, Dansereau B, Chan AY, et al. Neurostimulation in people with drug-resistant epilepsy: systematic review and meta-analysis from the ILAE Surgical Therapies Commission. Epilepsia, 2022, 63(6): 1314-1329.
77.	Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 1998, 51(1): 48-55.
78.	The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology, 1995, 45(2): 224-230.
79.	Levy ML, Levy KM, Hoff D, et al. Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. J Neurosurg Pediatr, 2010, 5(6): 595-602.
80.	Hatano K, Fujimoto A, Yamamoto T, et al. Effects of vagus nerve stimulation following corpus callosotomy for patients with drug-resistant epilepsy. Brain Sciences, 2021, 11(11): 1395.
81.	Roth J, Bergman L, Weil AG, et al. Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: a multicenter, multinational study. Epilepsia, 2023, 64(12): 3205-3212.
82.	Mao H, Chen Y, Ge Q, et al. Short- and long-term response of vagus nerve stimulation therapy in drug-resistant epilepsy: a systematic review and meta-analysis. Neuromodulation: Technology at the Neural Interface, 2022, 25(3): 327-342.
83.	Vonck K, Dedeurwaerdere S, Groote LD, et al. Generator replacement in epilepsy patients treated with vagus nerve stimulation. Seizure, 2005, 14(2): 89-99.
84.	Tatum Iv WO, Ferreira JA, Benbadis SR, et al. Vagus nerve stimulation for pharmacoresistant epilepsy: clinical symptoms with end of service. Epilepsy & Behavior, 2004, 5(1): 128-132.
85.	Chrastina J, Horák O, Ryzí M, et al. Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10–17-year follow-up study. Childs Nerv Syst, 2023, 39(11): 3215-3224.
86.	Labar D, Ponticello L, Nikolov B, et al. Stimulation parameters after vagus nerve stimulator replacement. Neuromodulation: Technology at the Neural Interface, 2008, 11(2): 132-134.
87.	National Institute for Health and Clinical Excellence (NICE). Epilepsies in children, young people and adults. NICE guideline, Published online April 27, 2022. https://www.nice.org.uk/guidance/ng217.
88.	Zhang L, Hall M, Lam SK. Hospital costs associated with vagus nerve stimulation and medical treatment in pediatric patients with refractory epilepsy. Epilepsia, 2022, 63(5): 1141-1151.

1. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia, 1998, 39(7): 677-686.
2. 中国医师协会神经内科分会癫(癎)专委会. 迷走神经刺激术治疗癫(癎)的中国专家共识. 中国医师杂志, 2015, 17(7): 967-968.
3. 中国抗癫痫协会神经调控专业委员会, 中国医师协会神经调控专业委员会, 中华医学会神经外科分会神经生理学组. 迷走神经刺激治疗药物难治性癫痫的中国专家共识. 癫痫杂志, 2021, 7(3): 191-196.
4. McMillan SS, King M, Tully MP. How to use the nominal group and Delphi techniques. Int J Clin Pharm, 2016, 38(3): 655-662.
5. Jain P, Arya R. Vagus nerve stimulation and seizure outcomes in pediatric refractory epilepsy: systematic review and meta-analysis. Neurology, 2021, 96(22): 1041-1051.
6. Orosz I, McCormick D, Zamponi N, et al. Vagus nerve stimulation for drug-resistant epilepsy: a European long-term study up to 24 months in 347 children. Epilepsia, 2014, 55(10): 1576-1584.
7. Feygina AA, Koshelyaevskaya YN, Dibué M, et al. Efficacy and safety following two or more years of vagus nerve stimulation (VNS Therapy) in pediatric patients with drug-resistant epilepsy enrolled in a Russian VNS Registry. Brain & Behavior, 2023, 13(7): e3076.
8. Muthiah N, Zhang J, Remick M, et al. Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy & Behavior, 2020, 112: 107373.
9. Englot DJ, Chang EF, Auguste KI. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response: a review. JNS, 2011, 115(6): 1248-1255.
10. Alexopoulos AV, Kotagal P, Loddenkemper T, et al. Long-term results with vagus nerve stimulation in children with pharmacoresistant epilepsy. Seizure, 2006, 15(7): 491-503.
11. Benifla M, Rutka JT, Logan W, et al. Vagal nerve stimulation for refractory epilepsy in children: indications and experience at the hospital for sick children. Childs Nerv Syst, 2006, 22(8): 1018-1026.
12. Murphy JV, Torkelson R, Dowler I, et al. Vagal nerve stimulation in refractory epilepsy: The first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Arch Pediatr Adolesc Med, 2003, 157(6): 560.
