Bone Biochemical Markers in Bone Metastasis of Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LV Qing ¹ , XIAO Rong ²

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Biochemical marker; Breast cancer; Bone metastasis

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Objective To introduce the current studies on bone biochemical markers in breast cancer with bone metastasis.
Methods The papers in recent 8 years about the application of bone biochemical markers in the diagnosis and treatment of breast cancer with bone metastasis were reviewed.
Results NTX had the best relation with bone metastasis. ICTP was much more worthy than NTX in diagnosis of breast cancer with bone metastasis. Osteogenesis markers were little worthy in diagnosis of breast cancer with bone metastasis.
Conclusion Bone biochemical markers can not replace the image exams and biopsy in diagnosing the bone metastasis of breast cancer,but may be one of the factors to get the early diagnosis.

Citation： LV Qing,XIAO Rong. Bone Biochemical Markers in Bone Metastasis of Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(1): 29-31. doi: Copy

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1. Vinholes J, Coleman R, Lacombe D, et al. Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen crosslink exertion. European Organization for Research and Treatment of Cancer [J]. Br J Cancer, 1999; 80(1-2)∶221.
2. Fontana A, Delmas PD. Markers of bone turnover in bone metastases [J]. Cancer, 2000; 88(12 Suppl)∶2952.
3. Demers LM, Costa L, Chinchilli VM, et al. Biochemical markers of bone turnover in patients with metastatic bone disease [J]. Clin Chem, 1995; 41(10)∶1489.
4. Hou MF, Tsai LY, Tsai SM，et al. Biochemical markers for assessment of bone metastases in patients with breast cancer [J]. Kaohsiung J Med Sci, 1999; 15(8)∶452.
5. Clemens JD, Herrick MV, Singer FR, et al. Evidence that serum NTx(collagentype Ⅰ Ntelopeptides) can act as an immunochemical marker of bone resorption [J]. Clin Chem, 1997; 43(11)∶2058.
6. Wada N, Fujisaki M, Ishii S，et al. Evaluation of bone metabolic markers in breast cancer with bone metastasis [J]. Breast Cancer, 2001; 8(2)∶131.
7. Ulrich U, Rhiem K, Schmolling J, et al. Crosslinked type Ⅰ collagen C and Ntelopeptides in women with bone metastases from breast cancer [J]. Arch Gynecol Obstet, 2001; 264(4)∶186.
8. Kamby C, Egsmose C, Soletormos G, et al. The diagnostic and prognostic value of serum bone GLa protein(osteocalcin) in patients with recurrent breast cancer [J]. Scand J Clin Lab Invest, 1993; 53(5)∶439.
9. Keskikuru R, Kataja V, Kosma VM, et al. Preoperative high type Ⅰ collagen degradation marker ICTP reflects advanced breast cancer [J]. Anticancer Res, 1999; 19(5C)∶4481.
10. Shimozuma K, Sonoo H, Fukunaga M, et al. Biochemical markers of bone turnover in breast cancer patients with bone metastases: a prcliminary report [J]. Jpn J Clin Oncol, 1999; 29(1)∶16.
11. Yamamoto I, Miura H, Kigami Y, et al. Detection of bone metastasis by serial measurement of Cterminal telopeptide of type Ⅰ collagen in patients with malignancy [J]. Kaku Igaku, 1996; 33(4)∶423.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Bone Biochemical Markers in Bone Metastasis of Breast Cancer

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