Research Advances in Molecular Biology of Vascular Restenosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHENG Jianghua ¹ , LIU Yujuan ² , SHI De. ¹

Department of Vascular Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;

Corresponding author：

Keywords：

Molecular biology; Vascular restenosis

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ObjectiveTo review the research advances in molecular biology of vascular restenosis.MethodsThe literatures about molecular biology of vascular restenosis were reviewed.ResultsCurrent transgenic ways had some advantages and disadvantages. Gene therapy with HSV-tk, Rb,p21，p27,p53,c-myc, c-myb, vascular endothelial growth factor,bFGF,platelet derived growth facfor，nuclear factor-κB and so on inhibited vascular restenosis.ConclusionA better transgenic system and gene-combination therapy will be effective to treat vascular restenosis.

Citation： ZHENG Jianghua,LIU Yujuan,SHI De.. Research Advances in Molecular Biology of Vascular Restenosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 318-321. doi: Copy

1.	Lee JS, Adrie C, Jacob HJ, et al. Chronic inhalation of nitric oxide inhibits neointimal formation after ballooninduced arterial injury [J]. Circ Res, 1996; 78(2)∶337.
2.	Nikol S, Huehns TY, Krausz E, et al. Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation [J]. Gene Ther, 1999; 6(5)∶737.
3.	Kibbe MR, Nie S, Yoneyama T, et al. Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts [J]. Surgery, 1999; 126(2)∶323.
4.	Dichek DA, Anderson J, Kelly AB, et al. Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors [J]. Circulation, 1996; 93(2)∶301.
5.	Hanna AK, Fox JC, Neschis DG, et al. Antisense basic fibroblast growth factor gene transfer reduces neointimal thickening after arterial injury [J].J Vasc Surg, 1997; 25(2)∶320.
6.	Cioffi CL, Garay M, Johnston JF, et al. Selective inhibition of ARaf and CRaf mRNA expression by antisense oligodeoxynucleotides in rat vascular smooth muscle cells: role of ARaf and CRaf in seruminduced proliferation [J].Mol Pharmacol, 1997; 51(3)∶383.
7.	von der Leyen HE, Dzau VJ. Therapeutic potential of nitric oxide synthase gene manipulation [J].Circulation, 2001; 103(22)∶2760.
8.	Chen L, Daum G, Forough R, et al. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in ballooninjured carotid artery [J].Circ Res, 1998; 82(8)∶862.
9.	Zoldhelyi P, McNatt J, Xu XM,et al. Prevention of arterial thrombosis by adenovirusmediated transfer of cyclooxygenase gene [J]. Circulation, 1996; 93(1)∶10.
10.	Stark VK, Hoch JR, Warner TF, et al. Monocyte chemotactic protein1 expression is associated with the development of vein graft intimal hyperplasia [J]. Arterioscler Thromb Vasc Biol, 1997; 17(8)∶1614.
11.	李福生，王宗立，许漫,等. 表达反义单核细胞趋化蛋白1重组逆转录病毒对家兔动脉平滑肌单核细胞趋化蛋白1基因表达的影响 [J]. 中国动脉硬化杂志， 1999; 7（4）∶283.
12.	Ueno H, Yamamoto H, Ito S, et al. Adenovirusmediated transfer of a dominantnegative Hras suppresses neointimal formation in ballooninjured arteries in vivo [J]. Arterioscler Thromb Vasc Biol, 1997; 17(5)∶898.
