目的:研究银杏达莫对糖尿病大鼠肾功能的影响,并从抗氧化应激反应的角度探讨其可能的作用机制。方法:50只Wistar大鼠随机分为正常组(10只),糖尿病模型组(20只)及糖尿病模型加银杏达莫组(20只)。采用单次腹腔注射链脲佐菌素(55 mg/kg)诱导糖尿病肾病(DN)大鼠模型,腹腔注射银杏达莫水溶液。生化法测定血糖,血、尿肌酐及尿白蛋白;尾静脉取血ELISA法检测血清血管内皮先长因子(VEGF)水平;肾脏匀浆后测肾脏丙二醛(MDA)、一氧化氮(NO)的含量。结果:糖尿病模型组和银杏达莫组生化指标均高于正常组(P lt;0.05),银杏达莫组MDA、NO及VEGF的表达减少与模型组比较差异有显著性(P lt;0.05)。结论:银杏达莫具有减轻糖尿病大鼠蛋白尿,提高尿肌酐排泄,减轻肾脏损害的作用,其机制可能与提高肾脏抗氧化系统功能有关。
Citation:
YANG Tingqiang,ZHANG Yan,SHEN Chengyi. Peritoneal Ginkgo-dipyidamolum on Renal Function and Antioxidative Effect in Diabetic Rats. West China Medical Journal, 2009, 24(1): 132-134. doi:
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Koga K,Yamagishi S,Takeuchi M,et al.CS886,a new angiotensin Ⅱ type Ⅰ receptor antagonist,ameliorates glomerular anionic site loss and prevents progression of diabetic nephropathy in Otsuka LongEvans Tokushina fatty rats[J].Mol Med,2002,8(10):591-599.[7]Zeng L,Xu H,Chew TL,et al.HMG CoA reductase inhibition modulates VEGFinduced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation[J].FASEB J,2005,19(13):1845-1847.
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- 1. Koga K,Yamagishi S,Takeuchi M,et al.CS886,a new angiotensin Ⅱ type Ⅰ receptor antagonist,ameliorates glomerular anionic site loss and prevents progression of diabetic nephropathy in Otsuka LongEvans Tokushina fatty rats[J].Mol Med,2002,8(10):591-599.[7]Zeng L,Xu H,Chew TL,et al.HMG CoA reductase inhibition modulates VEGFinduced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation[J].FASEB J,2005,19(13):1845-1847.