Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis_West China Medical Journal

Authors：

DING Yuhui ¹ ,  LI Sen ²

1. Department of Anesthesiology; 2. Department of Spine Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LI Sen, Email: dingyuhui1@126.com

Keywords：

盐酸氨基葡萄糖; 骨关节炎，腰椎小关节; 临床疗效

Video：

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目的　观察盐酸氨基葡萄糖治疗腰椎小关节骨关节炎的临床疗效。方法　 2010年9月－2012年5月门诊就诊的160例腰椎小关节骨关节炎患者随机分为两组进行治疗，对照组80例，口服非甾体抗炎药物尼美舒利；试验组80例，在服用尼美舒利的基础上加服盐酸氨基葡萄糖，治疗周期为2周。对两组患者治疗前及治疗后1、2周后日常生活能力、视觉疼痛模拟、心理测评（采用症状自评量表检测）3项指标进行检测，比较两组的临床疗效，并对患者进行3个月随访。结果　两组患者各指标检测结果显示，治疗后较治疗前均明显改善，试验组明显优于对照组；总有效率试验组为97.3%，对照组为86.1%，试验组明显优于对照组，组间比较差异有统计学意义（P＜0.05）。结论　盐酸氨基葡萄糖联合尼美舒利治疗腰椎小关节骨关节炎具有较好的临床疗效。

Citation： DING Yuhui,LI Sen. Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis. West China Medical Journal, 2012, 27(12): 1814-1817. doi: Copy

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1. 　Manchikanti L, Hirsch JA, Pampati V. Chronic low back pain of facet (zygapophysial) joint origin:is there a difference based on involvement of single or multiple spinal regions?[J]. Pain Physician, 2003, 6(4): 399-405.
2. 　ManchikantiL, Singhv PV. Is there correlation of facejoint pain in lumbar and cervical spine[J]. Pain Physician, 2002, 4(5): 365-371.
3. 　饶书城, 宋跃明. 脊柱外科手术学[M]. 3版. 北京: 人民卫生出版社, 2006: 510-515.
4. 　王家良. 临床流行病学-临床科研设计, 衡量与评价[M]. 2版. 上海: 上海科学技术出版社, 2001: 47-59.
5. 　刘云鹏, 刘沂. 骨与关节损伤和疾病的诊断分类及功能评定标准[M]. 北京: 清华大学出版社, 2002: 246.
6. 　Sato H, kikuchi S. The natural history of radiographic instability of the lumber spine[J]. Spine (Phila Pa 1976), 1993, 18(14): 2075-2079.
7. 　王开明, 刘运敏, 潘开昌, 等. 腰椎小关节穿刺的应用解剖[J]. 中国临床解剖学杂志, 2007, 25(4): 397-399.
8. 　Borenstein D. Does osteoarthritis of the lumbar spine cause chroniclow back pain?[J]. Curr Pain Headache Rep, 2004, 8(6): 512-517.
9. 　Gorbach C, Schmid MR, Elfering A, et al. Therapeutic efficacy of facet joint blocks[J]. AJR Am J Roentgenol, 2006, 186(5): 1228-1233.
10. 　Sehgal N, Shah RV, Mckenzie-Brown A, et al. Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence[J]. Pain Physician, 2005, 8(2): 211-224.
11. 　李晓宏, 赵伟成, 杨承祥. 奥泰灵用于治疗膝骨关节炎的临床观察[J]. 中国疼痛医学杂志, 2005, 11(6): 365-366.
12. 　Gatti JC. Glucosamine treatment for osteoarthritis[J]. Am Fam Physician, 2006, 73(7): 1189-1191.
13. 　Fox BA, Schmitz ED, Wallace R. FPIN’s clinical inquiries. Glucosamine and chondroitin for osteoarthritis[J]. Am Fam Physician, 2006, 73(7): 1245-1246.
14. 　陈德生, 张志刚, 曹靖, 等. 盐酸氨基葡萄糖对兔膝骨性关节炎的影响[J]. 中国修复重建外科杂志, 2010, 24(3): 287-291.
15. 　江相保, 高李侠. 盐酸氨基葡萄糖治疗膝退行性骨关节炎的临床观察[J]. 中国修复重建外科杂志, 2008, 22(1): 29-31.

West China Medical Journal

Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis

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