A New Tool for Medical Research ——ATP-Binding Cassette Transporter Families_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Gaopeng ¹ , YE Lu ² , CHEN Xiaoping ¹

1. Department of Hepatic Surgery Center ;;
2. Department of Infection ;;
Tong ji Hospital , Huazhong University of Scienceand Technology , Wuhan 430030 , China;

Corresponding author：

Keywords：

ATP-binding cassette t ransporter family; 　　Multidrug resistance; 　　Stem cell

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Objective 　To review the application advancements of ATP-binding cassette (ABC) transporter in medical research.
Methods 　Relevant literatures about the applications of ABC families in medical research were reviewed. Results 　ABC families mainly took roles in transporting substances across cell membrane. Some of them were useful for the prediction of drug resistance and the prognosis of malignant tumors. Others were target s for molecular researches. Their expressions or mutations might be related with the occurrence of diseases. Conclusion ABC families are very important in the diagnosis and therapy for diseases. Thus they are very promising tools for future medical research.

Citation： LI Gaopeng ,YE Lu,CHEN Xiaoping. A New Tool for Medical Research ——ATP-Binding Cassette Transporter Families. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(1): 74-76. doi: Copy

1.	Annilo T,Chen ZQ,Shulenin S,et al.Evolution of the vertebrate ABC gene family:analysis of gene birth and death[J].Genomics,2006; 88(1)∶1.
2.	Kawabata S,Oka M,Shiozawa K,et al.Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells[J].Biochem Biophys Res Commun,2001; 280(5)∶1216.
3.	Bernstein PS,Leppert M,Singh N,et al.Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings[J].Invest Ophthalmol Vis Sci,2002; 43(2)∶466.
4.	Dean M,Hamon Y,Chimini G.The human ATP-binding cassette (ABC) transporter superfamily[J].J Lipid Res,2001; 42(7)∶1007.
5.	Ebert B,Seidel A,Lampen A.Identification of BCRP as transporter of benzo[a] pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists[J].Carcinogenesis,2005; 26(10)∶1754.
6.	Gillet JP,Efferth T,Steinbach D,et al.Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes[J].Cancer Res,2004; 64(24)∶8987.
7.	Honjo Y,Hrycyna CA,Yan QW,et al.Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells[J].Cancer Res,2001; 61(18)∶6635.
8.	Komatani H,Kotani H,Hara Y,et al.Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific,ATP-binding cassette transporter as a transporter of NB-506 and J-107088,topoisomerase Ⅰ inhibitors with an indolocarbazole structure[J].Cancer Res,2001; 61(7)∶2827.
9.	Sparreboom A,Loos WJ,Burger H,et al.Effect of ABCG2 genotype on the oral bioavailability of topotecan[J].Cancer Biol Ther,2005; 4(6)∶650.
10.	Suvannasankha A,Minderman H,O’Loughlin KL,et al.Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia:discordance between expression and function[J].Leukemia,2004; 18(7)∶1252.
11.	Uggla B,Sta°hl E,Wa°gster D,et al.BCRP mRNA expression v.clinical outcome in 40 adult AML patients[J].Leuk Res,2005; 29(2)∶141.
