Effects of NDRG1 and Advancement of It in Tumor Research_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MA Wei , SONG Yingjie , FAN Tao ,  WU Yunfei.

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;

Corresponding author：

WU Yunfei., Email: wuyunfei20092009@yahoo.cn

Keywords：

N-myc downstream regulated gene 1; Cell differentiation; Tumor; Research status

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Objective To summarize the role of N-myc downstream regulated gene 1 (NDRG1) and the advancement of it in tumor research. Methods Publications on line at home and abroad involving the roles of NDRG1 and the correlation between it and tumor were collected and reviewed. Results NDRG-1, has a number of important functions such as in organism responses in hypoxia, histological differentiation, and so on, especially plays a significant role in generation, metastasis, and invasion of cancer. Conclusion NDRG1 may be a candidate of metastasis relevant gene for cancer and may serve as a useful prognostic marker of carcinoma.

Citation： MA Wei,SONG Yingjie,FAN Tao,WU Yunfei.. Effects of NDRG1 and Advancement of It in Tumor Research. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(12): 1326-1329. doi: Copy

1.	van Belzen N, Dinjens WN, Diesveld MP, et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms [J]. Lab Invest, 1997; 77(1): 85-92.
2.	Kurdistani SK, Arizti P, Reimer CL, et al. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage [J]. Cancer Res, 1998; 58(19): 4439-4444.
3.	Guan RJ, Ford HL, Fu Y, et al. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer [J]. Cancer Res, 2000; 60(3): 749-755.
4.	Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes [J]. J Biol Chem, 1996; 271(47): 29659-29665.
5.	Zhou RH, Kokame K, Tsukamoto Y, et al. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart [J]. Genomics, 2001; 73(1): 86-97.
6.	Lachat P, Shaw P, Gebhard S, et al. Expression of NDRG1, a differentiation-related gene, in human tissues [J]. Histochem Cell Biol, 2002; 118(5): 399-408.
7.	Piquemal D, Joulia D, Balaguer P, et al. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells [J]. Biochim Biophys Acta, 1999; 1450(3): 364-373.
8.	Gómez-Casero E, Navarro M, Rodríguez-Puebla ML, et al. Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis [J]. Mol Carcinog, 2001; 32(2): 100-109.
9.	Angst E, Sibold S, Tiffon C, et al. Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer [J]. Br J Cancer, 2006; 95(3): 307-313.
10.	何静, 周柔丽. NDRG1基因与肝组织分化及癌变的相关性 [J]. 北京大学学报(医学版), 2003; 35(5): 471-475.
11.	Kim KT, Ongusaha PP, Hong YK, et al. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint [J]. J Biol Chem, 2004; 279(37): 38597-38602.
12.	Zhang P, Tchou-Wong KM, Costa M. Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter [J]. Cancer Res, 2007; 67(19): 9125-9133.
13.	Sibold S, Roh V, Keogh A, et al. Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma [J]. FEBS Lett, 2007; 581(5): 989-994.
14.	Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers [J]. BMC Genet, 2004; 5: 27.
