Effects of Recombinant Human Growth Hormone on Pathophysiology of Critically Ill Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN Rongqing , FENG Min , DU Yuming.

The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China;

Corresponding author：

Keywords：

Recombinant human growth hormone; Multiple organ dysfunction syndrome

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ObjectiveTo investigate the role of recombinant human growth hormone (rhGH) in the treatment of patients with multiple organ dysfunction syndrome (MODS). MethodsThirty-eight patients with MODS routinely treated with antibiotics and nutrition support were divided into two groups: the rhGH group and control group. The rhGH group was treated by subcutaneous injection of 5 U rhGH for two weeks. ResultsOn the 7th day of treatment, the score of APACHE Ⅱ in the rhGH group was much higher than the control group, the levels of ALT, AST, BUN and Cre did not change much compared with the control group. The level of albumin in the rhGH group increased (P＜0.05). The stay in ICU, time of mechanical ventilation and hospital stay decreased compared with the control group (P＜0.05). ConclusionrhGH can effectively improve the pathophysiology of critically ill patients and has no side effects on the function of liver and kidney, meanwhile it can shorten hospital stay and decrease mortality.

Citation： SUN Rongqing,FENG Min,DU Yuming.. Effects of Recombinant Human Growth Hormone on Pathophysiology of Critically Ill Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(4): 344-346. doi: Copy

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1. Assy N, Hochberg Z, Enat R, et al. Prognostic value of generation of growth hormonestimulated insulinlike growth factorI (IGFI) and its binding protein3 in patients with compensated and decompensated liver cirrhosis [Ｊ]. Dig Dis Sci, 1998; 43(6)∶1317.
2. 周国雄，李兆申. 重组人生长激素治疗慢性肝病和肝硬化的研究进展 [A]. 吴云林主编. 胃肠病学临床进展 [M]. 上海：上海科学文献技术出版社， 1999∶81～86.
3. VaraThorbeck R, RuizRequena E, GuerreroFernandez JA. Effects of human growth hormone on the catabolic state after surgical trauma [Ｊ]. Horm Res, 1996; 45(1-2)∶55.
4. Olney RC. Regulation of bone mass by growth hormone [Ｊ]. Med Pediatr Oncol, 2003; 41(3)∶228.
5. Darmaun D, Hayes V, Schaeffer D, et al. Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis [Ｊ]. J Clin Endocrinol Metab, 2004; 89(3)∶1146.
6. Liang Z, Liu X, Li J, et al. The effects of recombinant human growth hormone (rhGH) on the serum levels of cytokines in severely burned patients [Ｊ]. Zhonghua Shao Shang Za Zhi, 2002; 18(1)∶49.
7. Adamopoulos S, Parissis JT, Paraskevaidis I, et al. Effects of growth hormone on circulating cytokine network, and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathy [Ｊ]. Eur Heart J, 2003; 24(24)∶2186.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Recombinant Human Growth Hormone on Pathophysiology of Critically Ill Patients

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