12.	Diestra JE,Condom E,Del Muro XG,et al.Expression of multidrug resistance proteins P-glycoprotein,multidrug resistance protein 1,breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy:biological and clinical implications[J].J Urol,2003; 170(4 Pt 1)∶1383.
13.	Burger H,Foekens JA,Look MP,et al.RNA expression of breast cancer resistance protein,lung resistance-related protein,multidrug resistance-associated proteins 1 and 2,and multidrug resistance gene 1 in breast cancer:correlation with chemotherapeutic response[J].Clin Cancer Res,2003; 9(2)∶827.
14.	王百林,杨海燕,翟淑萍,等.多药耐药相关蛋白基因、肺耐药蛋白基因在肝细胞癌中的表达及临床意义[J].中国普通外科杂志,2005; 14(2)∶95.
15.	王百林,陈孝平,翟淑萍,等.多药耐药相关蛋白基因、肺耐药蛋白基因与原发性肝细胞癌化疗敏感性研究[J].消化外科,2004; 3(2)∶100.
16.	权毅,严律南.多药耐药基因mdr1在肝细胞性肝癌中的表达及其意义[J].中国普外基础与临床杂志,2003; 10(4)∶370.
17.	Ohishi Y,Oda Y,Uchiumi T,et al.ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma[J].Clin Cancer Res,2002; 8(12)∶3767.
18.	Yoh K,Ishii G,Yokose T,et al.Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer[J].Clin Cancer Res,2004; 10(5)∶1691.
19.	Konig J,Hartel M,Nies AT,et al.Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma[J].Int J Cancer,2005; 115(3)∶359.
20.	Nakanishi T,Karp JE,Tan M,et al.Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients[J].Clin Cancer Res,2003; 9(9)∶3320.
21.	Dean M.The genetics of ATP-binding cassette transporters[J].Methods Enzymol,2005; 400∶409.
22.	Garmany TH,Moxley MA,White FV,et al.Surfactant composition and function in patients with ABCA3 mutations[J].Pediatr Res,2006; 59(6)∶801.
23.	Zhou S,Zong Y,Ney PA,et al.Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin Ⅸ levels[J].Blood,2005; 105(6)∶2571.
24.	Jonker JW,Buitelaar M,Wagenaar E,et al.The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria[J].Proc Natl Acad Sci USA,2002; 99(24)∶15649.
25.	罗华友,严律南,杨家印,等.ASODN逆转耐药肝癌细胞多药耐药基因mdr1的体内实验研究[J].中国普外基础与临床杂志,2004; 11(2)∶142.
26.	Wu H,Hait WN,Yang JM.Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells[J].Cancer Res,2003; 63(7)∶1515.
27.	Tahara H,Kusuhara H,Fuse E,et al.P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier,but only a limited role in its biliary excretion[J].Drug Metab Dispos,2005; 33(7)∶963.
28.	Xia CQ,Liu N,Yang D,et al.Expression,localization,and functional characteristics of breast cancer resistance protein in Caco-2 cells[J].Drug Metab Dispos,2005; 33(5)∶637.
29.	Zhou XF,Yang X,Wang Q,et al.Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein:in vitro and in vivo studies[J].Drug Metab Disposm,2005; 33(8)∶1220.
30.	Pavek P,Merino G,Wagenaar E,et al.Human breast cancer resistance protein:interactions with steroid drugs,hormones,the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine,and transport of cimetidine[J].J Pharmacol Exp Ther,2005; 312(1)∶144.
31.	Abbott BL.ABCG2 (BCRP) expression in normal and malignant hematopoietic cells[J].Hematol Oncol,2003; 21(3)∶115.
32.	Redvers RP,Li A,Kaur P.Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells[J].Proc Natl Acad Sci USA,2006; 103(35)∶13168.
33.	Dean M,Annilo T.Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates[J].Annu Rev Genomics Hum Genet,2005; 6∶123.