15.	Chen B, Nelson DM, Sadovsky Y. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury [J]. J Biol Chem, 2006; 281(5): 2764-2772.
16.	Kalaydjieva L, Gresham D, Gooding R, et al. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom [J]. Am J Hum Genet, 2000; 67(1): 47-58.
17.	Okuda T, Higashi Y, Kokame K, et al. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves [J]. Mol Cell Biol, 2004; 24(9): 3949-3956.
18.	Ulrix W, Swinnen JV, Heyns W, et al. The differentiation-related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cells [J]. FEBS Lett, 1999; 455(1-2): 23-26.
19.	Tu LC, Yan X, Hood L, et al. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells [J]. Mol Cell Proteomics, 2007; 6(4): 575-588.
20.	Fotovati A, Fujii T, Yamaguchi M, et al. 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells [J]. Clin Cancer Res, 2006; 12(10): 3010-3018.
21.	Stein S, Thomas EK, Herzog B, et al. NDRG1 is necessary for p53-dependent apoptosis [J].J Biol Chem, 2004; 279(47): 48930-48940.
22.	Bandyopadhyay S, Pai SK, Hirota S, et al. PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer [J]. Cancer Res, 2004; 64(21): 7655-7660.
23.	Chen J, Li S, Yang Z, et al. Correlation between NDRG1 and PTEN expression in endometrial carcinoma [J]. Cancer Sci, 2008; 99(4): 706-710.
24.	Masuda K, Ono M, Okamoto M, et al. Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells [J]. Int J Cancer, 2003; 105(6): 803-810.
25.	Taketomi Y, Sugiki T, Saito T, et al. Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells [J]. Biochem Biophys Res Commun, 2003; 306(2): 339-346.
26.	Agarwala KL, Kokame K, Kato H, et al. Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein [J]. Biochem Biophys Res Commun, 2000; 272(3): 641-647.
27.	Kokame K, Kato H, Miyata T. Nonradioactive differential display cloning of genes induced by homocysteine in vascular endothelial cells [J]. Methods, 1998; 16(4): 434-443.
28.	Wang Z, Wang F, Wang WQ, et al. Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm [J]. World J Gastroenterol, 2004; 10(4): 550-554.
29.	王震, 刘乾, 陈琦, 等. NDRG1基因与乳腺癌转移的关系及其转染对乳腺癌细胞株增殖及侵袭力的影响 [J]. 中华病理学杂志, 2006; 35(6): 333-338.
30.	Nagai MA, Gerhard R, Fregnani JH, et al. Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients [J]. Breast Cancer Res Treat, 2010. [Epub ahead of print].
31.	Bandyopadhyay S, Pai SK, Gross SC, et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer [J]. Cancer Res, 2003; 63(8): 1731-1736.
32.	Song Y, Oda Y, Hori M, et al. N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin [J]. Hum Pathol, 2010; 41(2): 214-222.
33.	Maruyama Y, Ono M, Kawahara A, et al. Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis [J]. Cancer Res, 2006; 66(12): 6233-6242.
34.	Ando T, Ishiguro H, Kimura M, et al. Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma [J]. Dis Esophagus, 2006; 19(6): 454-458.
35.	Strzelczyk B, Szulc A, Rzepko R, et al. Identification of high-risk stage Ⅱ colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion [J]. Ann Surg Oncol, 2009; 16(5): 1287-1294.