13. Helmers SL, Wheless JW, Frost M, et al. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective Study. J Child Neurol, 2001, 16(11): 843-848.
14. Sauer V, Glaser M, Ellwardt E, et al. Favorable combinations of antiseizure medication with vagus nerve stimulation to improve health-related quality of life in patients with epilepsy. Epilepsy & Behavior, 2024, 150: 109562.
15. Chrastina J, Novák Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: a 10–17 year follow-up study. Seizure, 2018, 59: 41-47.
16. Chrastina J, Kocvarova J, Novak Z, et al. Older age and longer epilepsy duration do not predict worse seizure reduction outcome after vagus nerve stimulation. J Neurol Surg A Cent Eur Neurosurg, 2018, 79(02): 152-158.
17. Hilderink J, Tjepkema-Cloostermans MC, Geertsema A, et al. Predicting success of vagus nerve stimulation (VNS) from EEG symmetry. Seizure, 2017, 48: 69-73.
18. Ching J, Khan S, White P, et al. Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients. British Journal of Neurosurgery, 2013, 27(2): 228-234.
19. Scherrmann J, Hoppe C, Kral T, et al. Vagus nerve stimulation: clinical experience in a large patient series. Journal of Clinical Neurophysiology, 2001, 18(5): 408-414.
20. Amar AP, DeGiorgio CM, Tarver WB, et al. Long-term multicenter experience with vagus nerve stimulation for intractable partial seizures. Stereotact Funct Neurosurg, 1999, 73(1-4): 104-108.
21. Wang HJ, Tan G, Zhu LN, et al. Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy. Seizure, 2019, 66: 53-60.
22. Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery, 2016, 79(3): 345-353.
23. Kostov KH, Kostov H, Larsson PG, et al. Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study. Epilepsia, 2022, 63(2): 414-425.
24. Xie H, Ma J, Ji T, et al. Efficacy of vagus nerve stimulation in 95 children of drug-resistant epilepsy with structural etiology. Epilepsy & Behavior, 2023, 140: 109107.
25. Workewych AM, Arski ON, Mithani K, et al. Biomarkers of seizure response to vagus nerve stimulation: a scoping review. Epilepsia, 2020, 61(10): 2069-2085.
26. Zhang Y, Wang X, Tang C, et al. Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Journal of Neurosurgery, 2022, 136(3): 726-735.
27. Ma J, Wang Z, Cheng T, et al. A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy. CNS Neurosci Ther, 2022, 28(11): 1838-1848.
28. Geng G, Hu W, Meng Y, et al. Vagus nerve stimulation for treating developmental and epileptic encephalopathy in young children. Front Neurol, 2023, 14: 1191831.
29. Klinkenberg S, Van Den Bosch CNCJ, Majoie HJM, et al. Behavioural and cognitive effects during vagus nerve stimulation in children with intractable epilepsy – a randomized controlled trial. European Journal of Paediatric Neurology, 2013, 17(1): 82-90.
30. Morris GL, Gloss D, Buchhalter J, et al. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 2013, 81(16): 1453-1459.
31. Ostendorf AP, Ng YT. Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat, 2017, 13: 1131-1140.
32. 中国抗癫痫协会创新与转化专委会. Lennox-Gastaut综合征诊断治疗的中国专家共识. 癫痫杂志, 2022, 8(3): 187-195.
33. Dibué M, Greco T, Spoor JKH, et al. Vagus nerve stimulation in patients with Lennox-Gastaut syndrome: a meta-analysis. Acta Neurol Scand, 2021, 143(5): 497-508.
34. Cersósimo RO, Bartuluchi M, Fortini S, et al. Vagus nerve stimulation: effectiveness and tolerability in 64 paediatric patients with refractory epilepsies. Epileptic Disorders, 2011, 13(4): 382-388.
35. Abdelmoity SA, Abdelmoity AA, Riordan SM, et al. The efficacy and tolerability of auto-stimulation-VNS in children with Lennox-Gastaut syndrome. Seizure, 2021, 86: 168-174.
36. Dravet C. Les epilepsies graves de l’enfant. VIE MED. 1978;59(8): 543-548.
37. 中国抗癫痫协会创新与转化专业委员会 , 中华医学会儿科学分会罕见病学组 , 中华医学会儿科学分会神经学组. Dravet综合征诊断与治疗的中国专家共识. 癫痫杂志, 2024, 10(1): 1-11.
38. Dibué-Adjei M, Fischer I, Steiger HJ, et al. Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: a meta-analysis of 68 patients. Seizure, 2017, 50: 147-152.
39. Hajtovic S, LoPresti MA, Zhang L, et al. The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis. Journal of Neurosurgery: Pediatrics, 2022, 29(6): 667-680.
