Analysis of electro-clinical characteristics and surgical outcome of low-grade developmental tumors in temporal lobe_Journal of Epilepsy

Authors：

FENG Qian , ZHANG bingqing , WANG Haixiang , BAI Jianjun , LIN Jiuluan , SUN Zhaohui , SHI Jie ,  ZHOU Wenjing

Epilepsy center, Yuquan Hospital, Tsinghua University, Beijing 100049 , China;

Corresponding author：

ZHOU Wenjing, Email: closejeo@hotmail.com

Keywords：

Low-grade developmental tumor; Temporal lobe epilepsy; Ganglioglioma; Dysembryoplastic neuroepithelial tumor

DOI：

10.7507/2096-0247.202412002

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Objective To analyze the electro-clinical characteristics and surgical outcome of low-grade developmental tumors in temporal lobe. Methods The onset age, seizure duration, seizure types, electroencephalogram and surgical outcome of 49 patients with low-grade developmental tumor of temporal lobe were analyzed retrospectively. Results Two groups of the seizure types were divided. The first group was spasm, the other was focal onset. There were 12 cases in spasm group, with an average onset age of (1.00±0.59) years. The discharge was extensive and multi-brain-area locaded, especially in the temporal montages and the ipsilateral posterior montages. There were 37 cases in second group, with an average onset age of (8.90±8.84) years, mainly including autonomic seizure, tonic seizure and automotor seizure. In this group, the discharge was mainly recorded in the temporal montages, which could spread to the frontal montages and less locaded in posterior montages. The difference of onset age between the two groups was statistically significant (P<0.01). The average follow-up of spasm group was (2.80±1.57) years, and the surgical outcome of all patients in this group were all Engel I (100.00%, 12/12). The focal onset group was followed up for an average of (6.50±4.78) years, and the rate of Engel I was 91.80% (34/37). There was no significant difference between the two groups (P>0.05). Conclusions For low-grade developmental tumors in temporal lobe, there are two seizure types, including spasm and focal onset. The onset age of spasm is earlier, while patients with focal onset mostly start at childhood or older, rare in infancy. Surgery has a good effect on the treatment of temporal lobe developmental tumor epilepsy.

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1. Holthausen H, Blümcke I. Epilepsy-associated tumours: what epileptologists should know about neuropathology, terminology, and classification systems. Epileptic Disorders, 2016, 18(3): 240-251.
2. Blümcke I, Aronica E, Becker A, et al. Low-grade epilepsy-associated neuroepithelial tumours — the 2016 WHO classification. Nature Reviews Neurology, 2016, 12(12): 732-740.
3. Isler C, Erturk Cetin O, Ugurlar D, et al. Dysembryoplastic neuroepithelial tumours: clinical, radiological, pathological features and outcome. British Journal of Neurosurgery, 2018, 32(4): 436-441.
4. Slegers RJ, Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020. Acta Neuropathologica Communications, 2020, 8(1): 27.
5. Heiland DH, Staszewski O, Hirsch M, et al. Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis. Journal of Neuropathology & Experimental Neurology, 2016, 75(4): 358-365.
6. Luyken C, Blümcke I, Fimmers R, et al. Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow‐up of 8 years. Cancer, 2004, 101(1): 146-155.
7. Dahiya S, Haydon DH, Alvarado D, et al. BRAFV600E mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathologica, 2013, 125(6): 901-910.
8. Zaky W, Patil SS, Park M, et al. Ganglioglioma in children and young adults: single institution experience and review of the literature. Journal of Neuro-Oncology, 2018, 139(3): 739-747.

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