以非惊厥性癫痫持续状态为首发表现的FLAMES综合征一例_Journal of Epilepsy

Authors：

周辉 ^1,2,3 , 马小丹 ^1,3,4 , 罗媛媛 ^1,3 , 黄宏燕 ^1,3 ,  郝晓婷 ^1,3

1. ;
2. ;
3. ;
4. ;

Corresponding author：

郝晓婷, Email: sherryhao@wchscu.cn

Keywords：

非惊厥性癫痫持续状态; 髓鞘少突胶质细胞糖蛋白; 癫痫

DOI：

10.7507/2096-0247.202509011

Video：

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Citation： 周辉, 马小丹, 罗媛媛, 黄宏燕, 郝晓婷. 以非惊厥性癫痫持续状态为首发表现的FLAMES综合征一例. Journal of Epilepsy, 2025, 11(6): 519-523. doi: 10.7507/2096-0247.202509011 Copy

1.	Ramanathan S, Dale R, Brilot F. Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun rev, 2016, 15(4): 307-324.
2.	Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J neuroinflamm, 2018, 15(1): 134.
3.	Vega E, Arrambide G, Olivé G, et al. Non-ADEM encephalitis in patients with myelin oligodendrocyte glycoprotein antibodies: a systematic review. Eur J neurol, 2023, 30(5): 1515-1527.
4.	Takegami N, Murai H, Mori H, et al. Multiple cortical lesions with grainy enhancement of magnetic resonance imaging in anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis with seizures (FLAMES). J neurol sci, 2023, 451: 120729.
5.	Ogawa R, Nakashima I, Takahashi T, et al. MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy. Neurol-neuroimmunol neuroinflammation, 2017, 4(2): 322.
6.	Budhram A, Mirian A, Sharma M. Meningo-cortical manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease: Review of a novel clinico-radiographic spectrum. Front neurol, 2022, 13: 1044642.
7.	李波, 王展航. 抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病(MOGAD)的诊断. 中国神经免疫学和神经病学杂志, 2025, 32(2): 89-94.
8.	刘康, 王薇, 靳梅, 等. 以癫痫发作为首发症状的MOG抗体相关疾病患者临床分析. 中国神经免疫学和神经病学杂志, 2022, 29(5): 386-392.
9.	李尚茹, 常旭婷, 张捷, 等. 儿童MOGAD中急性症状性癫痫发作及继发癫痫的相关因素分析. 中华儿科杂志, 2024, 62(7): 655-660.
10.	张敏, 马煦, 杨春晓, 等. 成人非惊厥性癫痫持续状态患者的临床及脑电图特征. 中国医药导报, 2018, 15(2): 62-66.
11.	杨丹, 王向波, 闫鶴立, 等. 髓鞘少突胶质细胞糖蛋白抗体相关疾病临床及影像分析. 中国神经精神疾病杂志, 2023, 49(6): 331-339.
12.	戴雨薇, 尹晴, 杨利. 癫痫的自身免疫性病因研究进展概述. 中华神经科杂志, 2024, 57(5): 511-518.
13.	Liu K, Wang W, Jin M, et al. FLAIR hyperintense cortical lesions in myelin oligodendrocyte glycoprotein-associated encephalitis with seizures in children: a retrospective single-center case series. Front immunol, 2025, 16: 1563481.
14.	Misu T. Myelin oligodendrocyte glycoprotein antibody-associated disease: pathophysiology, clinical patterns, and therapeutic challenges of intractable and severe forms. Int J mol sci, 2025, 26(17): 8538.
15.	尹翮翔, 张遥, 徐雁, 等. MOG抗体相关脑炎临床特点与预后分析. 中国神经免疫学和神经病学杂志, 2021, 28(4): 288-292, 322.

1. Ramanathan S, Dale R, Brilot F. Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun rev, 2016, 15(4): 307-324.
2. Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J neuroinflamm, 2018, 15(1): 134.
3. Vega E, Arrambide G, Olivé G, et al. Non-ADEM encephalitis in patients with myelin oligodendrocyte glycoprotein antibodies: a systematic review. Eur J neurol, 2023, 30(5): 1515-1527.
4. Takegami N, Murai H, Mori H, et al. Multiple cortical lesions with grainy enhancement of magnetic resonance imaging in anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis with seizures (FLAMES). J neurol sci, 2023, 451: 120729.
5. Ogawa R, Nakashima I, Takahashi T, et al. MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy. Neurol-neuroimmunol neuroinflammation, 2017, 4(2): 322.
6. Budhram A, Mirian A, Sharma M. Meningo-cortical manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease: Review of a novel clinico-radiographic spectrum. Front neurol, 2022, 13: 1044642.
7. 李波, 王展航. 抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病(MOGAD)的诊断. 中国神经免疫学和神经病学杂志, 2025, 32(2): 89-94.
8. 刘康, 王薇, 靳梅, 等. 以癫痫发作为首发症状的MOG抗体相关疾病患者临床分析. 中国神经免疫学和神经病学杂志, 2022, 29(5): 386-392.
9. 李尚茹, 常旭婷, 张捷, 等. 儿童MOGAD中急性症状性癫痫发作及继发癫痫的相关因素分析. 中华儿科杂志, 2024, 62(7): 655-660.
10. 张敏, 马煦, 杨春晓, 等. 成人非惊厥性癫痫持续状态患者的临床及脑电图特征. 中国医药导报, 2018, 15(2): 62-66.
11. 杨丹, 王向波, 闫鶴立, 等. 髓鞘少突胶质细胞糖蛋白抗体相关疾病临床及影像分析. 中国神经精神疾病杂志, 2023, 49(6): 331-339.
12. 戴雨薇, 尹晴, 杨利. 癫痫的自身免疫性病因研究进展概述. 中华神经科杂志, 2024, 57(5): 511-518.
13. Liu K, Wang W, Jin M, et al. FLAIR hyperintense cortical lesions in myelin oligodendrocyte glycoprotein-associated encephalitis with seizures in children: a retrospective single-center case series. Front immunol, 2025, 16: 1563481.
14. Misu T. Myelin oligodendrocyte glycoprotein antibody-associated disease: pathophysiology, clinical patterns, and therapeutic challenges of intractable and severe forms. Int J mol sci, 2025, 26(17): 8538.
15. 尹翮翔, 张遥, 徐雁, 等. MOG抗体相关脑炎临床特点与预后分析. 中国神经免疫学和神经病学杂志, 2021, 28(4): 288-292, 322.

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以非惊厥性癫痫持续状态为首发表现的FLAMES综合征一例

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