40. Youn SE, Jung DE, Kang HC, et al. Long-term results of vagus nerve stimulation in children with Dravet syndrome: time-dependent, delayed antiepileptic effect. Epilepsy Res, 2021, 174: 106665.
41. Zamponi N, Rychlicki F, Corpaci L, et al. Vagus nerve stimulation (VNS) is effective in treating catastrophic 1 epilepsy in very young children. Neurosurg Rev, 2008, 31(3): 291-297.
42. 儿童癫痫持续状态协作组. 儿童癫痫持续状态诊断治疗的中国专家共识(2022). 癫痫杂志, 2022, 8(5): 383-389.
43. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain, 2011, 134(Pt 10): 2802-2818.
44. Arya R, Rotenberg A. Dietary, immunological, surgical, and other emerging treatments for pediatric refractory status epilepticus. Seizure, 2019, 68: 89-96.
45. Furlanis GM, Favaro J, Bresolin N, et al. Role of vagus nerve stimulation in refractory and super refractory status epilepticus: a pediatric case series. Brain Sciences, 2023, 13(11): 1589.
46. Stavropoulos I, Pak HL, Alarcon G, et al. Neuromodulation techniques in children with super-refractory status epilepticus. Brain Sci, 2023, 13(11): 1527.
47. Dibué-Adjei M, Brigo F, Yamamoto T, et al. Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review. Brain Stimul, 2019, 12(5): 1101-1110.
48. Hamza M, Carron R, Dibué M, et al. Right-sided vagus nerve stimulation for drug-resistant epilepsy: a systematic review of the literature and perspectives. Seizure: European Journal of Epilepsy, 2024, 117: 298-304.
49. McGregor A, Wheless J, Baumgartner J, et al. Right-sided vagus nerve stimulation as a treatment for refractory epilepsy in humans. Epilepsia, 2005, 46(1): 91-96.
50. Premchand RK, Sharma K, Mittal S, et al. Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF Trial. Journal of Cardiac Failure, 2014, 20(11): 808-816.
51. Galbarriatu L, Pomposo I, Aurrecoechea J, et al. Vagus nerve stimulation therapy for treatment-resistant epilepsy: a 15-year experience at a single institution. Clinical Neurology and Neurosurgery, 2015, 137: 89-93.
52. Navas M, Navarrete EG, Pascual JM, et al. Treatment of refractory epilepsy in adult patients with right-sided vagus nerve stimulation. Epilepsy Research, 2010, 90(1-2): 1-7.
53. Kahlow H, Olivecrona M. Complications of vagal nerve stimulation for drug-resistant epilepsy. Seizure, 2013, 22(10): 827-833.
54. Elliott RE, Morsi A, Kalhorn SP, et al. Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy & Behavior, 2011, 20(1): 57-63.
55. Van Schooten J, Smeets J, Van Kuijk SMj, et al. Surgical complications of vagus nerve stimulation surgery: a 14-years single-center experience. Brain and Spine, 2024, 4: 102733.
56. Muthiah N, Akwayena E, Vodovotz L, et al. Comparison of traditional and closed loop vagus nerve stimulation for treatment of pediatric drug-resistant epilepsy: a propensity-matched retrospective cohort study. Seizure, 2022, 94: 74-81.
57. Tzadok M, Harush A, Nissenkorn A, et al. Clinical outcomes of closed-loop vagal nerve stimulation in patients with refractory epilepsy. Seizure, 2019, 71: 140-144.
58. Lo WB, Chevill B, Philip S, et al. Seizure improvement following vagus nerve stimulator (VNS) battery change with cardiac-based seizure detection automatic stimulation (AutoStim): early experience in a regional paediatric unit. Childs Nerv Syst, 2021, 37(4): 1237-1241.
59. Dugan P, Devinsky O. Guidelines on vagus nerve stimulation for epilepsy. Nat Rev Neurol, 2013, 9(11): 611-612.
60. Thompson SL, O’Leary GH, Austelle CW, et al. A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders. Front Neurosci, 2021, 15: 709436.
61. Fahoum F, Boffini M, Kann L, et al. VNS parameters for clinical response in Epilepsy. Brain Stimulation, 2022, 15(3): 814-821.
62. Koo B, Ham SD, Sood S, et al. Human vagus nerve electrophysiology. J Clin Neurophysiol, 2001, 18(5): 429-433.
63. Heck C, Helmers SL, DeGiorgio CM. Vagus nerve stimulation therapy, epilepsy, and device parameters: scientific basis and recommendations for use. Neurology, 2002, 59(6 suppl 4): S31-37.
