Tumor Stem Cells in Gastrointestinal Tumorigenesis and Metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Peng , YU Jiwei , JIANG Bojian

*Department of General Surgery, No.3 Peoples Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, ChinaCorresponding Author: JIANG Bo-jian, E-mail: Jiang_md@hotmail.com;

Corresponding author：

Keywords：

Gastrointestinal; Neoplasm; Carcinoma; Stem cell; Metastasis【Foundation item】 Shanghai Jiao Tong University School of Medicine Research Fund (No.2007XY032)

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the status of tumor stem cells investigations in gastrointestinal carcinoma. Methods Domestic and international publications online involving tumor stem cells of gastrointestinal carcinoma in recent years were collected and reviewed. Results There are a small quantity of cancer cells shown some stem cell characteristics. They are named tumor stem cell and play an important role in tumorigenesis, proliferation, metastasis and recurrence. And also, tumor stem cells can resist the effect of antineoplastic drugs and lead to tumor recurrence. These tumor-initiating cells are CD133-positive in the gastrointestinal carcinomas, especially in colorectal cancers. CD133-positive colorectal cancer cells have the abilities of clone, proliferation, differentiation and form metastases. And a high CD133 mRNA content was found in the blood of patients who suffered from bone metastases. Conclusion The characteristics of CD133-positive cancer cell and the mechanisms of stem cell-niche system are the basis of developing better methods to tumor diagnosis and treatment, and provide theoretical basis of new methods, such as targeted therapy.

Citation： ZHANG Peng,YU Jiwei,JIANG Bojian. Tumor Stem Cells in Gastrointestinal Tumorigenesis and Metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(1): 81-84. doi: Copy

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4.	Singh SK, Hawkins C, Clarke ID, et al . Identification of human brain tumour initiating cells [J] . Nature, 2004; 432(7015)：396.
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8.	Collins AT, Berry PA, Hyde C, et al . Prospective identification of tumorigenic prostate cancer stem cells [J] . Cancer Res, 2005; 65(23)： 10946.
9.	Suetsugu A, Nagaki M, Aoki H, et al . Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells [J] . Biochem Biophys Res Commun, 2006; 351(4) ∶820.
10.	Yin S, Li J, Hu C, et al . CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity [J] . Int J Cancer, 2007; 120(7)： 1444.
11.	Haraguchi N, Ishikawa K, Kabahara Y, et al . Cancer stem cell and cancer metastasis [J] . Surgery Frontier , 2007; 14(4)： 60.
12.	Hiratsuka S, Nakamura K, Iwai S, et al . MMP-9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis [J] . Cancer Cell, 2002; 2(4)： 289.
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14.	朱军华，陶凯雄，王国斌. TNF-α对肝癌细胞VEGF和MMP-9表达的影响 [J] . 中国普外基础与临床杂志, 2005; 12(4)：384.
15.	Müller A, Homey B, Soto H, et al . Involvement of chemokine receptors in breast cancer metastasis [J] . Nature, 2001; 410 (6824)： 50.
16.	Wai PY, Kuo PC. The role of Osteopontin in tumor metastasis [J] . J Surg Res, 2004; 121(2)：228.
17.	Balic M, Lin H, Young L, et al . Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype [J] . Clin Cancer Res, 2006; 12(19)： 5615.
18.	Hugo H, Ackland ML, Blick T, et al . Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression [J] . J Cell Physiol, 2007; 213(2)： 374.
19.	Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions [J] . Nat Rev Mol Cell Biol, 2006; 7(2)： 131.
20.	Coussens LM, Tinkle CL, Hanahan D, et al . MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis [J] . Cell, 2000; 103(3)： 481.
21.	Lyden D, Hattori K, Dias S, et al . Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J] . Nat Med, 2001; 7(11)： 1194.
22.	Peters BA, Diaz LA, Polyak K, et al . Contribution of bone marrow-derived endothelial cells to human tumor vasculature [J] . Nat Med, 2005; 11(3)： 261.
23.	Kaplan RN, Riba RD, Zacharoulis S, et al . VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche [J] . Nature, 2005; 438(7069)： 820.
24.	Zlotnik A. New insights on the role of CXCR4 in cancer metastasis [J] . J Pathol, 2008; 215(3)： 211.
25.	Hemmati HD, Nakano I, Lazareff JA, et al . Cancerous stem cells can arise from pediatric brain tumors [J] . Proc Natl Acad Sci USA, 2003; 100(25)： 15178.
26.	Stingl J, Eirew P, Ricketson I, et al . Purification and unique properties of mammary epithelial stem cells [J] . Nature, 2006; 439(7079)： 993.
27.	Miraglia S, Godfrey W, Yin AH, et al . A novelfive-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning [J] . Blood, 1997; 90(12)： 5013.
28.	Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al . Identification and expansion of human colon-cancer-initiating cells [J] . Nature, 2007; 445(7123)： 111.
29.	Mehra N, Penning M, Maas J, et al . Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases [J] . Clin. Cancer Res, 2006; 12(16)： 4859.
30.	Corbeil D, Rper K, Hellwig A, et al . The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions [J] . J Biol Chem, 2000; 275(8)：5512.

