Immunohistochemical Study about Expression of Caspase-3 in Hemangiomas_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Nan , CHEN Xinsheng , CHEN Daliang.

Department of General Surgery,Xiehe Hospital,Fujian Medical University,Fuzhou 350001, China;

Corresponding author：

Keywords：

Caspase-3; Hemangioma; Apoptosis

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ObjectiveTo study the relationship between expression of Caspase-3 and regression of hemangioma. MethodsCaspase-3 expression was detected in 79 hemangiomas and 5 normal skin tissues by immunohistochemistry (SP). ResultsIn 79 hemangiomas, the positive rates of Caspase-3 expression in proliferating, involuting and involuted phases were 52.4%, 91.2% and 83.3%, respectively. The expression of Caspase-3 in involuted and involuting phases was higher than proliferating phase(P lt;0.05，P lt;0.01) and control group(P lt;0.01). There was no statistical difference between the latter two groups (P gt;0.05). ConclusionCaspase3 is involved in the converting of hemangiomas from proliferating phase into involuting phase. The activation of Caspase-3 may induce apoptosis of endothelial cells, thus leading to the regression of hemagioma.

Citation： LI Nan,CHEN Xinsheng,CHEN Daliang.. Immunohistochemical Study about Expression of Caspase-3 in Hemangiomas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 311-313. doi: Copy

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1. Iwata J, Sonobe H, Furihata M, et al. High frequency of apoptosis in infantile capillary haemangioma [Ｊ]. J Pathol, 1996; 179(4)∶ 403.
2. Razon MJ, Kraling BM, Mulliken JB, et al. Increased apoptosis coincides with onset of involution in infantile hemangioma [Ｊ]. Microcirculation, 1998; 5(2-3)∶189.
3. Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies [Ｊ]. Curr Probl Surg, 2000; 37(8)∶517.
4. 卢晓晔，覃莉，黄中新，等. caspase活化的细胞凋亡在非小细胞肺癌组织中的表达 [Ｊ]. 实用癌症杂志， 2002； 17（2）∶122.
5. 中华病理学杂志编辑委员会. 《全国免疫组织化学技术与诊断标准化专题研讨会》会议记要 [Ｊ]. 中华病理学杂志， 1996； 25（6）∶326.
6. Chang HY, Yang X. Proteases for cell suicide: functions and regulation of caspases [Ｊ]. Microbiol Mol Biol Rev, 2000; 64(4)∶821.
7. Thornberry NA, Lazebnik Y. Caspases: enemies within [Ｊ]. Science, 1998; 281(5381)∶1312.
8. Woo M, Hakem R, Soengas MS, et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes [Ｊ]. Genes Dev, 1998; 12(6)∶806.
9. Horky M, Wurzer G, Kotala V, et al. Segregation of nucleolar components coincides with caspase3 activation in cisplatintreated HeLa cells [Ｊ]. Journal of Cell Science, 2000; 114(Pt 4)∶663.
10. Tan ST, Velickovic M, Ruger BM, et al. Cellular and extracellular markers of hemangioma [Ｊ]. Plast Reconstr Surg, 2000; 106(3)∶529.
11. Nakagawara A, Nakamura Y, Ikeda H, et al. High levels of expression and nuclear localization of interleukin1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas [Ｊ].Cancer Res, 1997; 57(20)∶4578.
12. Nicholson DW. From bench to clinic with apoptosisbased therapeutic agents [Ｊ]. Nature, 2000; 407(6805)∶810.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Immunohistochemical Study about Expression of Caspase-3 in Hemangiomas

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