Research Advance of Relationship Between RET Proto-Oncogene and Differentiated Thyroid Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

TANG Bo , JIANG Jun

Department of General Surgery, Southwest Hospital, Chongqing 400038， China;

Corresponding author：

Keywords：

RET gene; Thyroid carcinoma

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Objective To review recent studies on the research advance of the relationship between RET proto-oncogene and differentiated thyroid carcinoma.
Methods The literatures in recent years on the structure of RET gene and coding product,cell signal transduction,relationship between RET proto-oncogene and differentiated thyroid carcinoma were reviewed.
Results RET gene encoding tyrosine kinase receptor,involving in cell signal transduction,rearrangement of RET gene was frequently seen in papillary thyroid carcinoma.
Conclusion Rearrangement of RET gene was closely correlated with the occurrence and progress of differentiated thyroid carcinoma,RET gene may be considered as a new therapeutic target for differentiated thyroid carcinoma.

Citation： TANG Bo,JIANG Jun. Research Advance of Relationship Between RET Proto-Oncogene and Differentiated Thyroid Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(1): 89-91. doi: Copy

1.	Takahashi M， Ritz J， Cooper GM. Activation of a novel human transforming gene, ret, by DNA rearrangement [J]. Cell, 1985; 42(2)∶581.
2.	Pasini B, Hofstra RM, Yin L,et al.The physical map of the human RET protooncogene [J]. Oncogene, 1995; 11(9)∶1737.
3.	Durbec P, MarcosGutierrez CV, Kilkenny, et al.GDNF signalling through the Ret receptor tyrosine kinase [J]. Nature, 1996; 381(6585)∶789.
4.	Besset V, Scott RP, Ibanez CF.Signaling complexes and proteinprotein interactions involved in the activation of the Ras and phosphatidylinositol 3kinase pathways by the cRet receptor tyrosine kinase [J]. J Biol Chem, 2000; 275(50)∶39159.
5.	De Vita G, Melillo RM, Carlomagno F, et al. Tyrosine 1062 RETMEN2A mediates activation of Akt (protein kinase B) and mitogenactivated protein kinase pathways leading to PC12 cell survival [J]. Cancer Res, 2000; 60(14)∶3727.
6.	Hayashi H, Ichihara M, Iwashita T, et al. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell linederived neurotrophic factor [J]. Oncogene, 2000; 19(39)∶4469.
7.	Alberti L, Borrello MG, Ghizzoni S, et al.Grb2 binding to the different isoforms of Ret tyrosine kinase [J]. Oncogene, 1998; 17(9)∶1079.
8.	Arighi E, Alberti L, Torriti F, et al. Identification of Shc docking site on Ret tyrosine kinase [J]. Oncogene, 1997; 14(7)∶773.
9.	Mercalli E, Ghizzoni S, Arighi E, et al.Key role of shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein [J]. Oncogene, 2001; 20(27)∶3475.
10.	Musholt TJ, Musholt PB, Khaladj N, et al.Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma [J]. Surgery, 2000; 128(6)∶984.
11.	Roque L, Nunes VM, Ribeiro C, et al.Karyotypic charaterization of papillary thyroid carcinoma [J]. Cancer, 2001; 92(10)∶2529.
12.	Rabes HM.Gene rearrangements in radiationinduced thyroid carcinogenesis [J]. Med Pediatr Oncol, 2001; 36(5)∶574.
13.	Sheils OM, O’leary JJ, Sweeney EC, et al.Assessment of ret/PTC1 rearrange ments in neoplastic thyroid tissue using TaqMan RTPCR [J]. J Pathol， 2000; 192(1)∶32.
14.	Mai KT, Vaccani JP, Thomas J, et al. Immunostaining for ret oncogene proteins in papillary thyroid carcinoma: a correlation of ret immunoreactivity and potential of lymph node metastasis [J]. Thyroid, 2001; 11(9)∶859.
15.	Basolo F, Molinaro E, Agate L， et al.RET protein expression has no prognostic impact on the longterm outcome of papillary thyroid carcinoma [J]. Eur J Endocrinol, 2001; 145(5)∶599.
16.	Salvatore G, Nagata S, Billaud M, et al. Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase [J]. Biochem Biophys Res Commun, 2002； 294(4)∶813.
17.	Hennige AM, Lammers R, Hoppner W, et al.Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1 [J]. Endocrinology, 2001; 142(10)∶4441.
18.	Carlomagno F, Vitagliano D, Guida T, et al.The kinase inhibitor PP1 blocks tumor igenesis induced by RET oncogenes [J].Cancer Res, 2002; 62(4)∶1077.

