【Abstract】ObjectiveTo study the effects of endothelin (ET) and Xuesaitong injection on hepatic, renal and myocardial tissues after bile duct ligation (BDL) in rabbits.
MethodsSeventytwo rabbits were randomly divided into three groups: BDL group (24 rabbits), BDL+Xuesaitong injection group (24 rabbits), and sham operation group (24 rabbits). Each group was subdivided into four subgroups of postoperative 3, 6, 9 and 12 d (6 rabbits in each subgroup). Automatic biochemical analysis equipment was used to detect the levels of serum TBIL, ALT, BUN and Crea. The levels of ET in plasma, hepatic, renal and myocardial tissues were measured with radioimmunological method.
ResultsThe levels of ET in plasma, hepatic, renal and myocardial tissues in both BDL group and BDL+Xuesaitong injection group were higher than those of sham operation group (P<0.01). The levels of ET in plasma and tissues of BDL+Xuesaitong group were lower than those in BDL group (P<0.05).
ConclusionObstructive jaundice can lead to an increase of ET in plasma, hepatic, renal and myocardial tissues, the level of ET increases with the time of obstruction. Xuesaitong injection may play a protective role in the injury of hepatic, renal and myocardial tissues after obstruction by decreasing the level of ET in plasma and tissues.
Citation:
ZHOU Bin,YAO Nan,LI Yumin,SONG Shaoli.. Experimental Study on Effects of Endothelin and Xuesaitong Injection on Hepatic, Renal and Myocardial Tissues in Obstructive Jaundice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(1): 77-81. doi:
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- 1. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells [J]. Nature, 1988; 332(6163)∶411.
- 2. 李端阳, 李小英, 马庆久, 等. 大鼠梗阻性黄疸形成中血及肝组织内皮素的水平及意义 [J]. 武警医学, 2000; 11(8)∶454.
- 3. 刘颖斌, 蒋莜强, 刘峰, 等. 内皮素在梗阻性黄疸血液、肝、肾、胃及肺组织的含量变化和作用研究 [J]. 江西医学院学报, 1998; 38(3)∶21.
- 4. 刘宪生, 钱家勤. 梗阻性黄疸兔血浆内毒素和内皮素1含量与血流动力学改变的关系 [J]. 中华实验外科杂志, 1999; 16(2)∶157.
- 5. 彭兵, 吴言涛, 王向东, 等. 阻塞性黄疸患者手术前后内毒素、内皮素极细胞因子水平的研究 [J]. 中国普外基础与临床杂志, 2001; 8(4)∶245.
- 6. 张晋, 王晓良. 内皮源性血管活性因子的研究进展 [J]. 中国药理学通报, 2000; 16(1)∶11.
- 7. 马珂, 汤金土. 三七皂甙的实验研究进展 [J]. 浙江中西医结合杂志, 2002; 12(3)∶197.
- 8. 邱志兵, 李朝先. 内皮素与心肌缺血再灌注损伤 [J]. 国外医学·老年医学分册, 2001; 22(4)∶158.
- 9. 韩金安, 胡威夷. 三七总皂甙对中枢神经损伤氧自由基病理作用的影响 [J]. 中国药理学通报, 1996; 12(6)∶487.
- 10. Kim YH, Park KH, Rho HM. Transcriptional activation of the Cu,Znsuperoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng [J]. J Biol Chem, 1996; 271(40)∶24539.