Inflammatoin，Malnutrition and Lipid metabolism in Maintenance Hemodialysis Patients_West China Medical Journal

Authors：

Department of Nephrology,West China Hospital,Sichuan University,Chengdu 610041，China;

Corresponding author：

Keywords：

血液透析; 脂质代谢; 炎症; 营养不良; 心血管疾病

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的：探讨尿毒症维持性血透(MHD)患者营养不良、炎症与脂质代谢紊乱三者间的相关关系，以及对心血管并发症的预测。方法:测51例尿毒症维持性血透患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白(Apo)A1、ApoB、脂蛋白（a）LP(a)、白蛋白(ALB)、C反应蛋白(CRP)、血清铁蛋白（SF），与30例正常人进行对照研究。结果：MHD患者TG、LDL、ApoB、LP(a)、CRP、SF显著增高,HDL、ApoA1、ALB显著降低(P＜0.05)；随着透析时间的延长，各项检测指标变化进一步加重；且心血管事件发生者血清CRP和LP(a)明显增高，ALB明显降低，血脂紊乱更显著。相关性分析：ALB与HDL、ApoA1正相关，与CRP、LP(a)、TC、TG、ApoB负相关；CRP与LP(a)、TC、TG、ApoB、LDL、SF正相关，与HDL、ApoA1负相关，P均＜0.05。结论：MHD患者存在明显的脂质代谢紊乱、炎症和营养不良，三者的相互促进和影响可能是心血管事件发生的危险因素。

Citation： ZUO Chuan,XIE Xisheng,LI Zi,et al.. Inflammatoin，Malnutrition and Lipid metabolism in Maintenance Hemodialysis Patients. West China Medical Journal, 2008, 23(1): 48-50. doi: Copy

1.	Himmelfarb J.Relevance of oxidative pathways in the pathophysiology of chronic kidney disease[J].Cardiol Clin,2005,23(3):319-330.
2.	王海燕.肾脏病学[M].北京:人民卫生出版社，1996:597.
3.	Stenvinkel P,Heimburger O,Paultre F,et al.Strong association between malnutrition，inflammation，and atherosclerosis in chronic renal failure[J].KidneyInt，1999，55（5）：1899-1911.
4.	Menon V，Wang X，Greene T，et al.Relationship between C-reactive protein，albumin，and cardiovascular disease in patients with chronic kidney disease[J].Am J Kidney Dis，2003，42（1）：44-52.
5.	Prieto D,Benedito S,Simonsen U,et al.Regional heterogeneity in the contractile and potentiating effects of neuropeptide Y in rat isolated coronary arteries:Modulatory action of endothelium[J].Br J Pharmacol,1991,102(3):754-758.
6.	Kalantar ZK,Stenvinkel P,Bross R,et al.Kidney insufficiency and nutrient-based modulation of imflammation[J].Curr Opin Clin NutrMetab Care,2005,8(4):388-396.
7.	Efendic E,Lindholm B,Bergstrom J,et al.Strong connection between malnutrition,inflammation and arteriosclerosis.Improved treatment of renal failure if underlying factors are attacked[J].Lakartidningen,1999,96(42):4538-4542.
8.	Bergstrom J,Lindholm B.Malnutrition,cardiac disease,and mortality:an integrated point of view[J].Am J Kidney Dis,1998,32(5):834-841.
9.	Tetta C,Biasioli S,Schiavon R,et al.An overview of haemodialysis and oxidant stress[J].Blood Purif,1999,17:118－126.
10.	Morena M,Cristol JP,Canaud B,et al.Why hemodialysis patients are in a prooxidant state?What could be done to correct the pro/antioxidant imbalance[J].Blood Purif,2000,18(3):191-199.
11.	Wratten ML,Navino C,Tetta C,et al.Haemolipodialysis[J].Blood Purif,1999,17:127-133.
12.	Danielski M，Ikizler TA，McMonagle E，et al.Linkage of hypoalbuminemia，inflammation，and oxidative stress in patients receiving maintenance hemodialysis therapy[J].Am J Kidney Dis,2003,42:286-294.Morewr M,CristalJP,Canaud B.Blood Psuif,2000,18:191-199.

1. Himmelfarb J.Relevance of oxidative pathways in the pathophysiology of chronic kidney disease[J].Cardiol Clin,2005,23(3):319-330.
2. 王海燕.肾脏病学[M].北京:人民卫生出版社，1996:597.
3. Stenvinkel P,Heimburger O,Paultre F,et al.Strong association between malnutrition，inflammation，and atherosclerosis in chronic renal failure[J].KidneyInt，1999，55（5）：1899-1911.
4. Menon V，Wang X，Greene T，et al.Relationship between C-reactive protein，albumin，and cardiovascular disease in patients with chronic kidney disease[J].Am J Kidney Dis，2003，42（1）：44-52.
5. Prieto D,Benedito S,Simonsen U,et al.Regional heterogeneity in the contractile and potentiating effects of neuropeptide Y in rat isolated coronary arteries:Modulatory action of endothelium[J].Br J Pharmacol,1991,102(3):754-758.
6. Kalantar ZK,Stenvinkel P,Bross R,et al.Kidney insufficiency and nutrient-based modulation of imflammation[J].Curr Opin Clin NutrMetab Care,2005,8(4):388-396.
7. Efendic E,Lindholm B,Bergstrom J,et al.Strong connection between malnutrition,inflammation and arteriosclerosis.Improved treatment of renal failure if underlying factors are attacked[J].Lakartidningen,1999,96(42):4538-4542.
8. Bergstrom J,Lindholm B.Malnutrition,cardiac disease,and mortality:an integrated point of view[J].Am J Kidney Dis,1998,32(5):834-841.
9. Tetta C,Biasioli S,Schiavon R,et al.An overview of haemodialysis and oxidant stress[J].Blood Purif,1999,17:118－126.
10. Morena M,Cristol JP,Canaud B,et al.Why hemodialysis patients are in a prooxidant state?What could be done to correct the pro/antioxidant imbalance[J].Blood Purif,2000,18(3):191-199.
11. Wratten ML,Navino C,Tetta C,et al.Haemolipodialysis[J].Blood Purif,1999,17:127-133.
12. Danielski M，Ikizler TA，McMonagle E，et al.Linkage of hypoalbuminemia，inflammation，and oxidative stress in patients receiving maintenance hemodialysis therapy[J].Am J Kidney Dis,2003,42:286-294.Morewr M,CristalJP,Canaud B.Blood Psuif,2000,18:191-199.

West China Medical Journal

Inflammatoin，Malnutrition and Lipid metabolism in Maintenance Hemodialysis Patients

Abstract Full text Figures/Tables Video References Cited by

Format

Content