64. 张建国, 张凯, 孟凡刚. 迷走神经刺激术(第一版). 人民卫生出版社, 2019: 42-53.
65. Helmers SL, Begnaud J, Cowley A, et al. Application of a computational model of vagus nerve stimulation. Acta Neurol Scand, 2012, 126(5): 336-343.
66. Merrill DR, Bikson M, Jefferys JGR. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. Journal of Neuroscience Methods, 2005, 141(2): 171-198.
67. DeGiorgio CM, Heck C, Bunch S, et al. Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms. Neurology, 2005, 65(2): 317-319.
68. DeGiorgio CM, Thompson J, Lewis P, et al. Vagus nerve stimulation: analysis of device parameters in 154 patients during the long-term XE5 study. Epilepsia, 2001, 42(8): 1017-1020.
69. Kayyali H, Abdelmoity S, Bansal L, et al. The efficacy and safety of rapid cycling vagus nerve stimulation in children with intractable epilepsy. Pediatric Neurology, 2020, 109: 35-38.
70. 韩济生. 神经科学(第四版). 北京大学医学出版社, 2022: 1551-1630.
71. Xie H, Ji T, Ma J, et al. Remote programming: a convenient and cost-effective measure of vagus nerve stimulation for children with epilepsy. Epilepsy Research, 2020, 159: 106246.
72. Fisher RS, Eggleston KS, Wright CW. Vagus nerve stimulation magnet activation for seizures: a critical review. Acta Neurol Scand, 2015, 131(1): 1-8.
73. Majkowska-Zwolińska B, Zwoliński P, Roszkowski M, et al. Long-term results of vagus nerve stimulation in children and adolescents with drug-resistant epilepsy. Childs Nerv Syst, 2012, 28(4): 621-628.
74. Khurana DS, Reumann M, Hobdell EF, et al. Vagus nerve stimulation in children with refractory epilepsy: unusual complications and relationship to sleep-disordered breathing. Childs Nerv Syst, 2007, 23(11): 1309-1312.
75. Morris Iii GL. A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy. Epilepsy & Behavior, 2003, 4(6): 740-745.
76. Touma L, Dansereau B, Chan AY, et al. Neurostimulation in people with drug-resistant epilepsy: systematic review and meta-analysis from the ILAE Surgical Therapies Commission. Epilepsia, 2022, 63(6): 1314-1329.
77. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 1998, 51(1): 48-55.
78. The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology, 1995, 45(2): 224-230.
79. Levy ML, Levy KM, Hoff D, et al. Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. J Neurosurg Pediatr, 2010, 5(6): 595-602.
80. Hatano K, Fujimoto A, Yamamoto T, et al. Effects of vagus nerve stimulation following corpus callosotomy for patients with drug-resistant epilepsy. Brain Sciences, 2021, 11(11): 1395.
81. Roth J, Bergman L, Weil AG, et al. Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: a multicenter, multinational study. Epilepsia, 2023, 64(12): 3205-3212.
82. Mao H, Chen Y, Ge Q, et al. Short- and long-term response of vagus nerve stimulation therapy in drug-resistant epilepsy: a systematic review and meta-analysis. Neuromodulation: Technology at the Neural Interface, 2022, 25(3): 327-342.
83. Vonck K, Dedeurwaerdere S, Groote LD, et al. Generator replacement in epilepsy patients treated with vagus nerve stimulation. Seizure, 2005, 14(2): 89-99.
84. Tatum Iv WO, Ferreira JA, Benbadis SR, et al. Vagus nerve stimulation for pharmacoresistant epilepsy: clinical symptoms with end of service. Epilepsy & Behavior, 2004, 5(1): 128-132.
85. Chrastina J, Horák O, Ryzí M, et al. Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10–17-year follow-up study. Childs Nerv Syst, 2023, 39(11): 3215-3224.
86. Labar D, Ponticello L, Nikolov B, et al. Stimulation parameters after vagus nerve stimulator replacement. Neuromodulation: Technology at the Neural Interface, 2008, 11(2): 132-134.
87. National Institute for Health and Clinical Excellence (NICE). Epilepsies in children, young people and adults. NICE guideline, Published online April 27, 2022. https://www.nice.org.uk/guidance/ng217.
88. Zhang L, Hall M, Lam SK. Hospital costs associated with vagus nerve stimulation and medical treatment in pediatric patients with refractory epilepsy. Epilepsia, 2022, 63(5): 1141-1151.

Journal of Epilepsy

Latest Articles迷走神经刺激治疗儿童药物难治性癫痫的中国专家共识

Abstract Full text Figures/Tables Video References Cited by

Format

Content