Expression of Tumor Necrosis Factor Related Apoptosis Inducing Ligand Receptor-4 in Human Pancreatic Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIAO Quan , GUO Junchao , ZHAO Yupei

Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China;

Corresponding author：

Keywords：

Pancreatic cancer; Tumor necrosis factor related apoptosis inducing ligand receptor-4; Cell apoptosis

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Objective To investigate the mechanism of the resistance of pancreatic cancer cells to tumor necrosis factor related apoptosis inducing ligand (TRAIL)mediated apoptosis. MethodsThe expression of TRAIL receptor-4 (TRAIL-R4) in normal pancreas tissue and pancreatic cancer was analyzed by using Northern blotting, Western blotting and immunohistochemistry.ResultsTRAIL-R4 mRNA and protein were expressed at moderate to high levels in human pancreatic cancer, but demonstrated weak to negative in the normal pancreas. Moreover, pancreatic cancer cells showed b TRAIL-R4 immunostaining throughout the tumor mass. Conclusion TRAIL-R4 levels are significantly different in pancreatic cancer in comparison to the normal pancreas. These findings give new insights into the resistance mechanisms of pancreatic cancer cells towards TRAILmediated apoptosis.

Citation： LIAO Quan,GUO Junchao,ZHAO Yupei. Expression of Tumor Necrosis Factor Related Apoptosis Inducing Ligand Receptor-4 in Human Pancreatic Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 535-538. doi: Copy

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1. Brammer R, Buckels J, Bramhall S. Advances in nonoperative therapy in pancreatic cancer [Ｊ]. Int J Clin Pract, 2000; 54(6)∶373.
2. Ozawa F, Friess H, Kleeff J, et al. Effects and expression of TRAIL and its apoptosispromoting receptors in human pancreatic cancer [Ｊ]. Cancer Lett, 2001; 163(1)∶71.
3. Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factorrelated apoptosisinducing ligand in vivo [Ｊ]. Nat Med, 1999; 5(2)∶157.
4. Pan G, Ni J, Yu GL, et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signaling [Ｊ]. FEBS Letter, 1998; 424(1)∶41.
5. DegliEsposti MA, Dougall WC, Smolak PJ, et al. The novel receptor TRAILR4 induces NFκB and protects against TRAILmediated apoptosis, yet retains an incomplete death domain [Ｊ]. Immunity, 1997; 7(4)∶813.
6. Zhang XD, Franco AV, Nguyen T, et al. Differential localization and regulation of death and decoy receptors for TNFrelated apoptosisinducing ligand (TRAIL) in human melanoma cells [Ｊ]. J Immunol, 2000; 164(8)∶3961.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Tumor Necrosis Factor Related Apoptosis Inducing Ligand Receptor-4 in Human Pancreatic Cancer

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