Research Progression of Molecular Mechanism of Peritoneal Dissemination of Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HE Tao , YANG Zhiming , WU Xiaoting.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Gastric cancer Peritoneal metastasis Adhesive molecular

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【Abstract】ObjectiveTo investigate the molecular mechanism of peritoneal dissemination of gastric cancer.
MethodsLiteratures in recent years about mechanisms of peritoneal metastasis in gastric cancer were reviewed and summarized.
ResultsPeritoneal metastasis related to viability of cancer cells and peritoneal characteristics. Moreover, it is necessary that many adhesive moleculars, protein hydrolase, cell factors and vascular factors involved in peritoneal metastasis.
ConclusionPeritoneal metastasis of gastric cancer was induced by multiple factors together.

Citation： HE Tao,YANG Zhiming,WU Xiaoting.. Research Progression of Molecular Mechanism of Peritoneal Dissemination of Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(1): 43-45. doi: Copy

1.	Tsujitani S, Oka S, Suzuki K, et al. Prognostic factors in patients with advanced gastric cancer treated by noncurative resection: a multivariate analysis [J]. Hepatogastroenterology, 2001; 48(41)∶1504.
2.	Yoo CH, Noh SH, Shin DW, et al. Recurrence following curative resection for gastric carcinoma [J]. Br J Surg, 2000; 87(2)∶236.
3.	Maehara Y, Hasuda S, Koga T, et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer [J]. Br J Surg, 2000; 87(3)∶353.
4.	Nishimura S, Chung YS, Yashiro M, et al. Role of alpha 2 beta 1and alpha 3 beta 1integrin in the peritoneal implantation of scirrhous gastric carcinoma [J]. Br J Cancer, 1996; 74(9)∶1406.
5.	Maehara Y, Tomisaki S, Oda S, et al. Lymphatic advancement to peritoneal dissemination and liver metastasis in gastric cancer patients [J]. Anticancer Res, 1994; 14(6B)∶2755.
6.	Tanaka T, Kumagai K, Shimizu K, et al. Peritoneal metastasis in gastric cancer with particular reference to lymphatic advancement; extranodal invasion is a significant risk factor for peritoneal metastasis [J]. J Surg Oncol, 2000; 75(3)∶165.
7.	Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritoneal metastasis in human gastric cancer [J]. Cancer Res, 1981; 41(3)∶1236.
8.	Zhou YN, Xu CP, Han B, et al. Expression of Ecadherin and betacatenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival [J]. World J Gastroenterol, 2002; 8(6)∶987.
9.	Yonemura Y, Ninomiya I, Kaji M, et al. Decreased Ecadherin expression correlates with poor survival in patients with gastric cancer [J]. Anal Cell Pathol, 1995; 8(2)∶177.
10.	Yashiro M, Chung YS, Nishimura S, et al. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice [J]. Clin Exp Metastasis, 1996; 14(1)∶43.
11.	Matsuoka T, Yashiro M, Nishimura S, et al. Increased expression of alpha2beta1integrin in the peritoneal dissemination of human gastric carcinoma [J]. Int J Mol Med, 2000; 5(1)∶21.
12.	Ura H, Denno R, Hirata K, et al. Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma [J]. Surg Today, 1998; 28(10)∶1001.
13.	Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [J]. Anticancer Res, 1997; 17(1A)∶293.
14.	Nishimura S, Chung YS, Yashiro M, et al. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells [J]. Jpn J Cancer Res, 1996; 87(12)∶1235.
15.	Benchimol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule [J]. Cell, 1989; 57(2)∶327.
16.	Feng G, Tan Y. Expression and significance of MMP2 and type IV collagen in gastric cancer [J]. Zhonghua Waike Zazhi, 2000; 38(10)∶775.
17.	Yonemura Y, Endou Y, Fujita H, et al. Role of MMP7 in the formation of peritoneal dissemination in gastric cancer [J]. Gastric Cancer, 2000; 3(2)∶63.
18.	Senota A, Itoh F, Yamamoto H, et al. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer [J]. Clin Exp Metastasis, 1998; 16(4)∶313.
19.	Bando E, Yonemura Y, Endou Y, et al. Immunohistochemical study of MTMMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis [J]. Oncol Rep, 1998; 5(6)∶1483.
20.	Tahara E, Kuniyara H, Yasui W, et al. Abnormal expression growth factors and their receptors in stomach cancer [J]. Gann Monoger Cancer Res, 1994; 42(2)∶163.
21.	Tannapfel A, Wittekind C, Tahara E. Effect of hepatocyte growth factor (HGF)/scatter factor (SF) on cell adhesion in gastric cancer [J]. Z Gastroenterol, 1994; 32(2)∶91.
22.	Murakami N, Koufuji K, Shirouzu K. Influence of hepatocyte growth factor secreted from fibroblasts on the growth and invasion of scirrhous gastric cancer [J]. Int Surg, 2001; 86(3)∶151.
23.	Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [J]. Cancer, 1996; 77(5)∶858.
24.	Velikova G, Banks RE, Gearing A, et al. Circulating soluble adhesion molecules Ecadherin, Eselectin, intercellular adhesion molecule1 (ICAM1) and vascular cell adhesion molecule1 (VCAM1) in patients with gastric cancer [J]. Br J Cancer, 1997; 76(11)∶1398.

