Cytomegalovirus Infection after Liver Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PENG Yong ¹ , GONG Jianping ¹ , YAN Lnan. ²

Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China;

Corresponding author：

Keywords：

Liver transplantation Cytomegalovirus infection

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】Objective To study the characteristics, diagnosis, treatment and prophylaxis of cytomegalovirus (CMV) infection after liver transplantation.
Methods The literatures of recent 10 years were collected and reviewed.
Results The infection rate of CMV after liver transplantation was high, and it was frequently complicated with other types of infectious diseases. There was no specificity in the clinical features of CMV infection, and no effective measures were taken for early diagnosis, prevention and therapy.
Conclusion CMV is the primary opportunistic pathogen after liver transplantation. Monitoring the status of CMV infection in recipients preoperatively and postoperatively, early prophylaxis and treatment are very important and useful to prevent and treat this disease.

Citation： PENG Yong,GONG Jianping,YAN Lnan.. Cytomegalovirus Infection after Liver Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2004, 11(5): 409-412. doi: Copy

1.	Sarcinella L, Mazzulli T, Willey B, et al. Cytomegalovirus glycoprotein B genotype does not correlate with outcomes in liver transplant patients [J]. J Clin Virol, 2002; 24(1-2)∶99.
2.	Turgeon N, Fishman JA, Doran M, et al. Prevention of recurrent cytomegalovirus disease in renal and liver transplant recipients: effect of oral ganciclovir [J]. Transpl Infect Dis, 2000; 2(1)∶2.
3.	Falagas ME, Snydman DR, Ruthazer R, et al. Primary cytomegalovirus infection in liver transplant recipients: comparison of infections transmitted via donor organs and via transfusions. Boston Center for Liver Transplantation CMVIG Study Group [J]. Clin Infect Dis, 1996; 23(2)∶292.
4.	Portela D, Patel R, LarsonKeller JJ, et al. OKT3 treatment for allograft rejection is a risk factor for cytomegalovirus disease in liver transplantation [J]. J Infect Dis, 1995; 171(4)∶1014.
5.	Mutimer DJ, Shaw J, O’Donnell K, et al. Enhanced (cytomegalovirus) viral replication after transplantation for fulminant hepatic failure [J]. Liver Transpl Surg, 1997; 3(5)∶506.
6.	Paterson DL, Staplefeldt WH, Wagener MM, et al. Intraoperative hypothermia is an independent risk factor for early cytomegalovirus infection in liver transplant recipients [J]. Transplantation, 1999; 67(8)∶1151.
7.	Everson GT, Kam I. Liver transplantation: current status and unresolved controversies [J]. Adv Intern Med, 1997; 42∶505.
8.	Satou J, Funato T, Satoh N, et al. Quantitative PCR determination of human cytomegalovirus in blood cells [J]. J Clin Lab Anal, 2001; 15(3)∶122.
9.	Piiparinen H, Hockerstedt K, Lappalainen M, et al. Monitoring of viral load by quantitative plasma PCR during active cytomegalovirus infection of individual liver transplant patients [J]. J Clin Microbiol, 2002; 40(8)∶2945.
10.	Mendez JC, Espy MJ, Smith TF, et al. Evaluation of PCR primers for early diagnosis of cytomegalovirus infection following liver transplantation [J]. J Clin Microbiol, 1998; 36(2)∶526.
11.	Niubo J, Perez JL, MartinezLacasa JT, et al. Association of quantitative cytomegalovirus antigenemia with symptomatic infection in solid organ transplant patients [J]. Diagn Microbiol Infect Dis, 1996; 24(1)∶19.
12.	Kusne S, Grossi P, Irish W, et al. Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: a cost effective strategy for prevention of cytomegalovirus disease in adult liver transplant recipients [J]. Transplantation, 1999; 68(8)∶1125.
13.	Singhal S, Shaw JC, Ainsworth J, et al. Direct visualization and quantitation of cytomegalovirusspecific CD8+ cytotoxic Tlymphocytes in liver transplant patients [J]. Transplantation, 2000; 69(11)∶2251.
14.	Benz C, Utermohlen O, Wulf A, et al. Activated virusspecific T cells are early indicators of antiCMV immune reactions in liver transplant patients [J]. Gastroenterology, 2002; 122(5)∶1201.
15.	Dockrell DH, Prada J, Jones MF, et al. Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease [J]. J Infect Dis, 1997; 176(5)∶1135.
16.	Lautenschlager I, Hockerstedt K, Jalanko H, et al. Persistent cytomegalovirus in liver allografts with chronic rejection [J]. Hepatology, 1997; 25(1)∶190.
17.	van den Berg AP, Klompmaker IJ, Haagsma EB, et al. Evidence for an increased rate of bacterial infections in liver transplant patients with cytomegalovirus infection [J]. Clin Transplant, 1996; 10(2)∶224.
18.	Gavalda J, de Otero J, Murio E, et al. Two grams daily of oral acyclovir reduces the incidence of cytomegalovirus disease in CMVseropositive liver transplant recipients [J]. Transpl Int, 1997; 10(6)∶462.
19.	Winston DJ, Wirin D, Shaked A, et al. Randomised comparison of ganciclovir and highdose acyclovir for longterm cytomegalovirus prophylaxis in livertransplant recipients [J]. Lancet, 1995; 346(8967)∶69.
20.	Badley AD, Seaberg EC, Porayko MK, et al. Prophylaxis of cytomegalovirus infection in liver transplantation: a randomized trial comparing a combination of ganciclovir and acyclovir to acyclovir. NIDDK Liver Transplantation Database [J]. Transplantation, 1997; 64(1)∶66.
21.	Kanj SS, Sharara AI, Clavien PA, et al. Cytomegalovirus infection following liver transplantation: review of the literature [J]. Clin Infect Dis,,1996; 22(3)∶537.
22.	Tarp BD, Astrup LB. Should recurrent cytomegalovirus infections in patients with liver transplantation be treated? [J]. Ugeskr Laeger, 1997; 159(22)∶3413.

