The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria_West China Medical Journal

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银屑病; 蛋白尿; 病理

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目的：探讨银屑病合并蛋白尿患者的临床特点。方法：回顾性分析1996年1月～2005年8月收治的银屑病合并蛋白尿者临床资料，并与银屑病非蛋白尿者的临床特点比较。结果：银屑病合并不明原因蛋白尿48例，皮肤受累面积与蛋白尿程度无相关关系（P＞0.05），但银屑病合并蛋白尿组的银屑病病程更短,肾脏病理荧光表现为IgA沉积为主。蛋白尿组皮肤受累面积与非蛋白尿组皮肤受累面积比较，无统计学意义（P＞0.05），蛋白尿组和非蛋白尿组的病程也无统计学差异（P＞0.05）。结论：银屑病合并不明原因蛋白尿值得重视，有必要对其发病机制、临床特点、病理特征进行深入的研究。

Citation： ZHONG Hui,MA Aijing,JIANG Xian. The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria. West China Medical Journal, 2008, 23(1): 117-118. doi: Copy

1.	[１]Omdal R，Husby G．Renal affection in patients with ankylosing sponylitis and psoriatic arthritis[J]．Clin Rheumatol，1987,6(1):74-79．.
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5.	Yamamoto M,Yorioka T,et al.A Case of IgA nephropathy associated with psoriasis vulgaris[J].Nippon Jinzo Gakkai Shi，1994,36(6):779-783．.
6.	Tejinder S,Marjorie F,John J，et al.IgA nephropathy in psoriasis[J].Am J Nephrol，1998,18:425-429．.
7.	陈惠萍，王文荣，等．银屑病所致的肾损害[J].肾脏病与透析移植杂志，2003,12(4):393-396．.
8.	Yamaji H，Shikata K,Wada J,et al.A case of membranous nephropathy associated with psoriasis vulgaris[J].Acta Derm Venereol，1996,76(6):492．.
9.	Kida H,Asamoto T,Abe T,et al.Psoriasis vulgaris associated with mesangiocapillary glomerulonephritis[J].Clin Nephrol，1985,23(50）：255-257．.
10.	Saxena S,Verma K,Bhuyan UN,et al.Amyloidosis complicating psoriatic arthropathy[J].J Assoc Physicians India，1992,40(9):609-610．.
11.	Hall RP,Peck GL,Lawley TJ.Circulating IgA immune complexes in patients with psoriasis[J].J Invest Dermatol，1983,80(6):465-468．.
12.	杨剑辉，井艳华，张纪芸.银屑病患者肾脏损害的临床与病理观察[J].中华皮肤科杂志，2002，35（2）:155．.
13.	于厚南,梅长林，廖万清.银屑病并发慢性肾功能衰竭8例报道[J].肾脏病与透析肾移植杂志，1997,6(3)：242-243．.

1. [１]Omdal R，Husby G．Renal affection in patients with ankylosing sponylitis and psoriatic arthritis[J]．Clin Rheumatol，1987,6(1):74-79．.
2. Madeddu P，Ena P,Glorioso N,et al.High prevalence of microproteinuria,an early index of renal impairment,in patients withdiffuse psoriasis[J].Nephron，1988,48(3):222-225．.
3. Alenius GM,Stegmayr BG,Dahlqvist SR.Renalabnormalities in a population of patients with psoriatic arthritis[J].Scand JRheumatol，2001,30(5):271-4．.
4. Szepietowski JC,Bielicka E,Wasik F,et al.Microalbuminuria as a subclinical marker of renal in subjects with psoriasis vulgaris[J].J Eur Acad Dermatol Venereol，2000,14(6):513-514．.
5. Yamamoto M,Yorioka T,et al.A Case of IgA nephropathy associated with psoriasis vulgaris[J].Nippon Jinzo Gakkai Shi，1994,36(6):779-783．.
6. Tejinder S,Marjorie F,John J，et al.IgA nephropathy in psoriasis[J].Am J Nephrol，1998,18:425-429．.
7. 陈惠萍，王文荣，等．银屑病所致的肾损害[J].肾脏病与透析移植杂志，2003,12(4):393-396．.
8. Yamaji H，Shikata K,Wada J,et al.A case of membranous nephropathy associated with psoriasis vulgaris[J].Acta Derm Venereol，1996,76(6):492．.
9. Kida H,Asamoto T,Abe T,et al.Psoriasis vulgaris associated with mesangiocapillary glomerulonephritis[J].Clin Nephrol，1985,23(50）：255-257．.
10. Saxena S,Verma K,Bhuyan UN,et al.Amyloidosis complicating psoriatic arthropathy[J].J Assoc Physicians India，1992,40(9):609-610．.
11. Hall RP,Peck GL,Lawley TJ.Circulating IgA immune complexes in patients with psoriasis[J].J Invest Dermatol，1983,80(6):465-468．.
12. 杨剑辉，井艳华，张纪芸.银屑病患者肾脏损害的临床与病理观察[J].中华皮肤科杂志，2002，35（2）:155．.
13. 于厚南,梅长林，廖万清.银屑病并发慢性肾功能衰竭8例报道[J].肾脏病与透析肾移植杂志，1997,6(3)：242-243．.

West China Medical Journal

The Clinical Analysis of 48 Cases of Psoriasis with Proteinuria

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