13.	Gunn J, Holt CM, Francis SE, et al. The effect of oligonucleotides to cmyb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty [J]. Circ Res, 1997; 80(4)∶520.
14.	Chen SJ, Chen YF, Miller DM, et al. Mithramycin inhibits myointimal proliferation after balloon injury of the rat carotid artery in vivo [J]. Circulation, 1994; 90(5)∶2468.
15.	Qian HS, Channon K, Neplioueva V, et al. Improved adenoviral vector for vascular gene therapy: beneficial effects on vascular function and inflammation [J]. Circ Res, 2001; 88(9)∶911.
16.	Chang MW, Barr E, Lu MM, et al. Adenovirusmediated overexpression of the cyclin/cyclindependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty [J]. J Clin Invest, 1995; 96(5)∶2260.
17.	Luo Z, Sata M, Nguyen T, et al. Adenovirusmediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals [J]. Circulation, 1999; 99(14)∶1776.
18.	Chen D, Krasinski K, Sylvester A, et al. Downregulation of cyclindependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery [J]. J Clin Invest, 1997; 99(10)∶2334.
19.	Yonemitsu Y, Kaneda Y, Tanaka S, et al. Transfer of wildtype p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo [J]. Circ Res, 1998; 82(2)∶147.
20.	Scheinman M, Ascher E, Kallakuri S, et al. P53 gene transfer to the injured rat carotid artery promotes apoptosis [J]. Surgery, 1999; 126(5)∶863.
21.	Autieri MV. Expression of anaphasepromoting complex 5 in balloon angioplastyinjured rat carotid arteries and mitogenstimulated human vascular smooth muscle cells [J]. Biochem Biophys Res Commun, 2001; 282(3)∶723.
22.	Maillard L, Van Belle E, Smith RC, et al. Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty [J]. Cardiovasc Res, 1997; 35(3)∶536.
23.	Morishita R, Gibbons GH, Horiuchi M, et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo [J]. Proc Natl Acad Sci USA, 1995; 92(13)∶5855.
24.	Nabel EG, Plautz G, Boyce FM, et al. Recombinant gene expression in vivo within endothelial cells of the arterial wall [J]. Science, 1989; 244(4910)∶1342.
25.	Ohno T, Gordon D, San H, et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury [J]. Science, 1994; 265(5173)∶781.
26.	Guzman RJ, Hirschowitz EA, Brody SL, et al. In vivo suppression of injuryinduced vascular smooth muscle cell accumulation using adenovirusmediated transfer of the herpes simplex virus thymidine kinase gene [J]. Proc Natl Acad Sci USA, 1994; 91(22)∶10732.
27.	乔正荣，时德. 细胞凋亡和血管病变 [J]. 中国普外基础与临床杂志， 2001； 8（3）∶202.
28.	George SJ, Johnson JL, Angelini GD, et al. Adenovirusmediated gene transfer of the human TIMP1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein [J]. Hum Gene Ther, 1998; 9(6)∶867.
29.	Dollery CM, Humphries SE, McClelland A, et al. Expression of tissue inhibitior of matrix metalloproteinases 1 by use of an adenoviral vector inhibitors smooth muscle cell migration and reduces neointimal byperplasia in the rat model of vascular balloon injury [J]. Circulation, 1999; 99(24)∶3199.
30.	涂兵，金立人. 血管内皮细胞生长因子及有关肢体缺血基因治疗的研究进展 [J]. 中国普外基础与临床杂志， 2000； 7（3）∶202.
31.	Van Belle E, Maillard L, Tio FO, et al. Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces instent intimal formation [J]. Biochem Biophys Res Commun, 1997; 235(2)∶311.

