Vascular Elasticity in Patients with Spontaneous Rupture of Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZOU Bingbing ¹ , GENG Xiaoping ¹ , ZHU Lixin ¹ , XIONG Qiru ¹ , FAN Shangda ²

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;

Corresponding author：

Keywords：

Hepatocellular carcinoma; Rupture; von Willebrand factor; Elastin; Elastase

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Objective To investigate the relationship between changes of vascular elasticity and spontaneous rupture of hepatocellular carcinoma (HCC).
Methods We examined the semiquantitatively expression of related angiogenesis factors including von Willebrand factor, elastin and neutrophil elastase in 30 specimens of HCC with spontaneous rupture by immunohistochemistry compared with 30 specimens of HCC without rupture.
Results The results showed that there was a significant decrease of von Willebrand factor, overproliferation of elastin and abnormal distribution of neutrophil elastase around the small artery in ruptured HCC. These changes exacerbated weakness of the blood vessels and destroyed function of coagulation. The blood vessels split easily when the vascular load increased from hypertension or minor mechanical trauma.
Conclusion The spontaneous rupture of HCC may be related to the vascular dysfunction.

Citation： ZOU Bingbing,GENG Xiaoping,ZHU Lixin,XIONG Qiru,FAN Shangda. Vascular Elasticity in Patients with Spontaneous Rupture of Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(2): 154-156. doi: Copy

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1. Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases [J]. Am J Gastroenterol， 1991; 86(1)∶67.
2. Ong GB, Chu EP, Yu FY, et al. Spontaneous rupture of hepatocellular carcinoma [Ｊ]. Br J Surg， 1965; 52∶123.
3. Chearanai O, Plengvanit U, Asavanich C, et al. Spontaneous rupture of primary hepatoma: report of 63 cases with particular reference to the pathogenesis and rationale treatment by hepatic artery ligation [Ｊ]. Cancer, 1983; 51(8)∶1532.
4. Lai EC, Wu KM, Choi TK, et al. Spontaneous ruptured hepatocellular carcinoma. An appraisal of surgical treatment [Ｊ]. Ann Surg, 1989; 210(1)∶24.
5. Kanematsu M, Imaeda T, Yamawaki Y, et al. Rupture of hepatocellular carcinoma: predictive value of CT findings [Ｊ]. AJR Am J Roentgenol, 1992; 158(6)∶1247.
6. Zhu LX, Wang GS, Fan ST. Spontaneous rupture of hepatocellular carcinoma [Ｊ]. Br J Surg, 1996; 83(5)∶602.
7. Leib ES, Hibrawi H, Chia D, et al. Correlation of disease activity in systemic necrotizing vasculitis with immune complexes [Ｊ]. J Rheumatol, 1981; 8(2)∶258.
8. Assoian RK, Sporn MB. Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells [Ｊ]. J Cell Biol, 1986; 102(4)∶1217.
9. Ross R. Plateletderived growth factor [Ｊ]. Lancet, 1989; 1(8648)∶1179.
10. Cozzolino F, Torcia M, Lucibello M, et al. Interferonalpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth [Ｊ]. J Clin Invest, 1993; 91(6)∶2504.
11. Baugh RJ, Travis J. Human leukocyte granule elastase: rapid isolation and characterization [Ｊ]. Biochemistry, 1976; 15(4)∶836.
12. Liu JM, Davidson JM. The elastogenic effect of recombinant transforming growth factorbeta on porcine aortic smooth muscle cells [Ｊ]. Biochem Biophys Res Commun, 1988; 154(3)∶895.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Vascular Elasticity in Patients with Spontaneous Rupture of Hepatocellular Carcinoma

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