1. Takahashi M， Ritz J， Cooper GM. Activation of a novel human transforming gene, ret, by DNA rearrangement [J]. Cell, 1985; 42(2)∶581.
2. Pasini B, Hofstra RM, Yin L,et al.The physical map of the human RET protooncogene [J]. Oncogene, 1995; 11(9)∶1737.
3. Durbec P, MarcosGutierrez CV, Kilkenny, et al.GDNF signalling through the Ret receptor tyrosine kinase [J]. Nature, 1996; 381(6585)∶789.
4. Besset V, Scott RP, Ibanez CF.Signaling complexes and proteinprotein interactions involved in the activation of the Ras and phosphatidylinositol 3kinase pathways by the cRet receptor tyrosine kinase [J]. J Biol Chem, 2000; 275(50)∶39159.
5. De Vita G, Melillo RM, Carlomagno F, et al. Tyrosine 1062 RETMEN2A mediates activation of Akt (protein kinase B) and mitogenactivated protein kinase pathways leading to PC12 cell survival [J]. Cancer Res, 2000; 60(14)∶3727.
6. Hayashi H, Ichihara M, Iwashita T, et al. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell linederived neurotrophic factor [J]. Oncogene, 2000; 19(39)∶4469.
7. Alberti L, Borrello MG, Ghizzoni S, et al.Grb2 binding to the different isoforms of Ret tyrosine kinase [J]. Oncogene, 1998; 17(9)∶1079.
8. Arighi E, Alberti L, Torriti F, et al. Identification of Shc docking site on Ret tyrosine kinase [J]. Oncogene, 1997; 14(7)∶773.
9. Mercalli E, Ghizzoni S, Arighi E, et al.Key role of shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein [J]. Oncogene, 2001; 20(27)∶3475.
10. Musholt TJ, Musholt PB, Khaladj N, et al.Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma [J]. Surgery, 2000; 128(6)∶984.
11. Roque L, Nunes VM, Ribeiro C, et al.Karyotypic charaterization of papillary thyroid carcinoma [J]. Cancer, 2001; 92(10)∶2529.
12. Rabes HM.Gene rearrangements in radiationinduced thyroid carcinogenesis [J]. Med Pediatr Oncol, 2001; 36(5)∶574.
13. Sheils OM, O’leary JJ, Sweeney EC, et al.Assessment of ret/PTC1 rearrange ments in neoplastic thyroid tissue using TaqMan RTPCR [J]. J Pathol， 2000; 192(1)∶32.
14. Mai KT, Vaccani JP, Thomas J, et al. Immunostaining for ret oncogene proteins in papillary thyroid carcinoma: a correlation of ret immunoreactivity and potential of lymph node metastasis [J]. Thyroid, 2001; 11(9)∶859.
15. Basolo F, Molinaro E, Agate L， et al.RET protein expression has no prognostic impact on the longterm outcome of papillary thyroid carcinoma [J]. Eur J Endocrinol, 2001; 145(5)∶599.
16. Salvatore G, Nagata S, Billaud M, et al. Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase [J]. Biochem Biophys Res Commun, 2002； 294(4)∶813.
17. Hennige AM, Lammers R, Hoppner W, et al.Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1 [J]. Endocrinology, 2001; 142(10)∶4441.
18. Carlomagno F, Vitagliano D, Guida T, et al.The kinase inhibitor PP1 blocks tumor igenesis induced by RET oncogenes [J].Cancer Res, 2002; 62(4)∶1077.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Advance of Relationship Between RET Proto-Oncogene and Differentiated Thyroid Carcinoma

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