1. Lee JS, Adrie C, Jacob HJ, et al. Chronic inhalation of nitric oxide inhibits neointimal formation after ballooninduced arterial injury [J]. Circ Res, 1996; 78(2)∶337.
2. Nikol S, Huehns TY, Krausz E, et al. Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation [J]. Gene Ther, 1999; 6(5)∶737.
3. Kibbe MR, Nie S, Yoneyama T, et al. Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts [J]. Surgery, 1999; 126(2)∶323.
4. Dichek DA, Anderson J, Kelly AB, et al. Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors [J]. Circulation, 1996; 93(2)∶301.
5. Hanna AK, Fox JC, Neschis DG, et al. Antisense basic fibroblast growth factor gene transfer reduces neointimal thickening after arterial injury [J].J Vasc Surg, 1997; 25(2)∶320.
6. Cioffi CL, Garay M, Johnston JF, et al. Selective inhibition of ARaf and CRaf mRNA expression by antisense oligodeoxynucleotides in rat vascular smooth muscle cells: role of ARaf and CRaf in seruminduced proliferation [J].Mol Pharmacol, 1997; 51(3)∶383.
7. von der Leyen HE, Dzau VJ. Therapeutic potential of nitric oxide synthase gene manipulation [J].Circulation, 2001; 103(22)∶2760.
8. Chen L, Daum G, Forough R, et al. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in ballooninjured carotid artery [J].Circ Res, 1998; 82(8)∶862.
9. Zoldhelyi P, McNatt J, Xu XM,et al. Prevention of arterial thrombosis by adenovirusmediated transfer of cyclooxygenase gene [J]. Circulation, 1996; 93(1)∶10.
10. Stark VK, Hoch JR, Warner TF, et al. Monocyte chemotactic protein1 expression is associated with the development of vein graft intimal hyperplasia [J]. Arterioscler Thromb Vasc Biol, 1997; 17(8)∶1614.
11. 李福生，王宗立，许漫,等. 表达反义单核细胞趋化蛋白1重组逆转录病毒对家兔动脉平滑肌单核细胞趋化蛋白1基因表达的影响 [J]. 中国动脉硬化杂志， 1999; 7（4）∶283.
12. Ueno H, Yamamoto H, Ito S, et al. Adenovirusmediated transfer of a dominantnegative Hras suppresses neointimal formation in ballooninjured arteries in vivo [J]. Arterioscler Thromb Vasc Biol, 1997; 17(5)∶898.
13. Gunn J, Holt CM, Francis SE, et al. The effect of oligonucleotides to cmyb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty [J]. Circ Res, 1997; 80(4)∶520.
14. Chen SJ, Chen YF, Miller DM, et al. Mithramycin inhibits myointimal proliferation after balloon injury of the rat carotid artery in vivo [J]. Circulation, 1994; 90(5)∶2468.
15. Qian HS, Channon K, Neplioueva V, et al. Improved adenoviral vector for vascular gene therapy: beneficial effects on vascular function and inflammation [J]. Circ Res, 2001; 88(9)∶911.
16. Chang MW, Barr E, Lu MM, et al. Adenovirusmediated overexpression of the cyclin/cyclindependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty [J]. J Clin Invest, 1995; 96(5)∶2260.
17. Luo Z, Sata M, Nguyen T, et al. Adenovirusmediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals [J]. Circulation, 1999; 99(14)∶1776.
18. Chen D, Krasinski K, Sylvester A, et al. Downregulation of cyclindependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery [J]. J Clin Invest, 1997; 99(10)∶2334.
19. Yonemitsu Y, Kaneda Y, Tanaka S, et al. Transfer of wildtype p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo [J]. Circ Res, 1998; 82(2)∶147.
20. Scheinman M, Ascher E, Kallakuri S, et al. P53 gene transfer to the injured rat carotid artery promotes apoptosis [J]. Surgery, 1999; 126(5)∶863.
21. Autieri MV. Expression of anaphasepromoting complex 5 in balloon angioplastyinjured rat carotid arteries and mitogenstimulated human vascular smooth muscle cells [J]. Biochem Biophys Res Commun, 2001; 282(3)∶723.
22. Maillard L, Van Belle E, Smith RC, et al. Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty [J]. Cardiovasc Res, 1997; 35(3)∶536.
23. Morishita R, Gibbons GH, Horiuchi M, et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo [J]. Proc Natl Acad Sci USA, 1995; 92(13)∶5855.
24. Nabel EG, Plautz G, Boyce FM, et al. Recombinant gene expression in vivo within endothelial cells of the arterial wall [J]. Science, 1989; 244(4910)∶1342.
25. Ohno T, Gordon D, San H, et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury [J]. Science, 1994; 265(5173)∶781.
26. Guzman RJ, Hirschowitz EA, Brody SL, et al. In vivo suppression of injuryinduced vascular smooth muscle cell accumulation using adenovirusmediated transfer of the herpes simplex virus thymidine kinase gene [J]. Proc Natl Acad Sci USA, 1994; 91(22)∶10732.
27. 乔正荣，时德. 细胞凋亡和血管病变 [J]. 中国普外基础与临床杂志， 2001； 8（3）∶202.
28. George SJ, Johnson JL, Angelini GD, et al. Adenovirusmediated gene transfer of the human TIMP1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein [J]. Hum Gene Ther, 1998; 9(6)∶867.
29. Dollery CM, Humphries SE, McClelland A, et al. Expression of tissue inhibitior of matrix metalloproteinases 1 by use of an adenoviral vector inhibitors smooth muscle cell migration and reduces neointimal byperplasia in the rat model of vascular balloon injury [J]. Circulation, 1999; 99(24)∶3199.
30. 涂兵，金立人. 血管内皮细胞生长因子及有关肢体缺血基因治疗的研究进展 [J]. 中国普外基础与临床杂志， 2000； 7（3）∶202.
31. Van Belle E, Maillard L, Tio FO, et al. Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces instent intimal formation [J]. Biochem Biophys Res Commun, 1997; 235(2)∶311.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Advances in Molecular Biology of Vascular Restenosis

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