Value of 1 H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAO Liming ,  SONG Bin , CHEN Guangwen , YUAN Fang , HUANG Zixing , YANG Ninjing.

Department of Radiology, West China Hospital, Sichuan University，Chengdu 610041, China;

Corresponding author：

SONG Bin, Email: ajr.songbin@vip.163.com

Keywords：

Hepatic steatosis; Proton magnetic resonance spectroscopy; Quantitative analysis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the diagnostic value of proton magnetic resonance spectroscopy （1 H-MRS） on the quantification of hepatic steatosis at 3.0 T MR united.
Methods Twenty-two patients who were candidated for liver surgery (living liver transplantation donor candidates, lobectomy or segmental resection for focal liver diseases, etc.) were enrolled in this study. 1 H-MRS was conducted with point resolved selective spectroscopy （PRESS） sequence, using SAGE software packages. The values of water peak (PW), lipid peak (PL) were measured, the area under water peak (AW) and lipid peak (AL), and then the relative lipid content of liver cells (RLC1, RLC2) was calculated. All subjects underwent surgical resection of liver shortly after MR scanning, fresh frozen specimens were obtained for Sudan Ⅲ staining, and staging was conducted.
Results In all 22 patients, 7 patients without fatty liver, 11 patients with mild fatty liver, 4 patients with moderate or severe fatty liver. Intercomparison between different histopathological grades showed following findings: the values of PL, AL, RLC1 and RLC2 had statistical significance (P lt;0.05). The values of PL， AL， RLC1 and RLC2 were positively correlated with the proportion of fatty degenerative cells (PFDC), P lt;0.05, and the highest correlation factor was 0.771 (RLC1 to the PFDC).
Conclusion 1 H-MRS can accurately quantify liver fat content and reflect the severity of hepatic steatosis. It has the potential to replace invasive liver biopsy.

Citation： ZHAO Liming,SONG Bin,CHEN Guangwen,YUAN Fang,HUANG Zixing,YANG Ninjing.. Value of 1 H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(1): 92-96. doi: Copy

1.	范建高，曾民德．脂肪肝的研究进展 [J]．胃肠病学和肝病学杂志， 1999； 8（2）： 149156.
2.	Marrero JA, Fontana RJ, Su GL, et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States [J]. Hepatology， 2002; 36（6）: 13491354.
3.	Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma [J]. Gastroenterology， 2002; 123（1）: 134140.
4.	中华肝脏病学会脂肪肝和乙醇性肝病学组．非酒精性肝病诊断标准 [J]．中华肝脏病杂志， 2003; 11（2）： 71.
5.	中华肝脏病学会脂肪肝和乙醇性肝病学组．酒精性脂肪性肝病诊断标准 [J]．中华肝脏病杂志， 2003； 11（2）： 72.
6.	张华捷，庄辉，刘学恩．脂肪肝的流行病学研究进展 [J]．中华流行病学杂志， 2004; 25（7）： 630631.
7.	孙艳，吴阳，刘兵，等．酒精性肝病的研究进展 [J]．吉林大学学报（医学版）， 2006; 32（4）： 733736.
8.	庄辉．酒精性肝病的流行病学 [J]．中华肝脏病杂志， 2003； 11（11）： 689.
9.	厉有名，陈卫星，虞朝辉，等．浙江省酒精性肝病流行病学调查概况 [J]．中华肝脏病杂志， 2003; 11（11）： 647649.
10.	郑瑞丹，陆伦根，孟家榕，等．非酒精性脂肪性肝病临床和病理学研究 [J]．中华肝脏病杂志， 2006; 14（6）： 449452.
11.	Te Sligte K， Bourass I， Sels JP， et al． Non  alcoholic steatohepatitis：review of a growing medical problem [J]． Eur J Intern Med， 2004; 15（1）: 1021.
12.	Gholam PM, Kotler DP, Flancbaum LJ. Liver pathology in morbidly obese patients undergoing RouxenY gastric bypass surgery [J]. Obes Surg， 2002; 12(1): 4951.
13.	Rinella ME， McCarthy R， Thakrar K， et al． Dualecho， chemical shift gradientecho magnetic resonance imaging to quantify hepatic steatosis： implications for living liver donation [J]． Liver Transpl， 2003; 9(8): 851856.
14.	Machann J， Thamer C， Schnoedt B， et al． Hepatic lipid accumulation in healthy subjects： a comparative study using spectral fatselective MRI and volumelocalized 1HMR spectroscopy [J]． Magn Reson Med， 2006； 55（4）： 913917.
15.	Limanond P， Raman SS， Lassman C， et al． Macrovesicular hepatic steatosis in living related liver donors： correlation between CT and histologic findings [J]． Radiology， 2004; 230（1）： 276280.
16.	Thomas EL， Hamilton G， Patel N， et al． Hepatic triglyceride content and its relation to body adiposity： a magnetic resonance imaging and proton magnetic resonance spectroscopy study [J]． Gut， 2005； 54（1）： 122127.
17.	范明霞，田建明，陆建平，等．活体1H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究 [J]．中国医学影像技术， 2004; 20（10）： 15031505.
18.	苏中振, 单鸿, 何炳钧, 等. STEAM和 PRESS序列在脂肪肝定量诊断中应用价值的对比研究 [J]. 中国介入影像与治疗学， 2008; 5(2): 9598.
19.	Vuppalanchi R, Cummings OW, Saxena R, et al. Relationship among histoligic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver sample [J]. J Clin Gastroenterol， 2007; 41(2): 206210.
20.	梁长虹, 刘于宝, 张中林, 等. 脂肪肝MR氢质子波谱成像定量分析的初步研究 [J]. 中华放射学杂志， 2007; 41（1）： 4346.

