Expression of Stromal Cell-Derived Factor-1 and Its Clinical Significance in Blood Plasma of Patients with Breast Tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

TAO Jinbo , KANG Hua , HAI Tao , SUN Haichen , LIU Shuang

Department of General Surgery， Xuanwu Hospital， Capital Medical University, Beijing 100053， China;

Corresponding author：

Keywords：

Breast cancer; Stromal cell-derived factor-1; Lymph node; Metastasis

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Objective To investigate the expression of stromal cell-derived factor-1 (SDF-1) and its clinical significance in blood plasma of patients with breast tumor. Methods The level of SDF-1 protein was examined by enzyme linked immunosorbent assay (ELISA) in blood plasma of 26 patients with breast benign tumor and 52 patients with breast cancer. Results The SDF-1 protein in blood plasma was detected in both breast benign tumor patients and breast cancer ones. The level of SDF-1 protein in patients with breast cancer was higher than that in ones with breast benign tumor, and there was a statistical difference between them （P=0.000）. In patients with breast cancer, the level of SDF-1 protein in axillary lymph node (ALN) metastasis positive patients was significantly higher than that in ALN metastasis negative ones （P=0.036）. Conclusion The level of SDF-1 protein in blood plasma may be a specific tumor marker. Its level is correlated with lymph node involvement in breast cancer.

Citation： TAO Jinbo,KANG Hua,HAI Tao,SUN Haichen,LIU Shuang. Expression of Stromal Cell-Derived Factor-1 and Its Clinical Significance in Blood Plasma of Patients with Breast Tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(12): 914-916. doi: Copy

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1. Müller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [Ｊ]. Nature, 2001; 410(6824)∶50.
2. Nagasawa T, Kikutani H, Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor [Ｊ]. Proc Natl Acad Sci USA, 1994; 91(6)∶2305.
3. Netelenbos T, Zuijderduijn S, Van Den Born J, et al. Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells [Ｊ]. J Leukoc Biol, 2002; 72(2)∶353.
4. Yun HJ, Jo DY. Production of stromal cell-derived factor-1 (SDF-1)　and expression of CXCR4 in human bone marrow endothelial cells [Ｊ]. J Korean Med Sci, 2003; 18(5)∶679.
5. Nicolson GL. Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis [Ｊ]. Cancer Metastasis Rev, 1993; 12(3-4)∶325.
6. Arya M, Patel HR. Expanding role of chemokines and their receptors in cancer [Ｊ]. Expert Rev Anticancer Ther, 2003; 3(6)∶749.
7. Zlotnik A. Chemokines in neoplastic progression [Ｊ]. Semin Cancer Biol, 2004; 14(3)∶181.
8. 康骅， Robert EM, Wen GJ, 等. 基质细胞衍化因子-1的表达及其与乳腺癌患者预后的关系 [Ｊ]. 中国普外基础与临床杂志， 2005; 12(5)∶483.
9. 范素青, 陈伟, 陈海林. 基质细胞衍生因子-1在肺癌患者外周血中的表达及其临床意义 [Ｊ]. 安徽医药， 2006; 10(5)∶366.
10. Taichman RS, Cooper C, Keller ET, et al. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone [Ｊ]. Cancer Res, 2002; 62(6)∶1832.
11. Ishibe N, Albitar M, Jilani IB, et al. CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not [Ｊ]. Blood, 2002; 100(3)∶1100.
12. Oonakahara K, Matsuyama W, Higashimoto I, et al. Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space [Ｊ]. Am J Respir Cell Mol Biol, 2004; 30(5)∶671.
13. Kryczek I, Lange A, Mottram P, et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers [Ｊ]. Cancer Res, 2005; 65(2)∶465.
14. Yasumoto K, Koizumi K, Kawashima A, et al. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer [Ｊ]. Cancer Res, 2006; 66(4)∶2181.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Stromal Cell-Derived Factor-1 and Its Clinical Significance in Blood Plasma of Patients with Breast Tumor

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