1. Annilo T,Chen ZQ,Shulenin S,et al.Evolution of the vertebrate ABC gene family:analysis of gene birth and death[J].Genomics,2006; 88(1)∶1.
2. Kawabata S,Oka M,Shiozawa K,et al.Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells[J].Biochem Biophys Res Commun,2001; 280(5)∶1216.
3. Bernstein PS,Leppert M,Singh N,et al.Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings[J].Invest Ophthalmol Vis Sci,2002; 43(2)∶466.
4. Dean M,Hamon Y,Chimini G.The human ATP-binding cassette (ABC) transporter superfamily[J].J Lipid Res,2001; 42(7)∶1007.
5. Ebert B,Seidel A,Lampen A.Identification of BCRP as transporter of benzo[a] pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists[J].Carcinogenesis,2005; 26(10)∶1754.
6. Gillet JP,Efferth T,Steinbach D,et al.Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes[J].Cancer Res,2004; 64(24)∶8987.
7. Honjo Y,Hrycyna CA,Yan QW,et al.Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells[J].Cancer Res,2001; 61(18)∶6635.
8. Komatani H,Kotani H,Hara Y,et al.Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific,ATP-binding cassette transporter as a transporter of NB-506 and J-107088,topoisomerase Ⅰ inhibitors with an indolocarbazole structure[J].Cancer Res,2001; 61(7)∶2827.
9. Sparreboom A,Loos WJ,Burger H,et al.Effect of ABCG2 genotype on the oral bioavailability of topotecan[J].Cancer Biol Ther,2005; 4(6)∶650.
10. Suvannasankha A,Minderman H,O’Loughlin KL,et al.Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia:discordance between expression and function[J].Leukemia,2004; 18(7)∶1252.
11. Uggla B,Sta°hl E,Wa°gster D,et al.BCRP mRNA expression v.clinical outcome in 40 adult AML patients[J].Leuk Res,2005; 29(2)∶141.
12. Diestra JE,Condom E,Del Muro XG,et al.Expression of multidrug resistance proteins P-glycoprotein,multidrug resistance protein 1,breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy:biological and clinical implications[J].J Urol,2003; 170(4 Pt 1)∶1383.
13. Burger H,Foekens JA,Look MP,et al.RNA expression of breast cancer resistance protein,lung resistance-related protein,multidrug resistance-associated proteins 1 and 2,and multidrug resistance gene 1 in breast cancer:correlation with chemotherapeutic response[J].Clin Cancer Res,2003; 9(2)∶827.
14. 王百林,杨海燕,翟淑萍,等.多药耐药相关蛋白基因、肺耐药蛋白基因在肝细胞癌中的表达及临床意义[J].中国普通外科杂志,2005; 14(2)∶95.
15. 王百林,陈孝平,翟淑萍,等.多药耐药相关蛋白基因、肺耐药蛋白基因与原发性肝细胞癌化疗敏感性研究[J].消化外科,2004; 3(2)∶100.
16. 权毅,严律南.多药耐药基因mdr1在肝细胞性肝癌中的表达及其意义[J].中国普外基础与临床杂志,2003; 10(4)∶370.
17. Ohishi Y,Oda Y,Uchiumi T,et al.ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma[J].Clin Cancer Res,2002; 8(12)∶3767.
18. Yoh K,Ishii G,Yokose T,et al.Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer[J].Clin Cancer Res,2004; 10(5)∶1691.
19. Konig J,Hartel M,Nies AT,et al.Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma[J].Int J Cancer,2005; 115(3)∶359.
20. Nakanishi T,Karp JE,Tan M,et al.Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients[J].Clin Cancer Res,2003; 9(9)∶3320.
21. Dean M.The genetics of ATP-binding cassette transporters[J].Methods Enzymol,2005; 400∶409.
22. Garmany TH,Moxley MA,White FV,et al.Surfactant composition and function in patients with ABCA3 mutations[J].Pediatr Res,2006; 59(6)∶801.
23. Zhou S,Zong Y,Ney PA,et al.Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin Ⅸ levels[J].Blood,2005; 105(6)∶2571.
24. Jonker JW,Buitelaar M,Wagenaar E,et al.The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria[J].Proc Natl Acad Sci USA,2002; 99(24)∶15649.
25. 罗华友,严律南,杨家印,等.ASODN逆转耐药肝癌细胞多药耐药基因mdr1的体内实验研究[J].中国普外基础与临床杂志,2004; 11(2)∶142.
26. Wu H,Hait WN,Yang JM.Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells[J].Cancer Res,2003; 63(7)∶1515.
27. Tahara H,Kusuhara H,Fuse E,et al.P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier,but only a limited role in its biliary excretion[J].Drug Metab Dispos,2005; 33(7)∶963.
28. Xia CQ,Liu N,Yang D,et al.Expression,localization,and functional characteristics of breast cancer resistance protein in Caco-2 cells[J].Drug Metab Dispos,2005; 33(5)∶637.
29. Zhou XF,Yang X,Wang Q,et al.Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein:in vitro and in vivo studies[J].Drug Metab Disposm,2005; 33(8)∶1220.
30. Pavek P,Merino G,Wagenaar E,et al.Human breast cancer resistance protein:interactions with steroid drugs,hormones,the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine,and transport of cimetidine[J].J Pharmacol Exp Ther,2005; 312(1)∶144.
31. Abbott BL.ABCG2 (BCRP) expression in normal and malignant hematopoietic cells[J].Hematol Oncol,2003; 21(3)∶115.
32. Redvers RP,Li A,Kaur P.Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells[J].Proc Natl Acad Sci USA,2006; 103(35)∶13168.
33. Dean M,Annilo T.Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates[J].Annu Rev Genomics Hum Genet,2005; 6∶123.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

A New Tool for Medical Research ——ATP-Binding Cassette Transporter Families

Abstract Full text Figures/Tables Video References Cited by

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