Breast Cancer During Pregnancy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SHI Yuan , REN Guosheng

Department of General Surgery, The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China;

Corresponding author：

Keywords：

Pregnancy; Breast cancer; Diagnosis; Therapy; Prognosis

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Objective To study the advances in research of breast cancer during pregnancy.
Methods The literatures in recent years were reviewed.
Results A lot of evidences suggested that the diagnosis may be delayed easily. The diagnosis was primarily made by needle aspiration cytology and biopsy. The treatment of pregnant breast cancer was not different from ordinary breast cancer, however the factor of foetus should be taken into account. Termination of pregnancy did not improve survival.
Conclusion Pregnant breast cancer is mostly at later stage at the time of diagnosis and has poorer prognosis than ordinary breast cancer. The patients with breast cancer during pregnancy usually have an equivalent survival rate when compared with age and stagematched ordinary group. Future pregnancy may be allowed after two years of treatment in patients with early breast cancer.

Citation： SHI Yuan,REN Guosheng. Breast Cancer During Pregnancy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(1): 32-35. doi: Copy

1.	Petrek JA, Dukoff R, Rogatko A.Prognosis of pregnancy associated breast cancer [Ｊ]. Cancer， 1991; 67(4)∶869.
2.	Dimitrov G, Iovchev I. Breast cancer and pregnancy [Ｊ]. Khirurgiia (Sofiia)， 1997; 50(3)∶39.
3.	Kuerer HM, Cunningham JD, Brower ST, et al. Breast carcinoma associated with pregnancy and lactation [Ｊ]. Surg Oncol, 1997; 6(2)∶93.
4.	Elledge RM,Ciocca DR, Langone G,et al.Estrogen receptor, progesterone receptor, and HER2/neu protein in breast cancers from pregnant patients [Ｊ]. Cancer, 1993; 71(8)∶2499.
5.	White TT. Prognosis of breast cancer for pregnant and nursing women; analysis of 1 413 cases [J]. Surg Gynecol Obestet, 1955; 100(6)∶661.
6.	左文述，徐忠法，刘奇主编. 现代乳腺肿瘤学 [M]. 第1版. 济南：山东科学技术出版社， 1995∶516～519.
7.	李树玲主编. 乳腺肿瘤学 [M]. 北京：科学技术文献出版社，2000∶614～616.
8.	Barnavon Y, Wallack MK. Management of the pregnant patient with carcinoma of the breast [Ｊ]. Surg Gynecol Obstet, 1990; 171 (4)∶347.
9.	Gorins A, Lenhardt F, Espie M. Breast cancer during pregnancy. Epidemiologydiagnosisprognosis [Ｊ]. Contracept Fertil Sex, 1996; 24(2)∶153.
10.	李佩文，邹丽琰主编. 乳腺癌综合诊疗学 [M]. 北京：中国中医药出版社， 1999∶609～610.
11.	Lethaby AE, O’Neill MA, Mason BH, et al.Overall survival from breast cancer in women pregnant or lactating at or after diagnosis. Auckland Breast Cancer Study Group [Ｊ]. Int J Cancer, 1996; 67(6)∶751.
12.	Nettleton J, Long J, Kuban D, et al.Breast cancer during pregnancy: quantifying the risk of treatment delay [Ｊ].Obstet Gynecol, 1996; 87(3)∶414.
13.	Merkel DE. Pregnancy and breast cancer[Ｊ]. Semin Surg Oncol, 1996; 12(5)∶370.
14.	Samuels TH, Liu FF, Yaffe M, et al. Gestational breast cancer [Ｊ]. Can Assoc Radiol J, 1998; 49(3)∶172.
15.	ScottConner CE, Schorr SJ. The diagnosis and management of breast problems during pregnancy and lactation [Ｊ]. Am J Surg, 1995; 170(4)∶401.
16.	Byrd BF,Bayer DS,Robertson JC, et al. Treatment of breast tumor associated with pregnancy and lactation [Ｊ]. Ann Surg,1962; 155∶940.
17.	Difronzo LA, O’Connell TX. Breast cancer in pregnancy and lactation [Ｊ]. Surg Clin North Am, 1996; 76(2)∶267.
18.	Petrek JA. Breast cancer during pregnancy [Ｊ]. Cancer, 1994; 74(1)∶518.
19.	Mazze RI, Kallen B. Reproductive outcome after anesthesia and operation during pregnancy： a registry study of 5 405 cases [Ｊ]. Am J Obstet Gynecol, 1989; 161(5)∶1178.
20.	Gemignani ML, Petrek JA, Borgen PI. Breast cancer and pregnancy [Ｊ]. Surg Clin North Am, 1999; 79(5)∶1157.
21.	Petrek JA.Breast cancer during pregnancy [Ｊ]. Cancer , 1994; 74 (1 Suppl)∶518.
22.	Marchant DJ. Breast cancer in pregnancy [Ｊ]. Clin Obstet Gynecol, 1994; 37(4)∶993.
23.	Hoover HC Jr. Breast cancer during pregnancy and lactation [Ｊ] .Surg Clin North Am, 1990; 70(5)∶1151.
24.	Espie M, Cuvier C. Treating breast cancer during pregnancy. What can be taken safely? [Ｊ]. Drug Saf, 1998; 18(2)∶135.
25.	Espie M, Cuvier C.Treatment of breast cancer during pregnancy [Ｊ]. Contracept Fertil Sex, 1996; 24(11)∶805.
26.	Nugent P,O’Connell TX.Breast cancer and pregnancy [Ｊ]. Arch Surg, 1985； 120(11)∶1221.
27.	Malamos NA,Stathopoulos GP,Keramopoulos A, et al.Pregnancy and offspring after the appearance of breast cancer [Ｊ]. Oncology, 1996; 53(6)∶ 471.
28.	Collichio FA, Agnello R, Staltzer J. Pregnancy after breast cancer: from psychosocial issues through conception [Ｊ]. Oncology (Huntingt), 1998； 12(5)∶759.
29.	Ariel IM, Kempner R. The prognosis of patients who become pregnant after mastectomy for breast cancer [Ｊ]. Int Surg, 1989; 74(3)∶185.
30.	Petrek JA. Pregnancy safety after breast cancer [Ｊ]. Cancer, 1994; 74(1 Suppl)∶528.

