Tansplantation of Pancreas and Islet: State of the Art_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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徐泽宽 , 苗毅

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Keywords：

移植; 胰腺; 胰岛

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糖尿病是临床常见病，据推测至2010年全球糖尿病患者预计将超过3.5亿，其中5%～10%的患者将因糖尿病晚期出现的糖尿病肾病、视网膜病变、微血管病变和神经末梢病变等并发症而直接影响生命，因此糖尿病及其并发症作为一项重要而艰巨的课题仍然困扰着广大医务工作者。胰腺移植和胰岛移植能增加患者胰岛素分泌细胞，从而有效地控制血糖，防止和改善糖尿病的并发症，提高生活质量，是治疗胰岛素依赖性糖尿病（IDDM）的有效手段。

Citation： 徐泽宽,苗毅. Tansplantation of Pancreas and Islet: State of the Art. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 532-534. doi: Copy

1.	Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
2.	Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
3.	Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
4.	Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
5.	West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
6.	Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
7.	Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
8.	Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
9.	Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
10.	Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
11.	Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
12.	Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
13.	Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
14.	Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
15.	Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
16.	Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
17.	Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
18.	BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
19.	Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
20.	Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.

1. Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
2. Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
3. Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
4. Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
5. West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
6. Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
7. Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
8. Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
9. Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
10. Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
11. Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
12. Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
13. Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
14. Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
15. Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
16. Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
17. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
18. BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
19. Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
20. Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Tansplantation of Pancreas and Islet: State of the Art

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