Study of Liver Volume Measurement and Its Clinical Significance in Cirrhotic Patients with Portal Hypertension_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ANG Maochun , LENG Xisheng , PENG Jirun , ZHU Jiye , DU Ruyu

Center of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China;

Corresponding author：

Keywords：

Liver cirrhosis; Portal hypertension; Liver volume; Measurement

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Objective To study the value of the clinical application of stereography and measurement of liver volume in cirrhotic patients with portal hypertension. Methods By use of the personal computer and the software of threedimensional reconstruction and measurement system of liver faultage photograph, the liver volume in vivo was successfully measured and the threedimensional image of the liver rebuilt in 46 posthepatitic cirrhotics who were selected for orthotopic liver transplantation and in 30 noncirrhotic controls, and comparison with the reference volume of recipient liver was obtained by means of water deplacement after transplantation. Results The liver volume of cirrhotic patients with portal hypertension measured by software and water deplacement was (983.33±206.11) cm3, and (904.93±209.56) cm3 respectively. Comparison by means of linear regression analysis between volume measurement on threedimensional reconstruction software and reference volume showed a nearly ideal correlation coefficient(r=0.969,P＜0.01), the average error was 8.66%.The average of liver volume in controls was (1287.00±96.18) cm3, and was positively correlated to the height，weight and body surface area (r=0.845,0.833,0.932 respectively,P＜0.01)，and was different from that of cirrhotics. Liver volume of cirrhoitic patients with portal hypertension was related to their ChildPugh classification. The liver volume of patients in Child C group was significantly smaller than that of patients of Child B group, and was significantly correlated with Alb （r=0.496, P＜0.01） and TBIL（r=-0.493, P＜0.01）,PT(r=-0.517, P＜0.01), but was not significantly correlated with ALT（r=0.206，P gt;0.05）,portal pressure（r=-0.093，P=0.539） and portosystemic shunt index (r=0.044，P=0.769). Conclusion The volume measurement of the liver by the threedimensional software is relatively accurate. Liver volume of cirrhotic patients with portal hypertension was significantly related to their liver function,and can reflect the liver reserve function.

Citation： ANG Maochun,LENG Xisheng,PENG Jirun,ZHU Jiye,DU Ruyu. Study of Liver Volume Measurement and Its Clinical Significance in Cirrhotic Patients with Portal Hypertension. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 586-588. doi: Copy

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12.	Fritschy P, Robotti G, Schneekloth G, et al. Measurement of liver volume by ultrasound and computed tomography [J]. J Clin Ultrasound, 1983; 11(6)∶299.

1. Adler M, Van Laethem J, Glibert A, et al. Factors influencing survival at one year in patients with nonbiliary hepatic parenchymal cirrhosis [J].Dig Dis Sci, 1990; 35(1)∶1.
2. Albers I,Hartmann H, Bircher J, et al. Superiority of the ChildPugh classification to quantitative liver function tests for assessing prognosis in liver cirrhosis [J].Scand J Gastroenterol, 1989; 24(3)∶269.
3. Galambos JT. Evaluation of patients with portal hypertension [J].Am J Surg, 1990; 160(1)∶14.
4. Zoli M, Cordiani MR, Marchesini G, et al. Prognostic indicators in compensated cirrhosis [J].Am J Gastroenterol, 1991; 86(10)∶1508.
5. 胡永梅，武晓洛，胡志红，等. 关于中国人体表面积公式的研究 [J].生理学报， 1999; 92(1)∶45.
6. Redvanly RD, Nelson RC, Stieber AC, et al. Imaging in the preoperative evaluation of adult livertransplant candidates: goals,merits of various procedures, and recommendations [J].AJR Am J Roentgenol, 1995; 164(3)∶611.
7. Ogasawara K, Une Y, Nakajima Y, et al. The significance of measurring liver volume using computed tomographic images before and after hepatectomy [J].Surg Today, 1995; 25(1)∶43.
8. Ros PR, Elrahman MM, Barreda R, et al.Threedimensional imaging of liver masses: preliminary experience [J]. Appl Radiol, 1990; 19(1)∶28.
9. Heymsfield SB, Fuleonwider T, Nordlinger B, et al. Accurate measurement of liver, kidney and spleen volume and mass by computerized axial tomography [J].Ann Intern Med, 1979; 90(2)∶185.
10. Van Thiel DH, Hagler NG, Schade RR, et al.In vivo hepatic volume determination using sonography and computed tomography [J].Gastroenterology, 1985; 88(6)∶1812.
11. Caldwell SH, de Lange EE, Gaffey MJ, et al. Accuracy and significance of pretransplant liver volume measured by magnetic resonance imaging [J]. Liver Transpl Surg, 1996; 2(6)∶438.
12. Fritschy P, Robotti G, Schneekloth G, et al. Measurement of liver volume by ultrasound and computed tomography [J]. J Clin Ultrasound, 1983; 11(6)∶299.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study of Liver Volume Measurement and Its Clinical Significance in Cirrhotic Patients with Portal Hypertension

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