Quantification of Liver Fat Content by 1H-MR Spectroscopy Imaging at 3.0 T for Therapeutic Evaluation of Fatty LiverPreliminary Study_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Xie ^1,2 , LIU Xijiao ¹ , HUANG Zixing ¹ , YUAN Fang ¹ ,  SONG Bin ¹ , ZHANG Wei . ¹

1.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;;
2.Department of Radiology, The Second People’s Hospital of Chengdu City, Chengdu 610017, Sichuan Province, China;

Corresponding author：

SONG Bin, Email: cjr.songbin@vip.163.com

Keywords：

Fatty liver; Functional magnetic resonance imaging; Proton magnetic resonance spectroscopy

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ObjectiveTo investigate the feasibility of proton magnetic resonance spectroscopy (1H-MRS) imaging, by which to quantitatively analyze liver fat content for therapeutic evaluation of fatty liver at 3.0 T MRI. MethodsTwenty-six patients who diagnosed with fatty liver were examined with proton MRS at Siemens Trio Tim 3.0 T MRI before treatment and 3, 6 months after treatment, respectively. The water peak, fat peak, water peak area, and fat peak area were detected, and the relative lipid content 1 (RLC1) and relative lipid content 2 (RLC2)were calculated. Fatty liver index (FLI) was referred to the standard which was calculated from triglycerides (TG), gammaglutamyl-transferase (GGT), waist circumference, and body mass index. ResultsThere were significantly different differences of RLC1 and RLC2 among before treatment and 3, 6 months after treatment (P lt;0.05). Compared with before treatment, the RLC1 and RLC2 values significantly decreased on month 3 or 6 after treatment (P lt;0.05). There were positive correlation between RLC1 or RLC2 and FLI (r=0.476, P lt;0.00; r=0.475, P lt;0.001). The intraclass correlation coefficient was more than 0.75 before treatment, the repeatability was better. ConclusionsProton MRS can quantitatively measure liver fat content. It can be reliably used for dynamic monitoring the therapeutic effects for fatty liver. Proton MRS is accurate, and has a good clinical application in dynamically monitoring the progression of fatty liver and evaluating the therapeutic effects of various treatments.

Citation： ZHANG Xie,LIU Xijiao,HUANG Zixing,YUAN Fang,SONG Bin,ZHANG Wei .. Quantification of Liver Fat Content by 1H-MR Spectroscopy Imaging at 3.0 T for Therapeutic Evaluation of Fatty LiverPreliminary Study. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(12): 1330-1333. doi: Copy

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14.	刘云霞, 王洁贞, 刘建平, 等. 脂肪肝影像学诊断性试验的系统评价 [J]. 中国医学科学院学报, 2004, 26（5）: 580584.
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18.	Rinella ME, McCarthy R, Thakrar K, et al. Dualecho, chemical shift gradientecho magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation [J]. Liver Transpl, 2003, 9(8): 851856.
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20.	FriedrichRust M, Müller C, Winckler A, et al. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MRspectroscopy, and serum markers [J]. J Clin Gastroenterol, 2010, 44(1): 5865.
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1. Bedogni G, Bellentani S, Miglioli L, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population [J]. BMC Gastroenterol, 2006, 6: 3339.
2. 范建高, 李新建, 朱军, 等. 上海市成人代谢综合征与脂肪肝关系分析 [J]. 中华内分泌代谢杂志, 2005, 21（4）: 306309.
3. 向国卿, 孟宪云, 张浩, 等. 脂肪肝相关危险因素的评估 [J]. 世界华人消化杂志, 2009, 17（10）: 10381041.
4. Hourigan KJ, Bowling FG. Alcoholic liver disease: a clinical series in an Australian private practice [J]. J Gastroenterol Hepatol, 2001, 16(10): 11381143.
5. NeuschwanderTetri BA. Fatty liver and nonalcoholic steatohepatitis [J]. Clin Cornerstone, 2001, 3(6): 4757.
6. Angulo P. GI epidemiology: nonalcoholic fatty liver disease [J]. Aliment Pharmacol Ther, 2007, 25(8): 883889.
7. 倪燕君, 刘厚钰, 胡德昌, 等. 脂肪肝临床病理分析 [J]. 中华消化杂志, 2001, 21（2）: 98101.
8. Diehl AM. Nonalcoholic steatohepatitis [J]. Semin Liver Dis, 1999, 19(2): 221229.
9. Targher G, Arcaro G. Nonalcoholic fatty liver disease and increased risk of cardiovascular disease [J]. Atherosclerosis, 2007, 191(2): 235240.
10. Graif M, Yanuka M, Baraz M, et al. Quantitative estimation of attenuation in ultrasound video images: correlation with histology in diffuse liver disease [J]. Invest Radiol, 2000, 35(5): 319324.
11. 李文政, 彭光春, 汤恢焕, 等. 脂肪肝CT、MRI定量诊断的对照实验研究 [J]. 医学影像学杂志, 2005, 15（4）: 294297.
12. 盛明洪, 吕斌, 周兴祥, 等. 二维超声图像定量诊断脂肪肝病变程度的应用研究 [J]. 临床超声医学杂志, 2005, 7（1）: 1820.
13. Kodama Y, Ng CS, Wu TT, et al. Comparison of CT methods for determining the fat content of the liver [J]. AJR Am J Roentgenol, 2007, 188(5): 13071312.
14. 刘云霞, 王洁贞, 刘建平, 等. 脂肪肝影像学诊断性试验的系统评价 [J]. 中国医学科学院学报, 2004, 26（5）: 580584.
15. 许骅, 王嵩, 耿道颖, 等. CT定量分析脂肪肝的临床应用初探 [J]. 中国医学计算机成像杂志, 2004, 10（4）: 250253.
16. Sanyal AJ; American Gastroenterological Association. AGA technical review on nonalcoholic fatty liver disease [J]. Gastroenterology, 2002, 123(5): 17051725.
17. Borra RJ, Salo S, Dean K, et al. Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with inphase and outofphase Mr imaging [J]. Radiology, 2009, 250(1): 130136.
18. Rinella ME, McCarthy R, Thakrar K, et al. Dualecho, chemical shift gradientecho magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation [J]. Liver Transpl, 2003, 9(8): 851856.
19. Cassidy FH, Yokoo T, Aganovic L, et al. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis [J]. Radiographics, 2009, 29(1): 231260.
20. FriedrichRust M, Müller C, Winckler A, et al. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MRspectroscopy, and serum markers [J]. J Clin Gastroenterol, 2010, 44(1): 5865.
21. Machann J, Thamer C, Schnoedt B, et al. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fatselective MRI and volumelocalized 1HMR spectroscopy [J]. Magn Reson Med, 2006, 55(4): 913917.
22. 赵黎明, 宋彬, 陈光文, 等. 肝脏脂肪含量MRI定量诊断与病理对照研究 [J]. 中国普外基础与临床杂志, 2011, 18（6）: 666671.
23. Kim H, Taksali SE, Dufour S, et al. Comparative MR study of hepatic fat quantification using singlevoxel proton spectroscopy, twopoint dixon and threepoint IDEAL [J]. Magn Reson Med, 2008, 59(3): 521527.
24. Ricci PE, Pitt A, Keller PJ, et al. Effect of voxel position on singlevoxel MR spectroscopy findings [J]. AJNR Am J Neuroradiol, 2000, 21(2): 367374.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Quantification of Liver Fat Content by 1H-MR Spectroscopy Imaging at 3.0 T for Therapeutic Evaluation of Fatty LiverPreliminary Study

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