1. van Belzen N, Dinjens WN, Diesveld MP, et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms [J]. Lab Invest, 1997; 77(1): 85-92.
2. Kurdistani SK, Arizti P, Reimer CL, et al. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage [J]. Cancer Res, 1998; 58(19): 4439-4444.
3. Guan RJ, Ford HL, Fu Y, et al. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer [J]. Cancer Res, 2000; 60(3): 749-755.
4. Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes [J]. J Biol Chem, 1996; 271(47): 29659-29665.
5. Zhou RH, Kokame K, Tsukamoto Y, et al. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart [J]. Genomics, 2001; 73(1): 86-97.
6. Lachat P, Shaw P, Gebhard S, et al. Expression of NDRG1, a differentiation-related gene, in human tissues [J]. Histochem Cell Biol, 2002; 118(5): 399-408.
7. Piquemal D, Joulia D, Balaguer P, et al. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells [J]. Biochim Biophys Acta, 1999; 1450(3): 364-373.
8. Gómez-Casero E, Navarro M, Rodríguez-Puebla ML, et al. Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis [J]. Mol Carcinog, 2001; 32(2): 100-109.
9. Angst E, Sibold S, Tiffon C, et al. Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer [J]. Br J Cancer, 2006; 95(3): 307-313.
10. 何静, 周柔丽. NDRG1基因与肝组织分化及癌变的相关性 [J]. 北京大学学报(医学版), 2003; 35(5): 471-475.
11. Kim KT, Ongusaha PP, Hong YK, et al. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint [J]. J Biol Chem, 2004; 279(37): 38597-38602.
12. Zhang P, Tchou-Wong KM, Costa M. Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter [J]. Cancer Res, 2007; 67(19): 9125-9133.
13. Sibold S, Roh V, Keogh A, et al. Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma [J]. FEBS Lett, 2007; 581(5): 989-994.
14. Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers [J]. BMC Genet, 2004; 5: 27.
15. Chen B, Nelson DM, Sadovsky Y. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury [J]. J Biol Chem, 2006; 281(5): 2764-2772.
16. Kalaydjieva L, Gresham D, Gooding R, et al. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom [J]. Am J Hum Genet, 2000; 67(1): 47-58.
17. Okuda T, Higashi Y, Kokame K, et al. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves [J]. Mol Cell Biol, 2004; 24(9): 3949-3956.
18. Ulrix W, Swinnen JV, Heyns W, et al. The differentiation-related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cells [J]. FEBS Lett, 1999; 455(1-2): 23-26.
19. Tu LC, Yan X, Hood L, et al. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells [J]. Mol Cell Proteomics, 2007; 6(4): 575-588.
20. Fotovati A, Fujii T, Yamaguchi M, et al. 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells [J]. Clin Cancer Res, 2006; 12(10): 3010-3018.
21. Stein S, Thomas EK, Herzog B, et al. NDRG1 is necessary for p53-dependent apoptosis [J].J Biol Chem, 2004; 279(47): 48930-48940.
22. Bandyopadhyay S, Pai SK, Hirota S, et al. PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer [J]. Cancer Res, 2004; 64(21): 7655-7660.
23. Chen J, Li S, Yang Z, et al. Correlation between NDRG1 and PTEN expression in endometrial carcinoma [J]. Cancer Sci, 2008; 99(4): 706-710.
24. Masuda K, Ono M, Okamoto M, et al. Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells [J]. Int J Cancer, 2003; 105(6): 803-810.
25. Taketomi Y, Sugiki T, Saito T, et al. Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells [J]. Biochem Biophys Res Commun, 2003; 306(2): 339-346.
26. Agarwala KL, Kokame K, Kato H, et al. Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein [J]. Biochem Biophys Res Commun, 2000; 272(3): 641-647.
27. Kokame K, Kato H, Miyata T. Nonradioactive differential display cloning of genes induced by homocysteine in vascular endothelial cells [J]. Methods, 1998; 16(4): 434-443.
28. Wang Z, Wang F, Wang WQ, et al. Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm [J]. World J Gastroenterol, 2004; 10(4): 550-554.
29. 王震, 刘乾, 陈琦, 等. NDRG1基因与乳腺癌转移的关系及其转染对乳腺癌细胞株增殖及侵袭力的影响 [J]. 中华病理学杂志, 2006; 35(6): 333-338.
30. Nagai MA, Gerhard R, Fregnani JH, et al. Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients [J]. Breast Cancer Res Treat, 2010. [Epub ahead of print].
31. Bandyopadhyay S, Pai SK, Gross SC, et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer [J]. Cancer Res, 2003; 63(8): 1731-1736.
32. Song Y, Oda Y, Hori M, et al. N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin [J]. Hum Pathol, 2010; 41(2): 214-222.
33. Maruyama Y, Ono M, Kawahara A, et al. Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis [J]. Cancer Res, 2006; 66(12): 6233-6242.
34. Ando T, Ishiguro H, Kimura M, et al. Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma [J]. Dis Esophagus, 2006; 19(6): 454-458.
35. Strzelczyk B, Szulc A, Rzepko R, et al. Identification of high-risk stage Ⅱ colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion [J]. Ann Surg Oncol, 2009; 16(5): 1287-1294.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of NDRG1 and Advancement of It in Tumor Research

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