1. Sarcinella L, Mazzulli T, Willey B, et al. Cytomegalovirus glycoprotein B genotype does not correlate with outcomes in liver transplant patients [J]. J Clin Virol, 2002; 24(1-2)∶99.
2. Turgeon N, Fishman JA, Doran M, et al. Prevention of recurrent cytomegalovirus disease in renal and liver transplant recipients: effect of oral ganciclovir [J]. Transpl Infect Dis, 2000; 2(1)∶2.
3. Falagas ME, Snydman DR, Ruthazer R, et al. Primary cytomegalovirus infection in liver transplant recipients: comparison of infections transmitted via donor organs and via transfusions. Boston Center for Liver Transplantation CMVIG Study Group [J]. Clin Infect Dis, 1996; 23(2)∶292.
4. Portela D, Patel R, LarsonKeller JJ, et al. OKT3 treatment for allograft rejection is a risk factor for cytomegalovirus disease in liver transplantation [J]. J Infect Dis, 1995; 171(4)∶1014.
5. Mutimer DJ, Shaw J, O’Donnell K, et al. Enhanced (cytomegalovirus) viral replication after transplantation for fulminant hepatic failure [J]. Liver Transpl Surg, 1997; 3(5)∶506.
6. Paterson DL, Staplefeldt WH, Wagener MM, et al. Intraoperative hypothermia is an independent risk factor for early cytomegalovirus infection in liver transplant recipients [J]. Transplantation, 1999; 67(8)∶1151.
7. Everson GT, Kam I. Liver transplantation: current status and unresolved controversies [J]. Adv Intern Med, 1997; 42∶505.
8. Satou J, Funato T, Satoh N, et al. Quantitative PCR determination of human cytomegalovirus in blood cells [J]. J Clin Lab Anal, 2001; 15(3)∶122.
9. Piiparinen H, Hockerstedt K, Lappalainen M, et al. Monitoring of viral load by quantitative plasma PCR during active cytomegalovirus infection of individual liver transplant patients [J]. J Clin Microbiol, 2002; 40(8)∶2945.
10. Mendez JC, Espy MJ, Smith TF, et al. Evaluation of PCR primers for early diagnosis of cytomegalovirus infection following liver transplantation [J]. J Clin Microbiol, 1998; 36(2)∶526.
11. Niubo J, Perez JL, MartinezLacasa JT, et al. Association of quantitative cytomegalovirus antigenemia with symptomatic infection in solid organ transplant patients [J]. Diagn Microbiol Infect Dis, 1996; 24(1)∶19.
12. Kusne S, Grossi P, Irish W, et al. Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: a cost effective strategy for prevention of cytomegalovirus disease in adult liver transplant recipients [J]. Transplantation, 1999; 68(8)∶1125.
13. Singhal S, Shaw JC, Ainsworth J, et al. Direct visualization and quantitation of cytomegalovirusspecific CD8+ cytotoxic Tlymphocytes in liver transplant patients [J]. Transplantation, 2000; 69(11)∶2251.
14. Benz C, Utermohlen O, Wulf A, et al. Activated virusspecific T cells are early indicators of antiCMV immune reactions in liver transplant patients [J]. Gastroenterology, 2002; 122(5)∶1201.
15. Dockrell DH, Prada J, Jones MF, et al. Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease [J]. J Infect Dis, 1997; 176(5)∶1135.
16. Lautenschlager I, Hockerstedt K, Jalanko H, et al. Persistent cytomegalovirus in liver allografts with chronic rejection [J]. Hepatology, 1997; 25(1)∶190.
17. van den Berg AP, Klompmaker IJ, Haagsma EB, et al. Evidence for an increased rate of bacterial infections in liver transplant patients with cytomegalovirus infection [J]. Clin Transplant, 1996; 10(2)∶224.
18. Gavalda J, de Otero J, Murio E, et al. Two grams daily of oral acyclovir reduces the incidence of cytomegalovirus disease in CMVseropositive liver transplant recipients [J]. Transpl Int, 1997; 10(6)∶462.
19. Winston DJ, Wirin D, Shaked A, et al. Randomised comparison of ganciclovir and highdose acyclovir for longterm cytomegalovirus prophylaxis in livertransplant recipients [J]. Lancet, 1995; 346(8967)∶69.
20. Badley AD, Seaberg EC, Porayko MK, et al. Prophylaxis of cytomegalovirus infection in liver transplantation: a randomized trial comparing a combination of ganciclovir and acyclovir to acyclovir. NIDDK Liver Transplantation Database [J]. Transplantation, 1997; 64(1)∶66.
21. Kanj SS, Sharara AI, Clavien PA, et al. Cytomegalovirus infection following liver transplantation: review of the literature [J]. Clin Infect Dis,,1996; 22(3)∶537.
22. Tarp BD, Astrup LB. Should recurrent cytomegalovirus infections in patients with liver transplantation be treated? [J]. Ugeskr Laeger, 1997; 159(22)∶3413.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Cytomegalovirus Infection after Liver Transplantation

Abstract Full text Figures/Tables Video References Cited by

Format

Content