Importance of Preoperative Solid Superselective Intra-Arterial Infusion Chemotherapy in Lowering Stage for Breast-Conserving Treatment of Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

何劲松 ¹ , 朱国献 ¹ , 郭良峰 ¹ , 陈伟财 ¹ , 周汝明 ² , 王先明 ¹

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Keywords：

乳腺癌; 立体超选择性动脉灌注化疗; 乳腺癌保乳手术

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目的评价术前立体超选择性动脉灌注化疗在ⅡB～ⅢA期乳腺癌保留乳房手术中的价值。方法 36例乳腺癌患者，其中ⅡB期10例、ⅢA期26，术前采用立体超选择性动脉灌注丝裂霉素、表阿霉素和5-氟尿嘧啶，化疗后再进行手术。结果 36例患者灌注化疗后病灶缓解32例，好转3例，无明显变化1例; 缓解率达88.9%（32/36），该32例患者肿瘤直径均缩小到2 cm以下，获得保乳手术机会。结论术前立体超选择性动脉灌注化疗可使局部晚期乳腺癌降期获得保乳机会。

Citation： 何劲松,朱国献,郭良峰,陈伟财,周汝明,王先明. Importance of Preoperative Solid Superselective Intra-Arterial Infusion Chemotherapy in Lowering Stage for Breast-Conserving Treatment of Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(12): 929-930. doi: Copy

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1. 王先明，何劲松，佟建蒙，等. 立体超选择动脉灌注化疗在治疗晚期乳腺癌中的临床应用 [J]. 外科理论与实践, 2006; 11(2)∶136.
2. 左文述主编. 现代乳腺肿瘤学 [M]. 第2版. 济南：山东科学技术出版社， 2006∶974~979.
3. 周永刚，魏玮. 乌金胶囊的制备及临床疗效观察 [J]. 江苏药学与临床研究， 2004; 12(5)∶47.
4. 李振主编. 恶性肿瘤的化学治疗与免疫治疗 [M]. 北京：人民卫生出版社， 1994∶59~61.
5. Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer [J]. N Engl J Med, 1989; 320(13)∶822.
6. Staradub VL, Hsieh YC, Clauson J, et al. Factors that influence surgical choices in women with breast carcinoma [J]. Cancer, 2002; 95(6)∶1185.
7. Nold RJ, Beamer RL, Helmer SD， et al． Factors influencing a woman’s choice to undergo breast-conserving surgery versus modified radical mastectomy [J]． Am J Surg, 2000; 180(6)∶413.
8. 刘力波，高丽华，李宽明，等. 灌注化疗栓塞后手术切除直肠癌31例报告 [J]. 中国普外基础与临床杂志， 2005; 12(5)∶512.
9. Bilbao JI, Rebollo J, Longo JM, et al. Neoadjuvant intra-arterial chemotherapy in inflammatory carcinoma of the breast [J]. Br J Radiol, 1992; 65(771)∶248.
10. Vanel D. Interventional radiology: the new daily work of the breast radiologist [J]． Eur J Radiol, 2002; 42(1)∶1.
11. 张保宁, 邵志敏, 乔新民，等．中国乳腺癌保乳治疗的前瞻性多中心研究 [J]．中华肿瘤杂志， 2005; 27(11)∶680.
12. Xing Y, Foy M, Cox DD, et al. Meta-analysis of sentinel lymph node biopsy after preoperative chemotherapy in patients with breast cancer [J]． Br J Surg, 2006; 93(5)∶539.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Importance of Preoperative Solid Superselective Intra-Arterial Infusion Chemotherapy in Lowering Stage for Breast-Conserving Treatment of Breast Cancer

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