Objective To study the expression of nuclear factor-κBp65 (NF-κBp65) in gastric carcinoma and its relationship with vascular endothelial growth factor (VEGF).
Methods The expression of NF-κBp65 and VEGF in 56 gastric carcinomas was detected with immunohistochemistry and compared with benign tissues.
Results The positive rates of NF-κBp65 and VEGF in 56 gastric carcinomas were 62.5% and 76.8% respectively,and which were higher than those of gastric mucosal atypical hyperplasia (33.3% and 44.4%) and the normal gastric mucosa(0 and 8.3%) （P＜0.05,P＜0.01）.It was found that there was relationship between the expression of NF-κBp65 and the clinical stage, invasion depth of tumor and lymph node metastasis (P＜0.05),but there was no relation to the historica type (P gt;0.05). There was positive correlation between NF-κBp65 and VEGF expression （r=0.36,P＜0.01）.
Conclusion NF-κBp65 may play an important role in the development of gastric carcinoma by up-regulate the expression of VEGF.
Citation：
SHI Zhaohui,CHANG Xinzhong,JIANG Xihong,LI Zhaoting. Expression of Nuclear Factor-Kappa B p65 in Gastric Carcinoma and Its Relationship with Vascular Endothelial Growth Factor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(2): 113-115. doi:
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- 1. 曾益新主编. 肿瘤学 [M]. 第1版. 北京： 人民卫生出版社, 1999∶187～188.
- 2. 郭双平,翟宇强,王文亮. 核转录因子κB在肾细胞癌中的表达及意义 [Ｊ]. 诊断病理学杂志， 2002； 9(2)∶96.
- 3. 刘立龙， 石琳， 高丽丽. 胃癌VEGF和nm23表达与血管生成的关系及其临床意义 [Ｊ]. 实用肿瘤杂志， 2000； 15（5）∶312.
- 4. 钟霞. NFκB的活化与肿瘤的研究进展 [Ｊ]. 医学理论与实践, 2001; 14(11)∶1102.
- 5. Wang W, Abbruzzese JL, Evans DB, et al. The nuclear factorkappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells [Ｊ]. Clin Cancer Res, 1999; 5(1)∶119.
- 6. Huang S, Pettaway CA, Uehara H, et al. Blockade of NFkappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis [Ｊ]. Oncogene, 2001; 20(31)∶4188.
- 7. 王维，罗和生，余保平. 人胃癌及癌前病变中NFkappaB和cmyc蛋白的表达与意义 [Ｊ]. 肿瘤防治研究, 2002; 29(4)∶285.
- 8. 李磊，李继昌，王继恒. VEGF和MMP在胃癌中的表达及其在浸润转移中的作用 [Ｊ]. 河南肿瘤学杂志， 2002; 15(4)∶242.
- 9. Shibata A, Nagaya T, Imai T, et al. Inhibition of NFkappaB activity decreases the VEGF mRNA expression in MDAMB231 breast cancer cells [Ｊ]. Breast Cancer Res Treat, 2002; 73(3)∶237.
