Expressions of Chemokine Receptor CXCR4 and CCR7 in Thyroid Cancer and Its Clinicopathologic Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIONG Bin ¹ ,  WANG Chongshu. ²

1.The Third Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China;;
2.The First Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China;

Corresponding author：

WANG Chongshu., Email: wang@163.com

Keywords：

Thyroid cancer; CXCR4; CCR7

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ObjectiveTo investigate the expressions of chemokine receptor CXCR4 and CCR7 in thyroid cancer and its clinicopathologic significance. MethodsFifty-five patients with thyroid cancer were selected in the Affiliated Hospital of North Sichuan Medical College from 2006 to 2009, and 30 patients with thyroid adenoma were selected in the same hospital during 2009. The expressions of CXCR4 and CCR7 were detected in all the selected cases samples (including thyroid cancer and thyroid adenoma) by immunohistochemical SP technique. ResultsThe positive expression rates of CXCR4 and CCR7 in the thyroid cancer were higher than those in the thyroid adenoma (P lt;0.01), which in the thyroid cancer with clinical stage Ⅲ+Ⅳ were higher than those of the clinical stage Ⅰ+Ⅱ (P lt;0.05). The positive expression rate of CCR7 in the thyroid cancer with lymph node metastasis was higher than that of the thyroid cancer without lymph node metastasis (P lt;0.05), which of CXCR4 in the patients with thyroid cancer was independent of lymph node metastasis (P gt;0.05), and which of CXCR4 and CCR7 were also independent of the age and gender of the patients with thyroid cancer (P gt;0.05). The positive expressions of CCR7 and CXCR4 in all the patients with thyroid cancer was positively correlated (rs=0.491, P=0.000). ConclusionsCXCR4 and CCR7 are involved in the coordination of thyroid cancer progression. They can be used as prognostic indicators of thyroid cancer. High expression of CCR7 is prone to lymph node metastasis of thyroid cancer.

Citation： XIONG Bin,WANG Chongshu.. Expressions of Chemokine Receptor CXCR4 and CCR7 in Thyroid Cancer and Its Clinicopathologic Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(12): 1301-1304. doi: Copy

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2.	蔡伟, 刘丹丹, 康骅, 等. ET方案新辅助化疗对乳腺癌组织中CXCR4表达的影响及临床意义 [J]. 中国普外基础与临床杂志, 2010, 17(8): 812815, 823.
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22.	王明华, 黄铁柱, 惠震, 等. 趋化因子受体CXCR4在甲状腺癌中的表达 [J]. 肿瘤防治杂志, 2008, 35(2): 107109.
23.	Cabioglu N , Yazici M S, Arun B, et al. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer [J]. Clin Cancer Res, 2005,11(16): 56865693.

1. Müller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [J]. Nature, 2001, 410(6824): 5056.
2. 蔡伟, 刘丹丹, 康骅, 等. ET方案新辅助化疗对乳腺癌组织中CXCR4表达的影响及临床意义 [J]. 中国普外基础与临床杂志, 2010, 17(8): 812815, 823.
3. 邱明远, 李健文, 郑民华. CXCR4和CCR7在肿瘤中的进展研究 [J]. 中国癌症杂志, 2010, 20(30): 222226.
4. 熊斌, 王崇树. SDF1/CXCR4及CCL19/21CCR7与肿瘤的关系 [J]. 肿瘤预防与治疗, 2011, 24(2): 131133.
5. Spierings DC, de Vries EG, Vellenga E, et al. Tissue distribution of the death ligand TRAIL and its receptors [J]. J Histochem Cytochem, 2004, 52(6): 821831.
6. Yasuoka H, Kodama R, Hirokawa M, et al. CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis [J]. BMC Cancer, 2008, 8: 274282.
7. 关海霞, 单忠艳, 米小轶, 等. 普遍食盐碘化前后甲状腺癌发病变化的11年病理资料分析 [J]. 中国医科大学学报, 2006, 35(3): 284285.
8. 刘小华, 张敬杉, 陈金剑, 等. 甲状腺乳头状癌中央区淋巴结清扫术临床分析 [J]. 湖南医学, 2010, 21(20): 5859.
9. 沈强. 甲状腺癌颈淋巴结清扫术的几点看法 [J]. 外科理论与实践, 2009, 14(4): 379381.
10. Torregrossa L, Faviana P, Filice ME, et al. CXC chemokine receptor 4 immunodetection in the follicular variant of papillary thyroid carcinoma: comparison to galectin3 and Hector battifora mesothelial cell1 [J]. Thyroid, 2010, 20(5): 495504.
11. 蔚青, 金晓龙, 叶蕾, 等. IL13和CXCR4在甲状腺乳头状癌中的表达及其相关性 [J]. 中华内分泌外科杂志, 2010, 4(2): 7375.
12. Li YM, Pan Y, Wei Y, et al. Upregulation of CXCR4 is essential for HER2mediated tumor metastasis [J]. Cancer Cell, 2004, 6(5): 459469.
13. Sutton A, Friand V, BruléDonneger S, et al. Stromal cellderived factor1/chemokine (CXC motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion [J]. Mol Cancer Res, 2007, 5(1): 2133.
14. Castellone MD, Guarino V, De Falco V, et al. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas [J]. Oncogene, 2004, 23(35): 59585967.
15. Till KJ, Lin K, Zuzel M, et al. The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes [J]. Blood, 2002, 99(8): 29772984.
16. Ghobrial IM, Bone ND, Stenson MJ, et al. Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in Bcell chronic lymphocytic leukemia/ small lymphocytic lymphoma [J]. Mayo Clin Proc, 2004, 79(3): 318325.
17. 马飞, 宁力, 张颖妹, 等. 趋化因子受体CCR7促进乳腺癌细胞的趋化与侵袭 [J]. 第四军医大学学报, 2004, 25(20): 18831886.
18. Liu Y, Ji R, Li J, et al. Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis [J]. J Exp Clin Cancer Res, 2010, 29: 16.
19. Wagner PL, Moo TA, Arora N, et al. The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma [J]. Ann Surg Oncol, 2008, 15(10): 28332841.
20. González HE, Leiva A, Tobar H, et al. Altered chemokine receptor expression in papillary thyroid cancer [J]. Thyroid, 2009, 19(9): 957965.
21. 宝荣, 王佾, 张薇, 等. 甲状腺乳头状癌中趋化因子受体CCR7的表达 [J]. 第三军医大学学报, 2010, 32(14): 15861587.
22. 王明华, 黄铁柱, 惠震, 等. 趋化因子受体CXCR4在甲状腺癌中的表达 [J]. 肿瘤防治杂志, 2008, 35(2): 107109.
23. Cabioglu N , Yazici M S, Arun B, et al. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer [J]. Clin Cancer Res, 2005,11(16): 56865693.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions of Chemokine Receptor CXCR4 and CCR7 in Thyroid Cancer and Its Clinicopathologic Significance

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