1. Tsujitani S, Oka S, Suzuki K, et al. Prognostic factors in patients with advanced gastric cancer treated by noncurative resection: a multivariate analysis [J]. Hepatogastroenterology, 2001; 48(41)∶1504.
2. Yoo CH, Noh SH, Shin DW, et al. Recurrence following curative resection for gastric carcinoma [J]. Br J Surg, 2000; 87(2)∶236.
3. Maehara Y, Hasuda S, Koga T, et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer [J]. Br J Surg, 2000; 87(3)∶353.
4. Nishimura S, Chung YS, Yashiro M, et al. Role of alpha 2 beta 1and alpha 3 beta 1integrin in the peritoneal implantation of scirrhous gastric carcinoma [J]. Br J Cancer, 1996; 74(9)∶1406.
5. Maehara Y, Tomisaki S, Oda S, et al. Lymphatic advancement to peritoneal dissemination and liver metastasis in gastric cancer patients [J]. Anticancer Res, 1994; 14(6B)∶2755.
6. Tanaka T, Kumagai K, Shimizu K, et al. Peritoneal metastasis in gastric cancer with particular reference to lymphatic advancement; extranodal invasion is a significant risk factor for peritoneal metastasis [J]. J Surg Oncol, 2000; 75(3)∶165.
7. Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritoneal metastasis in human gastric cancer [J]. Cancer Res, 1981; 41(3)∶1236.
8. Zhou YN, Xu CP, Han B, et al. Expression of Ecadherin and betacatenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival [J]. World J Gastroenterol, 2002; 8(6)∶987.
9. Yonemura Y, Ninomiya I, Kaji M, et al. Decreased Ecadherin expression correlates with poor survival in patients with gastric cancer [J]. Anal Cell Pathol, 1995; 8(2)∶177.
10. Yashiro M, Chung YS, Nishimura S, et al. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice [J]. Clin Exp Metastasis, 1996; 14(1)∶43.
11. Matsuoka T, Yashiro M, Nishimura S, et al. Increased expression of alpha2beta1integrin in the peritoneal dissemination of human gastric carcinoma [J]. Int J Mol Med, 2000; 5(1)∶21.
12. Ura H, Denno R, Hirata K, et al. Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma [J]. Surg Today, 1998; 28(10)∶1001.
13. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [J]. Anticancer Res, 1997; 17(1A)∶293.
14. Nishimura S, Chung YS, Yashiro M, et al. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells [J]. Jpn J Cancer Res, 1996; 87(12)∶1235.
15. Benchimol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule [J]. Cell, 1989; 57(2)∶327.
16. Feng G, Tan Y. Expression and significance of MMP2 and type IV collagen in gastric cancer [J]. Zhonghua Waike Zazhi, 2000; 38(10)∶775.
17. Yonemura Y, Endou Y, Fujita H, et al. Role of MMP7 in the formation of peritoneal dissemination in gastric cancer [J]. Gastric Cancer, 2000; 3(2)∶63.
18. Senota A, Itoh F, Yamamoto H, et al. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer [J]. Clin Exp Metastasis, 1998; 16(4)∶313.
19. Bando E, Yonemura Y, Endou Y, et al. Immunohistochemical study of MTMMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis [J]. Oncol Rep, 1998; 5(6)∶1483.
20. Tahara E, Kuniyara H, Yasui W, et al. Abnormal expression growth factors and their receptors in stomach cancer [J]. Gann Monoger Cancer Res, 1994; 42(2)∶163.
21. Tannapfel A, Wittekind C, Tahara E. Effect of hepatocyte growth factor (HGF)/scatter factor (SF) on cell adhesion in gastric cancer [J]. Z Gastroenterol, 1994; 32(2)∶91.
22. Murakami N, Koufuji K, Shirouzu K. Influence of hepatocyte growth factor secreted from fibroblasts on the growth and invasion of scirrhous gastric cancer [J]. Int Surg, 2001; 86(3)∶151.
23. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [J]. Cancer, 1996; 77(5)∶858.
24. Velikova G, Banks RE, Gearing A, et al. Circulating soluble adhesion molecules Ecadherin, Eselectin, intercellular adhesion molecule1 (ICAM1) and vascular cell adhesion molecule1 (VCAM1) in patients with gastric cancer [J]. Br J Cancer, 1997; 76(11)∶1398.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progression of Molecular Mechanism of Peritoneal Dissemination of Gastric Cancer

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