Expression and Significance of Vascular Endothelial Growth Factor Receptor-3 in Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Tianbao ¹ , DONG Wenguang ¹ , HAN Fanghai ¹ , LI Zhaoting. ²

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yatsen University, Guangzhou 510080, China;

Corresponding author：

Keywords：

Gastric tumor; Vascular endothelial growth factor receptor-3; Lymphangiogenesis; Immunohistochemistry

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ObjectiveTo investigate the relationship between vascular endothelial growth factor receptor-3 (VEGFR-3) and clinical pathology of gastric carcinoma(GC).MethodsThe expression of VEGFR-3 in 80 GCs and 20 gastric benign tissues (GBT) was detected by immunohistochemistry(SP), by which the density of lymphatic vessels (DLV) was calculated. ResultsThe DLV in GC was （5.800 0±2.318 9）/×200, in GBT （2.380 0±0.462 9）/×200(P=0.000); in GC with lymph node metastasis （6.948 3±1.583 1）/×200, without lymph node metastasis （2.772 7±0.428 9）/×200 （P=0.000）. In poorly differentiated type group, DLV was （7.681 8±0.982 9）/×200, higher than that in moderately and highly differentiated type group 〔(3.500 0±1.028 2）/×200, P=0.000〕. DLV in pTNM Ⅰ+Ⅱ was （4.291 7±1.688 0）/×200, in Ⅲ+Ⅳ （8.062 5±0.759 4）/×200 （P=0.000）.ConclusionDLV shows positive relations with pTNM stage, differentiation and lymph node metastasis of GC.

Citation： WANG Tianbao,DONG Wenguang,HAN Fanghai,LI Zhaoting.. Expression and Significance of Vascular Endothelial Growth Factor Receptor-3 in Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 341-343. doi: Copy

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7.	董昕,邱雪杉,王恩华,等.血管内皮生长因子C及其受体3在非小细胞肺癌组织中的表达及意义 [Ｊ]. 中华病理学杂志, 2003; 32(2)∶128.
8.	于大海,温玉明,李龙江,等.口腔癌VEGFC表达和血管淋巴管生成与淋巴道转移关系的研究 [Ｊ]. 临床口腔医学杂志, 2001; 17(1)∶6.
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1. 李继坤，郑淼，李远,等. p53及VEGF表达与结、直肠癌血道转移发生的关系 [Ｊ]. 中国普外基础与临床杂志, 2002； 9(2）∶112.
2. 雷雯，郁宝铭，周锡庚. 大肠癌组织中微血管定量检测的临床价值 [Ｊ]. 中国普外基础与临床杂志， 2002； 9(1)∶40.
3. 敬静，李宏江，朱炜炜,等. 乳腺疾病中血管内皮生长因子的表达及其意义 [Ｊ]. 中国普外基础与临床杂志, 2001； 8（5）∶322.
4. Enholm B, Jussila L, Karkkainen M, et al. Vascular endothelial growth factorC; a growth factor for lymphatic and blood vascular endothelial cells [Ｊ]. Trends Cardiovasc Med, 1998; 8(7)∶292.
5. Mimura T, Amano S, Usui T, et al. Expression of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in corneal lymphangiogenesis [Ｊ]. Exp Eye Res, 2001; 72(1)∶71.
6. Kishimoto K, Sasaki A, Yoshihama Y, et al. Expression of vascular endothelial growth factorC predicts regional lymph node metastasis in early oral squamous cell carcinoma [Ｊ]. Oral Oncol, 2003; 39(4)∶391.
7. 董昕,邱雪杉,王恩华,等.血管内皮生长因子C及其受体3在非小细胞肺癌组织中的表达及意义 [Ｊ]. 中华病理学杂志, 2003; 32(2)∶128.
8. 于大海,温玉明,李龙江,等.口腔癌VEGFC表达和血管淋巴管生成与淋巴道转移关系的研究 [Ｊ]. 临床口腔医学杂志, 2001; 17(1)∶6.
9. 于大海,温玉明,王昌美,等. VEGFR3表达与口腔癌淋巴道转移的关系 [Ｊ]. 临床口腔医学杂志, 2001; 17(4)∶243.
10. Ueda M, Terai Y, Kumagai K, et al. Vascular endothelial growth factor C gene expression is closely related to invasion phenotype in gynecological tumor cells [Ｊ]. Gynecol Oncol, 2001; 82(1)∶162.
11. Yonemura Y, Fushida S, Bando E, et al. Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)3 in gastric cancer [Ｊ]. Eur J Cancer, 2001; 37(7)∶918.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Significance of Vascular Endothelial Growth Factor Receptor-3 in Gastric Carcinoma

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