Pathogenesy and Therapeutic Prospect of Diabetes Mellitus Accompanied Lower Limb Vascular Lesion_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Rengui , ZHAO Jichun

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Diabetes mellitus; Vascular lesion; Treatment

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Objective　To investigate pathogenesy and therapeutic prospect of diabetes mellitus accompanied lower limb vascular lesion. Methods　Relevant literatures of recent years were reviewed. Results　Diabetes mellitus is one of the main risk factor causing peripheral artery disease. The site of vascular lesion often occur in major blood vessel and micrangium. The arterial sclerosis and decreased blood supply in microcirculation are important factors of lower limb ischemia. Lower limb ischemia in patients with diabetes mellitus is a common complication. Medical treatment and surgical treatment are the methods to improve symptoms of the complication. Conclusion　Surgical therapy is an effective method for the treatment of diabetes mellitus accompanied lower limb vascular lesion.

Citation： LIU Rengui,ZHAO Jichun. Pathogenesy and Therapeutic Prospect of Diabetes Mellitus Accompanied Lower Limb Vascular Lesion. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(6): 676-679. doi: Copy

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2.	粟　立. 糖尿病性下肢缺血的血管外科治疗 [J]. 首都医药， 1999； 6(5)∶44.
3.	Walters DP, Gatling W, Mullee MA, et al. The prevalence, detection, and epidemiological correlates of peripheral vascular disease: a comparison of diabetic and non-diabetic subjects in an English community [J]. Diabet Med, 1992; 9(8)∶710.
4.	LoGerfo FW, Coffman JD. Current concepts. Vascular and microvascular disease of the foot in diabetes. Implications for foot care [J]. N Engl J Med, 1984; 311(25)∶1615.
5.	Stonebridge PA, Murie JA. Infrainguinal revascularization in the diabetic patient [J]. Br J Surg, 1993; 80(10)∶1237.
6.	张培华主编. 临床血管外科学 [M]. 北京: 科学出版社, 2003∶2212~2215.
7.	张自杰. 糖尿病性神经病 [J]. 中华显微外科杂志， 1993; 16(3)∶230.
8.	刘　丽，靖冬梅, 王爱林. 血管内超声消融术治疗糖尿病足的疗效观察 [J]. 中华糖尿病杂志， 2004; 12(5)∶332.
9.	Akbari CM, Macsata R, Smith BM, et al. Overview of the diabetic foot [J]. Semin Vasc Surg, 2003; 16(1)∶3.
10.	许樟荣. 糖尿病足病变研究进展 [J]. 中国医师杂志， 2004； 6（1）∶1.
11.	Arora S, Pomposelli F, LoGerfo FW, et al. Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization [J]. J Vasc Surg, 2002; 35(3)∶501.
12.	Boulton AJ. Pressure and the diabetic foot: clinical science and offloading techniques [J]. Am J Surg, 2004; 187(5A)∶17S.
13.	曹永吉，李卫东. 2型糖尿病下肢血管病变形态学特点研究 [J]. 实用心脑肺血管病杂志， 2004； 12（2）∶107.
14.	Lavery LA, Baranoski S, Ayello EA. Options for off-loading the diabetic foot [J]. Adv Skin Wound Care, 2004; 17(4 Pt 1)∶181.
15.	Neder S, Nadash P. Individualized education can improve foot care for patients with diabetes [J]. Home Healthc Nurse, 2003; 21(12)∶837.
16.	高　杰, 李天宇，李令根. 糖尿病足治疗进展 [J]. 黑龙江中医药， 2003； 12(6)∶56.
17.	廉德胜. 糖尿病足的药物治疗 [J]. 中华现代临床医学杂志， 2003； 9(6)∶508.
18.	郑子恢. 安步乐克 [J]. 中国新药杂志, 1999; 8(11)∶772.
19.	Aszmann O, Tassler PL, Dellon AL. Changing the natural history of diabetic neuropathy: incidence of ulcer/amputation in the contralateral limb of patients with a unilateral nerve decompression procedure [J]. Ann Plast Surg, 2004; 53(6)∶517.
20.	Calhoun JH, Overgaard KA, Stevens CM, et al. Diabetic foot ulcers and infections: current concepts [J]. Adv Skin Wound Care, 2002; 15(1)∶31.
21.	Fowler EM, Vesely N, Johnson V, et al. Wound care for persons with diabetes [J]. Home Healthc Nurse, 2003; 21(8)∶531.
22.	邓福生，胡何节，王晓天，等. 糖尿病足的外科治疗 [J]. 中国临床保健杂志， 2004; 7(2)∶96.
23.	谷涌泉，齐立行. 糖尿病性下肢缺血病变的外科治疗 [J]. 中国现代手术学杂志， 2003; 7(2)∶101.
24.	Bommayya I, Edmonds M. The importance of infra-inguinal angioplasty in salvage of diabetic foot [C]. Neurodiab and DFSC of EASD Joint Meeting. Hungary, 2002∶130.
25.	Karacagil S, Almgren B, Bowald S, et al. Comparative analysis of patency, limb salvage and survival in diabetic and non-diabetic patients undergoing infrainguinal bypass surgery [J]. Diabet Med, 1995; 12(6)∶537.
26.	Kunlin J, Lengua F, Kunlin A, et al. New experimental documents on circulatory reversal by arteriovenous fistula in ischemia of the extremities [J]. J Mal Vasc, 1983; 8(4)∶287.
27.	王体沛. 糖尿病足的外科治疗 [J]. 内科急重症杂志， 2002； 8(1)∶39.
28.	杨晓凤, 吴雁翔, 王红梅. 自体外周血干细胞移植治疗糖尿病足26例临床研究 [J]. 中国实用内科杂志， 2004； 11(11)∶676.
29.	Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes [A]. In: Harris MI, Cowie CC, Stern MP, et al. eds. Diabetes in America [M]. 2nd ed. Washington DC: US Government Printing Office, 1995∶409-428.

