Factors influencing comorbid sleep disorders in adolescents with epilepsy: a scoping review_Journal of Epilepsy

Authors：

XIA Sijie ^1,2,3,4 , ZHANG Nan ^1,2,3,4 ,  CUI Cui ^1,2,3,4

1. Nursing Department, Children's Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China;
2. National Clinical Research Center for Child Health and Disorders, Chongqing 400014, China;
3. Key Laboratory of Child Development and Disorders, Ministry of Education, Chongqing 400014, China;
4. Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing 400014, China;

Corresponding author：

CUI Cui, Email: cuicui17@126.com

Keywords：

Epilepsy; Adolescents; Sleep disorders; Influencing factors; Scoping review

DOI：

10.7507/2096-0247.202509003

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Objective To conduct a scoping review on the influencing factors of comorbid sleep disorders in adolescents with epilepsy, so as to provide a reference basis for clinical prevention and early intervention. Methods Following the methodological framework of scoping review, relevant studies were systematically searched in PubMed, Web of Science, Cochrane Library, Embase, Chinese Biomedical Literature Database, CNKI, Wanfang, and VIP Database. The retrieval time limit was from the establishment of each database to April 30, 2025. The included literatures were summarized and analyzed. Results A total of 17 literatures were included, and 17 influencing factors related to comorbid sleep disorders in adolescents with epilepsy were identified, which were mainly divided into six categories: demographic factors, characteristics and severity of epilepsy, treatment-related factors, psychiatric comorbidities, organic neurological damage and neurocognitive development and psychosocial and environmental factors. Conclusion Sleep disorders are relatively common in adolescents with epilepsy, and their influencing factors are multifaceted.There is a lack of large-sample research on this population in our country, especially the lack of discussion of the causal relationship between influencing factors and sleep disorders, resulting in a lack of basis for early intervention. Future research urgently needs to systematically identify key influencing factors and explore their internal mechanisms through large-sample surveys, so as to lay a solid scientific foundation for the construction of evidence-based intervention programs.

Citation： XIA Sijie, ZHANG Nan, CUI Cui. Factors influencing comorbid sleep disorders in adolescents with epilepsy: a scoping review. Journal of Epilepsy, 2025, 11(6): 508-514. doi: 10.7507/2096-0247.202509003 Copy