1. 29 Takaishi S, Okumura T, Wang TC. Gastric cancer stem cell [J] . J Clin Oncol, 2008; 26(17)： 2876 30 Houghton J, Stoicov C, Nomura S, et al . Gastric cancer originating from bone marrow-derived cells [J] . Science, 2004; 306(5701)： 1568.
2. Hanahan D, Weinberg RA. The hallmarks of cancer [J] . Cell, 2000; 100(1)：57.
3. DAmour KA, Gage FH. Are somatic stem cells pluripotent or lineage-restricted? [J] . Nat Med, 2002; 8(3)： 213.
4. Singh SK, Hawkins C, Clarke ID, et al . Identification of human brain tumour initiating cells [J] . Nature, 2004; 432(7015)：396.
5. Lapidot T, Sirard C, Vormoor J, et al . A cell initiating human acute myeloid leukaemia after transplantation into SCID mice [J] . Nature, 1994; 367(6464)： 645.
6. Park CH, Bergsagel DE, McCulloch EA. Mouse myeloma tumor stem cells: a primary cell culture assay [J] . J Natl Cancer Inst, 1971; 46(2)： 411.
7. OBrien CA, Pollett A, Gallinger S, et al . A human colon cancer cell capable of initiating tumour growth in immunodeficient mice [J] . Nature, 2006; 445(7123)： 106.
8. Collins AT, Berry PA, Hyde C, et al . Prospective identification of tumorigenic prostate cancer stem cells [J] . Cancer Res, 2005; 65(23)： 10946.
9. Suetsugu A, Nagaki M, Aoki H, et al . Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells [J] . Biochem Biophys Res Commun, 2006; 351(4) ∶820.
10. Yin S, Li J, Hu C, et al . CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity [J] . Int J Cancer, 2007; 120(7)： 1444.
11. Haraguchi N, Ishikawa K, Kabahara Y, et al . Cancer stem cell and cancer metastasis [J] . Surgery Frontier , 2007; 14(4)： 60.
12. Hiratsuka S, Nakamura K, Iwai S, et al . MMP-9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis [J] . Cancer Cell, 2002; 2(4)： 289.
13. 张建军, 刘志明. MMP-9及TIMP-1在甲状腺癌组织及外周血中的表达及临床意义 [J] . 中国普外基础与临床杂志, 2007; 14(4)： 437.
14. 朱军华，陶凯雄，王国斌. TNF-α对肝癌细胞VEGF和MMP-9表达的影响 [J] . 中国普外基础与临床杂志, 2005; 12(4)：384.
15. Müller A, Homey B, Soto H, et al . Involvement of chemokine receptors in breast cancer metastasis [J] . Nature, 2001; 410 (6824)： 50.
16. Wai PY, Kuo PC. The role of Osteopontin in tumor metastasis [J] . J Surg Res, 2004; 121(2)：228.
17. Balic M, Lin H, Young L, et al . Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype [J] . Clin Cancer Res, 2006; 12(19)： 5615.
18. Hugo H, Ackland ML, Blick T, et al . Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression [J] . J Cell Physiol, 2007; 213(2)： 374.
19. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions [J] . Nat Rev Mol Cell Biol, 2006; 7(2)： 131.
20. Coussens LM, Tinkle CL, Hanahan D, et al . MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis [J] . Cell, 2000; 103(3)： 481.
21. Lyden D, Hattori K, Dias S, et al . Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J] . Nat Med, 2001; 7(11)： 1194.
22. Peters BA, Diaz LA, Polyak K, et al . Contribution of bone marrow-derived endothelial cells to human tumor vasculature [J] . Nat Med, 2005; 11(3)： 261.
23. Kaplan RN, Riba RD, Zacharoulis S, et al . VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche [J] . Nature, 2005; 438(7069)： 820.
24. Zlotnik A. New insights on the role of CXCR4 in cancer metastasis [J] . J Pathol, 2008; 215(3)： 211.
25. Hemmati HD, Nakano I, Lazareff JA, et al . Cancerous stem cells can arise from pediatric brain tumors [J] . Proc Natl Acad Sci USA, 2003; 100(25)： 15178.
26. Stingl J, Eirew P, Ricketson I, et al . Purification and unique properties of mammary epithelial stem cells [J] . Nature, 2006; 439(7079)： 993.
27. Miraglia S, Godfrey W, Yin AH, et al . A novelfive-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning [J] . Blood, 1997; 90(12)： 5013.
28. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al . Identification and expansion of human colon-cancer-initiating cells [J] . Nature, 2007; 445(7123)： 111.
29. Mehra N, Penning M, Maas J, et al . Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases [J] . Clin. Cancer Res, 2006; 12(16)： 4859.
30. Corbeil D, Rper K, Hellwig A, et al . The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions [J] . J Biol Chem, 2000; 275(8)：5512.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Tumor Stem Cells in Gastrointestinal Tumorigenesis and Metastasis

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