1. Petrek JA, Dukoff R, Rogatko A.Prognosis of pregnancy associated breast cancer [Ｊ]. Cancer， 1991; 67(4)∶869.
2. Dimitrov G, Iovchev I. Breast cancer and pregnancy [Ｊ]. Khirurgiia (Sofiia)， 1997; 50(3)∶39.
3. Kuerer HM, Cunningham JD, Brower ST, et al. Breast carcinoma associated with pregnancy and lactation [Ｊ]. Surg Oncol, 1997; 6(2)∶93.
4. Elledge RM,Ciocca DR, Langone G,et al.Estrogen receptor, progesterone receptor, and HER2/neu protein in breast cancers from pregnant patients [Ｊ]. Cancer, 1993; 71(8)∶2499.
5. White TT. Prognosis of breast cancer for pregnant and nursing women; analysis of 1 413 cases [J]. Surg Gynecol Obestet, 1955; 100(6)∶661.
6. 左文述，徐忠法，刘奇主编. 现代乳腺肿瘤学 [M]. 第1版. 济南：山东科学技术出版社， 1995∶516～519.
7. 李树玲主编. 乳腺肿瘤学 [M]. 北京：科学技术文献出版社，2000∶614～616.
8. Barnavon Y, Wallack MK. Management of the pregnant patient with carcinoma of the breast [Ｊ]. Surg Gynecol Obstet, 1990; 171 (4)∶347.
9. Gorins A, Lenhardt F, Espie M. Breast cancer during pregnancy. Epidemiologydiagnosisprognosis [Ｊ]. Contracept Fertil Sex, 1996; 24(2)∶153.
10. 李佩文，邹丽琰主编. 乳腺癌综合诊疗学 [M]. 北京：中国中医药出版社， 1999∶609～610.
11. Lethaby AE, O’Neill MA, Mason BH, et al.Overall survival from breast cancer in women pregnant or lactating at or after diagnosis. Auckland Breast Cancer Study Group [Ｊ]. Int J Cancer, 1996; 67(6)∶751.
12. Nettleton J, Long J, Kuban D, et al.Breast cancer during pregnancy: quantifying the risk of treatment delay [Ｊ].Obstet Gynecol, 1996; 87(3)∶414.
13. Merkel DE. Pregnancy and breast cancer[Ｊ]. Semin Surg Oncol, 1996; 12(5)∶370.
14. Samuels TH, Liu FF, Yaffe M, et al. Gestational breast cancer [Ｊ]. Can Assoc Radiol J, 1998; 49(3)∶172.
15. ScottConner CE, Schorr SJ. The diagnosis and management of breast problems during pregnancy and lactation [Ｊ]. Am J Surg, 1995; 170(4)∶401.
16. Byrd BF,Bayer DS,Robertson JC, et al. Treatment of breast tumor associated with pregnancy and lactation [Ｊ]. Ann Surg,1962; 155∶940.
17. Difronzo LA, O’Connell TX. Breast cancer in pregnancy and lactation [Ｊ]. Surg Clin North Am, 1996; 76(2)∶267.
18. Petrek JA. Breast cancer during pregnancy [Ｊ]. Cancer, 1994; 74(1)∶518.
19. Mazze RI, Kallen B. Reproductive outcome after anesthesia and operation during pregnancy： a registry study of 5 405 cases [Ｊ]. Am J Obstet Gynecol, 1989; 161(5)∶1178.
20. Gemignani ML, Petrek JA, Borgen PI. Breast cancer and pregnancy [Ｊ]. Surg Clin North Am, 1999; 79(5)∶1157.
21. Petrek JA.Breast cancer during pregnancy [Ｊ]. Cancer , 1994; 74 (1 Suppl)∶518.
22. Marchant DJ. Breast cancer in pregnancy [Ｊ]. Clin Obstet Gynecol, 1994; 37(4)∶993.
23. Hoover HC Jr. Breast cancer during pregnancy and lactation [Ｊ] .Surg Clin North Am, 1990; 70(5)∶1151.
24. Espie M, Cuvier C. Treating breast cancer during pregnancy. What can be taken safely? [Ｊ]. Drug Saf, 1998; 18(2)∶135.
25. Espie M, Cuvier C.Treatment of breast cancer during pregnancy [Ｊ]. Contracept Fertil Sex, 1996; 24(11)∶805.
26. Nugent P,O’Connell TX.Breast cancer and pregnancy [Ｊ]. Arch Surg, 1985； 120(11)∶1221.
27. Malamos NA,Stathopoulos GP,Keramopoulos A, et al.Pregnancy and offspring after the appearance of breast cancer [Ｊ]. Oncology, 1996; 53(6)∶ 471.
28. Collichio FA, Agnello R, Staltzer J. Pregnancy after breast cancer: from psychosocial issues through conception [Ｊ]. Oncology (Huntingt), 1998； 12(5)∶759.
29. Ariel IM, Kempner R. The prognosis of patients who become pregnant after mastectomy for breast cancer [Ｊ]. Int Surg, 1989; 74(3)∶185.
30. Petrek JA. Pregnancy safety after breast cancer [Ｊ]. Cancer, 1994; 74(1 Suppl)∶528.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Breast Cancer During Pregnancy

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