1.	路蝉伊, 刘立雄, 张云峰. 癫痫发病机制的研究进展. 解放军医学院学报, 2014, 35(8): 876-881.
2.	Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394.
3.	朱登纳, 牛国辉. 儿童癫痫的长程管理. 临床儿科杂志, 2023, 41(3): 235-240.
4.	黄路遥, 丁晶, 汪昕. 癫痫与睡眠障碍共病的研究进展. 中国临床医学, 2025, 32(3): 505-511.
5.	胡盼, 肖争. 癫痫共病失眠的研究进展. 癫痫与神经电生理学杂志, 2024, 33(4): 237-242.
6.	麦子峰, 许鸿燕, 马宁. 急性睡眠剥夺对认知与情绪功能的影响及其神经机制的研究进展. 中国全科医学, 2021, 24(29): 3653-3659.
7.	Craig L, Kelli Borgess DS, Robin P. Practical guidance for knowledge synthesis: scoping review methods. Asian Nurs Res (Korean Soc Nurs Sci), 2019, 13(5): 287-294.
8.	Proost R, Cleeren E, Jansen B, et al. Factors associated with poor sleep in children with drug-resistant epilepsy. Epilepsia, 2024, 65(11): 3335-3349.
9.	Byars A, Byars K, Johnson C, et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy behav, 2008, 13(4): 607-613.
10.	Ekinci O, Isik U, Gunes S, et al. Understanding sleep problems in children with epilepsy: associations with quality of life, attention-deficit hyperactivity disorder and maternal emotional symptoms. Seizure, 2016, 40: 108-113.
11.	Ong L, Yang W, Wong S, et al. Sleep habits and disturbances in Malaysian children with epilepsy. J paediatr child health, 2010, 46(3): 80-84.
12.	Düken M, Zengin M. The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy. Epilepsy behav, 2024, 152: 109656.
13.	Neto F, Nunes M. Evaluation of sleep organization in patients with attention deficit hyperactivity disorder (ADHD) and ADHD as a comorbidity of epilepsy. Sleep med, 2017, 33: 91-96.
14.	Hansen B, Alfstad K, van Roy B, et al. Sleep problems in children and adolescents with epilepsy: Associations with psychiatric comorbidity. Epilepsy behav, 2016, 62: 14-19.
15.	张萌萌, 周农. 学龄期癫痫儿童睡眠问题及其影响因素分析. 安徽医科大学学报, 2017, 52(4): 579-584.
16.	蔡晓唐, 罗蓉, 康琳敏, 等. 7~14岁癫痫患儿睡眠习惯调查及分析. 中国实用儿科杂志, 2010, 25(11): 868-870.
17.	郭柳, 金春华, 杨淑霞, 等. 癫痫患儿睡眠质量问卷调查. 世界睡眠医学杂志, 2014(1): 39-41.
18.	毛云青, 董恩恒, 李多多, 等. 伴中央颞区棘波自限性癫痫患儿睡眠状况及影响因素分析. 新乡医学院学报, 2024, 41(4): 348-352.
19.	杨晓辉, 董耀荣. 抗痫治疗对睡眠相关性癫痫患儿睡眠结构的影响作用. 贵州医药, 2016, 40(1): 45-47.
20.	邓瑶, 周洁兰, 喻韬. 440例癫痫儿童睡眠问题及其影响因素分析. 现代临床医学, 2021, 47(6): 401-403,418.
21.	黄娟, 万方锐. 丙戊酸钠对伴中央颞区棘波的儿童良性癫痫睡眠结构的影响. 江西医药, 2016, 51(10): 1090-1091.
22.	黎西, 周农. 临床下发作的原发性癫痫儿童睡眠结构特点及其影响因素. 安徽医科大学学报, 2012, 47(2): 164-166.
23.	刘文超, 张开慧, 徐小莲, 等. 青少年癫痫共病焦虑抑郁患者的睡眠特点研究及相关性分析. 癫痫与神经电生理学杂志, 2025, 34(1): 27-32.
24.	曾锦英. 儿童良性癫痫发作间期癫痫样放电对睡眠结构的影响. 实用心脑肺血管病杂志, 2014, 22(4): 114-115.
25.	Sivertsen B, Harvey A, Pallesen S, et al. Trajectories of sleep problems from childhood to adolescence: a population-based longitudinal study from Norway. J Sleep Res, 2017, 26(1): 55-63.
26.	Hadjimarkou M, Benham R, Schwarz J, et al. Estradiol suppresses rapid eye movement sleep and activation of sleep-active neurons in the ventrolateral preoptic area. Eur J Neurosci, 2008, 27(7): 1780-1792.
27.	Paul K, Laposky A, Turek F. Reproductive hormone replacement alters sleep in mice. Neurosci Lett, 2009, 463(3): 239-243.
28.	Perucca E, Perucca P, White H, et al. Drug resistance in epilepsy. Lancet Neurol, 2023, 22(8): 723-734.
29.	Lee S, Choi E, Jeon J, et al. Insomnia moderates the association between recurrent seizures and emotional instability in persons with epilepsy. Epilepsy behav, 2021, 125: 108414.
30.	Atrooz F, Liu H, Kochi C, et al. Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes. Neuroscience, 2019, 406: 22-37.
31.	王辉. 拉莫三嗪联合丙戊酸钠对儿童福利院内儿童癫痫发作控制情况、发作频率、睡眠质量的影响分析. 医药卫生, 2025(4): 48-51.
32.	王敏涵, 李琦, 黄晓琼, 等. 工娱疗法对青少年癫痫病人自尊水平及生活质量的影响. 全科护理, 2023, 21(30): 4254-4257.
33.	陈丽花. 心理康复护理对癫痫儿童睡眠及家长心理状况的改善效果. 黑龙江中医药, 2022, 51(5): 146-147.
34.	池海珊. 健康教育干预对小儿癫痫患儿睡眠质量的效果研究. 世界睡眠医学杂志, 2024, 11(10): 2235-2237,2241.

