Evaluation of Glucosamine Hydrochloride Combined with Celecoxib in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

TANG Yilun ,  WANG Kunzheng , DANG Xiaoqian , SONG Jinhui , SHI Zhibin

Department 1 of Orthopedics, the 2nd Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, P. R. China;

Corresponding author：

WANG Kunzheng, Email: a_lun1111@163.com

Keywords：

骨关节炎，膝; 盐酸氨基葡萄糖; 塞来昔布

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　观察评价盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎（KOA）的疗效及安全性。方法　2001年3月－2012年3月采用随机对照方法，将184例KOA患者随机分为对照组与试验组，各92例。对照组单独给予塞来昔布，试验组给予塞来昔布和盐酸氨基葡萄糖，共治疗8周，停药后继续观察4周。采用Lequesne指数作为疗效评分标准，观察服药前后的膝关节症状变化，包括休息痛、运动痛、压痛、肿胀、晨僵和行走能力的改善程度，纪录不良反应及实验室生化指标等。结果　两组Lequesne指数在治疗前相比均明显下降，两组治疗8周后Lequesne总指数比较差异均有统计学意义（P＜0.05）。治疗8周后试验组总有效率明显优于对照组。安全性方面两组比较无差异。结论　盐酸氨基葡萄糖结合塞来昔布治疗KOA，能明显改善患者的临床症状，疗效优于单纯的塞来昔布治疗，且不会增加药物不良反应，具有较好的临床价值。

Citation： TANG Yilun,WANG Kunzheng,DANG Xiaoqian,SONG Jinhui,SHI Zhibin. Evaluation of Glucosamine Hydrochloride Combined with Celecoxib in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2012, 27(12): 1780-1783. doi: Copy

1.	Xu L, Nevitt MC, Zhang Y, et al. High prevalence of knee, but not hip or hand ostetarthritis in Beijing elders:comprision with data of Caucasian in United States[J]. Nat Med J China, 2003, 83(14): l206-l209.
2.	Felson DT. Clinical practice--osteoarthritis of the knee[J]. N Engl J Med, 2006, 354(8): 841-848.
3.	Lanas A, Tornero J, Zamorano JL. Asessment of gastrointestinal and cardiaovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study[J]. Ann Rheum Dis, 2010, 69(8): 1453-1458.
4.	Oegema TR Jr, Deloria LB, Sandy JD, et al. Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits[J]. Arthritis Rheum, 2002, 46(9): 2495-2503.
5.	Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro[J]. Osteoarthritis Cartilage, 1998, 6(6): 427-434.
6.	Fenton JI, Chlebek-Brown KA, Peters TL, et al. Glucosamine HCl reduces equine articular cartilage degradation in explant culture[J]. Osteoarthritis Cartilage, 2000, 8(4): 258-265.
7.	Brief AA, Maurer SG, Di Cesare PE. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis[J]. J Am Acad Orthop Surg, 2001, 9(2): 71-78.
8.	Barr S, Bellamy N, Buchanan WW, et al. A comparative study of signal versus aggregate methods of outcome measurement based on the WOMAC Osteoarthritis Index. Western Ontario and McMaster Universities Osteoarthritis Index[J]. J Rheumatol, 1994, 21(11): 2106-2112.
9.	Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee[J]. Arthritis Rheum, 1986, 29(8): l049-1039.
10.	Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol, 1991, 27: 16-18.
11.	Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8): 1343-1355.
12.	Wieland HA, Michaelis M, Kirschbaum BJ, et al. Osteoarthritis - an untreatable disease?[J]. Nat Rev Drug Discov, 2005, 4(4): 331-344.
13.	Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50): 4405-4409.
14.	Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
15.	Mcalindon TE, Lavalley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis[J]. JAMA, 2000, 283(11): 1469-1475.

1. 　Xu L, Nevitt MC, Zhang Y, et al. High prevalence of knee, but not hip or hand ostetarthritis in Beijing elders:comprision with data of Caucasian in United States[J]. Nat Med J China, 2003, 83(14): l206-l209.
2. 　Felson DT. Clinical practice--osteoarthritis of the knee[J]. N Engl J Med, 2006, 354(8): 841-848.
3. 　Lanas A, Tornero J, Zamorano JL. Asessment of gastrointestinal and cardiaovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study[J]. Ann Rheum Dis, 2010, 69(8): 1453-1458.
4. 　Oegema TR Jr, Deloria LB, Sandy JD, et al. Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits[J]. Arthritis Rheum, 2002, 46(9): 2495-2503.
5. 　Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro[J]. Osteoarthritis Cartilage, 1998, 6(6): 427-434.
6. 　Fenton JI, Chlebek-Brown KA, Peters TL, et al. Glucosamine HCl reduces equine articular cartilage degradation in explant culture[J]. Osteoarthritis Cartilage, 2000, 8(4): 258-265.
7. 　Brief AA, Maurer SG, Di Cesare PE. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis[J]. J Am Acad Orthop Surg, 2001, 9(2): 71-78.
8. 　Barr S, Bellamy N, Buchanan WW, et al. A comparative study of signal versus aggregate methods of outcome measurement based on the WOMAC Osteoarthritis Index. Western Ontario and McMaster Universities Osteoarthritis Index[J]. J Rheumatol, 1994, 21(11): 2106-2112.
9. 　Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee[J]. Arthritis Rheum, 1986, 29(8): l049-1039.
10. 　Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol, 1991, 27: 16-18.
11. 　Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8): 1343-1355.
12. 　Wieland HA, Michaelis M, Kirschbaum BJ, et al. Osteoarthritis - an untreatable disease?[J]. Nat Rev Drug Discov, 2005, 4(4): 331-344.
13. 　Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50): 4405-4409.
14. 　Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
15. 　Mcalindon TE, Lavalley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis[J]. JAMA, 2000, 283(11): 1469-1475.

West China Medical Journal

Evaluation of Glucosamine Hydrochloride Combined with Celecoxib in the Treatment of Knee Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Format

Content