Correlation Between Expression of Vascular Endothelial Growth Factor of Serum and Tumor Tissues and Clinical Prognosis in Patients with Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JING Jing , L Qing , LI Hongjiang , ZHENG Hong

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Vascular endothelial growth factor; Breast cancer; Prognosis

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Abstract Full text Figures/Tables Video References Cited by

bjective　To investigate the correlation between expression of vascular endothelial growth factor(VEGF) of serum and tumor tissues and the clinical prognosis in patients with breast cancer. Methods　The expressions of VEGF level of serum and tumor tissues in 44 patients with invasive duct breast cancer, 13 with benign breast diseases and 40 healthy controls. Serum VEGF level was measured by ELISA method. The protein expression of tissue VEGF, ER and C-erbB-2 were evaluated by immunohistochemistry LSAB method. Results　Serum VEGF level and tissue VEGF expression in breast cancer were higher than those in benign breast diseases （P＜0.001）, and there was no significance in benign breast diseases and healthy controls （P gt;0.05）. VEGF expression was correlated with lymph node metastasis (P＜0.01), ER and C-erbB-2 expression (P＜0.05, P＜0.01) and clinical stage （P＜0.01）. There were no statistical correlation between VEGF expression and age, tumor size (P gt;0.05). Conclusion　There is positively correlation between serum VEGF level and tissue VEGF expression, and between VEGF expression and clinic prognosis. Serum VEGF level may be one of important index of prognosis estimation in patients with breast cancer.

Citation： JING Jing,L Qing,LI Hongjiang,ZHENG Hong. Correlation Between Expression of Vascular Endothelial Growth Factor of Serum and Tumor Tissues and Clinical Prognosis in Patients with Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(6): 705-708. doi: Copy

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11.	Shih CH, Ozawa S, Ando N, et al. Vascular endothelial gro-wth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus [J]. Clin Cancer Res, 2000; 6(3)∶1161.
12.	Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth [J]. Cancer Res,2001;61(5)∶1786.
13.	Saaristo A, Karpanen T, Alitalo K. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis [J]. Oncogene, 2000; 19(53)∶6122.
14.	Hyder SM, Huang JC, Nawaz Z, et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins [J]. Environ Health Perspect, 2000; 108 Suppl 5∶785.
15.	Mueller MD, Vigne JL, Minchenko A, et al. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta [J]. Proc Natl Acad Sci USA, 2000; 97(20)∶10972.
16.	Murphy CE, Carder PJ, Lansdown MR, et al. Steroid hormone receptor expression in male breast cancer [J]. Eur J Surg Oncol, 2006; 32(1)∶44.
17.	Im SA, Kim SB, Lee MH, et al. Docetaxel plus epirubicin as first-line chemotherapy in MBC (KCSG 01-10-05): phase Ⅱ trial and the predictive values of circulating HER2 extracellular domain and vascular endothelial growth factor [J]. Oncol Rep, 2005; 14(2)∶481.
18.	Zhao J, Yan F, Ju H, et al. Correlation between serum vascular endothelial growth factor and endostatin levels in patients with breast cancer [J]. Cancer Lett, 2004; 204(1)∶87.

1. 　Zhang L, Hannay JA, Liu J, et al. Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance [J]. Cancer Res, 2006; 66(17)∶8770.
2. 　O’Shaughnessy JA. Molecular signatures predict outcomes of breast cancer [J]. N Engl J Med， 2006; 355(6)∶615.
3. 　Nasu R, Kimura H, Akagi K, et al. Blood flow influences vascular growth during tumour angiogenesis [J]. Br J Cancer, 1999; 79(5-6)∶780.
4. 　Vicioso L, Gonzalez FJ, Alvarez M, et al. Elevated serum levels of vascular endothelial growth factor are associated with tumor-associated macrophages in primary breast cancer [J]. Am J Clin Pathol, 2006; 125(1)∶111.
5. 　Ranieri G, Patruno R, Ruggieri E, et al. Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic [J]. Curr Med Chem, 2006; 13(16)∶1845.
6. 　王　良, 任国胜, 涂　刚，等. 外源性透明质酸酶对人乳腺癌细胞侵袭力及血管形成能力的影响 [J]. 中国普外基础与临床杂志, 2005; 12(3)∶216.
7. 　Vermeulen PB, Salven P, Benoy I, et al. Blood platelets and serum VEGF in cancer patients [J]. Br J Cancer, 1999; 79(2)∶370.
8. 　Kraft A, Weindel K, Ochs A, et al. Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease [J]. Cancer, 1999; 85(1)∶178.
9. 　Chin KF, Greenman J, Gardiner E, et al. Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer [J]. Br J Cancer, 2000; 83(11)∶1425.
10. 　Yamamoto Y, Toi M, Kondo S, et al. Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients [J]. Clin Cancer Res, 1996; 2(5)∶821.
11. 　Shih CH, Ozawa S, Ando N, et al. Vascular endothelial gro-wth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus [J]. Clin Cancer Res, 2000; 6(3)∶1161.
12. 　Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth [J]. Cancer Res,2001;61(5)∶1786.
13. 　Saaristo A, Karpanen T, Alitalo K. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis [J]. Oncogene, 2000; 19(53)∶6122.
14. 　Hyder SM, Huang JC, Nawaz Z, et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins [J]. Environ Health Perspect, 2000; 108 Suppl 5∶785.
15. 　Mueller MD, Vigne JL, Minchenko A, et al. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta [J]. Proc Natl Acad Sci USA, 2000; 97(20)∶10972.
16. 　Murphy CE, Carder PJ, Lansdown MR, et al. Steroid hormone receptor expression in male breast cancer [J]. Eur J Surg Oncol, 2006; 32(1)∶44.
17. 　 Im SA, Kim SB, Lee MH, et al. Docetaxel plus epirubicin as first-line chemotherapy in MBC (KCSG 01-10-05): phase Ⅱ trial and the predictive values of circulating HER2 extracellular domain and vascular endothelial growth factor [J]. Oncol Rep, 2005; 14(2)∶481.
18. 　Zhao J, Yan F, Ju H, et al. Correlation between serum vascular endothelial growth factor and endostatin levels in patients with breast cancer [J]. Cancer Lett, 2004; 204(1)∶87.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation Between Expression of Vascular Endothelial Growth Factor of Serum and Tumor Tissues and Clinical Prognosis in Patients with Breast Cancer

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