1. 　Apelqvist J, Larsson J. What is the most effective way to reduce incidence of amputation in the diabetic foot? [J]. Diabetes Metab Res Rev, 2000; 16 Suppl 1∶S75.
2. 　粟　立. 糖尿病性下肢缺血的血管外科治疗 [J]. 首都医药， 1999； 6(5)∶44.
3. 　Walters DP, Gatling W, Mullee MA, et al. The prevalence, detection, and epidemiological correlates of peripheral vascular disease: a comparison of diabetic and non-diabetic subjects in an English community [J]. Diabet Med, 1992; 9(8)∶710.
4. 　LoGerfo FW, Coffman JD. Current concepts. Vascular and microvascular disease of the foot in diabetes. Implications for foot care [J]. N Engl J Med, 1984; 311(25)∶1615.
5. 　Stonebridge PA, Murie JA. Infrainguinal revascularization in the diabetic patient [J]. Br J Surg, 1993; 80(10)∶1237.
6. 　张培华主编. 临床血管外科学 [M]. 北京: 科学出版社, 2003∶2212~2215.
7. 　张自杰. 糖尿病性神经病 [J]. 中华显微外科杂志， 1993; 16(3)∶230.
8. 　刘　丽，靖冬梅, 王爱林. 血管内超声消融术治疗糖尿病足的疗效观察 [J]. 中华糖尿病杂志， 2004; 12(5)∶332.
9. 　Akbari CM, Macsata R, Smith BM, et al. Overview of the diabetic foot [J]. Semin Vasc Surg, 2003; 16(1)∶3.
10. 　许樟荣. 糖尿病足病变研究进展 [J]. 中国医师杂志， 2004； 6（1）∶1.
11. 　Arora S, Pomposelli F, LoGerfo FW, et al. Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization [J]. J Vasc Surg, 2002; 35(3)∶501.
12. 　Boulton AJ. Pressure and the diabetic foot: clinical science and offloading techniques [J]. Am J Surg, 2004; 187(5A)∶17S.
13. 　曹永吉，李卫东. 2型糖尿病下肢血管病变形态学特点研究 [J]. 实用心脑肺血管病杂志， 2004； 12（2）∶107.
14. 　Lavery LA, Baranoski S, Ayello EA. Options for off-loading the diabetic foot [J]. Adv Skin Wound Care, 2004; 17(4 Pt 1)∶181.
15. 　Neder S, Nadash P. Individualized education can improve foot care for patients with diabetes [J]. Home Healthc Nurse, 2003; 21(12)∶837.
16. 　高　杰, 李天宇，李令根. 糖尿病足治疗进展 [J]. 黑龙江中医药， 2003； 12(6)∶56.
17. 　廉德胜. 糖尿病足的药物治疗 [J]. 中华现代临床医学杂志， 2003； 9(6)∶508.
18. 　郑子恢. 安步乐克 [J]. 中国新药杂志, 1999; 8(11)∶772.
19. 　Aszmann O, Tassler PL, Dellon AL. Changing the natural history of diabetic neuropathy: incidence of ulcer/amputation in the contralateral limb of patients with a unilateral nerve decompression procedure [J]. Ann Plast Surg, 2004; 53(6)∶517.
20. 　Calhoun JH, Overgaard KA, Stevens CM, et al. Diabetic foot ulcers and infections: current concepts [J]. Adv Skin Wound Care, 2002; 15(1)∶31.
21. 　Fowler EM, Vesely N, Johnson V, et al. Wound care for persons with diabetes [J]. Home Healthc Nurse, 2003; 21(8)∶531.
22. 　邓福生，胡何节，王晓天，等. 糖尿病足的外科治疗 [J]. 中国临床保健杂志， 2004; 7(2)∶96.
23. 　谷涌泉，齐立行. 糖尿病性下肢缺血病变的外科治疗 [J]. 中国现代手术学杂志， 2003; 7(2)∶101.
24. 　Bommayya I, Edmonds M. The importance of infra-inguinal angioplasty in salvage of diabetic foot [C]. Neurodiab and DFSC of EASD Joint Meeting. Hungary, 2002∶130.
25. 　Karacagil S, Almgren B, Bowald S, et al. Comparative analysis of patency, limb salvage and survival in diabetic and non-diabetic patients undergoing infrainguinal bypass surgery [J]. Diabet Med, 1995; 12(6)∶537.
26. 　Kunlin J, Lengua F, Kunlin A, et al. New experimental documents on circulatory reversal by arteriovenous fistula in ischemia of the extremities [J]. J Mal Vasc, 1983; 8(4)∶287.
27. 　王体沛. 糖尿病足的外科治疗 [J]. 内科急重症杂志， 2002； 8(1)∶39.
28. 　杨晓凤, 吴雁翔, 王红梅. 自体外周血干细胞移植治疗糖尿病足26例临床研究 [J]. 中国实用内科杂志， 2004； 11(11)∶676.
29. 　Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes [A]. In: Harris MI, Cowie CC, Stern MP, et al. eds. Diabetes in America [M]. 2nd ed. Washington DC: US Government Printing Office, 1995∶409-428.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Pathogenesy and Therapeutic Prospect of Diabetes Mellitus Accompanied Lower Limb Vascular Lesion

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