1. 路蝉伊, 刘立雄, 张云峰. 癫痫发病机制的研究进展. 解放军医学院学报, 2014, 35(8): 876-881.
2. Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394.
3. 朱登纳, 牛国辉. 儿童癫痫的长程管理. 临床儿科杂志, 2023, 41(3): 235-240.
4. 黄路遥, 丁晶, 汪昕. 癫痫与睡眠障碍共病的研究进展. 中国临床医学, 2025, 32(3): 505-511.
5. 胡盼, 肖争. 癫痫共病失眠的研究进展. 癫痫与神经电生理学杂志, 2024, 33(4): 237-242.
6. 麦子峰, 许鸿燕, 马宁. 急性睡眠剥夺对认知与情绪功能的影响及其神经机制的研究进展. 中国全科医学, 2021, 24(29): 3653-3659.
7. Craig L, Kelli Borgess DS, Robin P. Practical guidance for knowledge synthesis: scoping review methods. Asian Nurs Res (Korean Soc Nurs Sci), 2019, 13(5): 287-294.
8. Proost R, Cleeren E, Jansen B, et al. Factors associated with poor sleep in children with drug-resistant epilepsy. Epilepsia, 2024, 65(11): 3335-3349.
9. Byars A, Byars K, Johnson C, et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy behav, 2008, 13(4): 607-613.
10. Ekinci O, Isik U, Gunes S, et al. Understanding sleep problems in children with epilepsy: associations with quality of life, attention-deficit hyperactivity disorder and maternal emotional symptoms. Seizure, 2016, 40: 108-113.
11. Ong L, Yang W, Wong S, et al. Sleep habits and disturbances in Malaysian children with epilepsy. J paediatr child health, 2010, 46(3): 80-84.
12. Düken M, Zengin M. The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy. Epilepsy behav, 2024, 152: 109656.
13. Neto F, Nunes M. Evaluation of sleep organization in patients with attention deficit hyperactivity disorder (ADHD) and ADHD as a comorbidity of epilepsy. Sleep med, 2017, 33: 91-96.
14. Hansen B, Alfstad K, van Roy B, et al. Sleep problems in children and adolescents with epilepsy: Associations with psychiatric comorbidity. Epilepsy behav, 2016, 62: 14-19.
15. 张萌萌, 周农. 学龄期癫痫儿童睡眠问题及其影响因素分析. 安徽医科大学学报, 2017, 52(4): 579-584.
16. 蔡晓唐, 罗蓉, 康琳敏, 等. 7~14岁癫痫患儿睡眠习惯调查及分析. 中国实用儿科杂志, 2010, 25(11): 868-870.
17. 郭柳, 金春华, 杨淑霞, 等. 癫痫患儿睡眠质量问卷调查. 世界睡眠医学杂志, 2014(1): 39-41.
18. 毛云青, 董恩恒, 李多多, 等. 伴中央颞区棘波自限性癫痫患儿睡眠状况及影响因素分析. 新乡医学院学报, 2024, 41(4): 348-352.
19. 杨晓辉, 董耀荣. 抗痫治疗对睡眠相关性癫痫患儿睡眠结构的影响作用. 贵州医药, 2016, 40(1): 45-47.
20. 邓瑶, 周洁兰, 喻韬. 440例癫痫儿童睡眠问题及其影响因素分析. 现代临床医学, 2021, 47(6): 401-403,418.
21. 黄娟, 万方锐. 丙戊酸钠对伴中央颞区棘波的儿童良性癫痫睡眠结构的影响. 江西医药, 2016, 51(10): 1090-1091.
22. 黎西, 周农. 临床下发作的原发性癫痫儿童睡眠结构特点及其影响因素. 安徽医科大学学报, 2012, 47(2): 164-166.
23. 刘文超, 张开慧, 徐小莲, 等. 青少年癫痫共病焦虑抑郁患者的睡眠特点研究及相关性分析. 癫痫与神经电生理学杂志, 2025, 34(1): 27-32.
24. 曾锦英. 儿童良性癫痫发作间期癫痫样放电对睡眠结构的影响. 实用心脑肺血管病杂志, 2014, 22(4): 114-115.
25. Sivertsen B, Harvey A, Pallesen S, et al. Trajectories of sleep problems from childhood to adolescence: a population-based longitudinal study from Norway. J Sleep Res, 2017, 26(1): 55-63.
26. Hadjimarkou M, Benham R, Schwarz J, et al. Estradiol suppresses rapid eye movement sleep and activation of sleep-active neurons in the ventrolateral preoptic area. Eur J Neurosci, 2008, 27(7): 1780-1792.
27. Paul K, Laposky A, Turek F. Reproductive hormone replacement alters sleep in mice. Neurosci Lett, 2009, 463(3): 239-243.
28. Perucca E, Perucca P, White H, et al. Drug resistance in epilepsy. Lancet Neurol, 2023, 22(8): 723-734.
29. Lee S, Choi E, Jeon J, et al. Insomnia moderates the association between recurrent seizures and emotional instability in persons with epilepsy. Epilepsy behav, 2021, 125: 108414.
30. Atrooz F, Liu H, Kochi C, et al. Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes. Neuroscience, 2019, 406: 22-37.
31. 王辉. 拉莫三嗪联合丙戊酸钠对儿童福利院内儿童癫痫发作控制情况、发作频率、睡眠质量的影响分析. 医药卫生, 2025(4): 48-51.
32. 王敏涵, 李琦, 黄晓琼, 等. 工娱疗法对青少年癫痫病人自尊水平及生活质量的影响. 全科护理, 2023, 21(30): 4254-4257.
33. 陈丽花. 心理康复护理对癫痫儿童睡眠及家长心理状况的改善效果. 黑龙江中医药, 2022, 51(5): 146-147.
34. 池海珊. 健康教育干预对小儿癫痫患儿睡眠质量的效果研究. 世界睡眠医学杂志, 2024, 11(10): 2235-2237,2241.

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