1. 范建高，曾民德．脂肪肝的研究进展 [J]．胃肠病学和肝病学杂志， 1999； 8（2）： 149156.
2. Marrero JA, Fontana RJ, Su GL, et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States [J]. Hepatology， 2002; 36（6）: 13491354.
3. Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma [J]. Gastroenterology， 2002; 123（1）: 134140.
4. 中华肝脏病学会脂肪肝和乙醇性肝病学组．非酒精性肝病诊断标准 [J]．中华肝脏病杂志， 2003; 11（2）： 71.
5. 中华肝脏病学会脂肪肝和乙醇性肝病学组．酒精性脂肪性肝病诊断标准 [J]．中华肝脏病杂志， 2003； 11（2）： 72.
6. 张华捷，庄辉，刘学恩．脂肪肝的流行病学研究进展 [J]．中华流行病学杂志， 2004; 25（7）： 630631.
7. 孙艳，吴阳，刘兵，等．酒精性肝病的研究进展 [J]．吉林大学学报（医学版）， 2006; 32（4）： 733736.
8. 庄辉．酒精性肝病的流行病学 [J]．中华肝脏病杂志， 2003； 11（11）： 689.
9. 厉有名，陈卫星，虞朝辉，等．浙江省酒精性肝病流行病学调查概况 [J]．中华肝脏病杂志， 2003; 11（11）： 647649.
10. 郑瑞丹，陆伦根，孟家榕，等．非酒精性脂肪性肝病临床和病理学研究 [J]．中华肝脏病杂志， 2006; 14（6）： 449452.
11. Te Sligte K， Bourass I， Sels JP， et al． Non  alcoholic steatohepatitis：review of a growing medical problem [J]． Eur J Intern Med， 2004; 15（1）: 1021.
12. Gholam PM, Kotler DP, Flancbaum LJ. Liver pathology in morbidly obese patients undergoing RouxenY gastric bypass surgery [J]. Obes Surg， 2002; 12(1): 4951.
13. Rinella ME， McCarthy R， Thakrar K， et al． Dualecho， chemical shift gradientecho magnetic resonance imaging to quantify hepatic steatosis： implications for living liver donation [J]． Liver Transpl， 2003; 9(8): 851856.
14. Machann J， Thamer C， Schnoedt B， et al． Hepatic lipid accumulation in healthy subjects： a comparative study using spectral fatselective MRI and volumelocalized 1HMR spectroscopy [J]． Magn Reson Med， 2006； 55（4）： 913917.
15. Limanond P， Raman SS， Lassman C， et al． Macrovesicular hepatic steatosis in living related liver donors： correlation between CT and histologic findings [J]． Radiology， 2004; 230（1）： 276280.
16. Thomas EL， Hamilton G， Patel N， et al． Hepatic triglyceride content and its relation to body adiposity： a magnetic resonance imaging and proton magnetic resonance spectroscopy study [J]． Gut， 2005； 54（1）： 122127.
17. 范明霞，田建明，陆建平，等．活体1H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究 [J]．中国医学影像技术， 2004; 20（10）： 15031505.
18. 苏中振, 单鸿, 何炳钧, 等. STEAM和 PRESS序列在脂肪肝定量诊断中应用价值的对比研究 [J]. 中国介入影像与治疗学， 2008; 5(2): 9598.
19. Vuppalanchi R, Cummings OW, Saxena R, et al. Relationship among histoligic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver sample [J]. J Clin Gastroenterol， 2007; 41(2): 206210.
20. 梁长虹, 刘于宝, 张中林, 等. 脂肪肝MR氢质子波谱成像定量分析的初步研究 [J]. 中华放射学杂志， 2007; 41（1）： 4346.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value of 1 H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System

Abstract Full text Figures/Tables Video References Cited by

Format

Content