Clinical Observation of Ulinastatin for the Treatment Multiple Injuries_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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赵英萍 ¹ , 李超 ² , 廖琼 ³ , 张爽 ¹

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Keywords：

多发伤; 乌司他丁; 细胞因子

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目的观察乌司他丁对多发伤患者的治疗作用和对肝、肾功能的保护作用。
方法 46例多发伤患者随机分为治疗组（23例）和对照组（23例）。治疗组从入院第1天开始，每天静脉点滴乌司他丁10万单位+生理盐水100 ml，每8 h 1次，连续用药6 d，观察患者的临床指标判断疗效，并在入院时以及术后第1、3、5、7天检测谷丙转氨酶（ALT）、谷草转氨酶（AST）、血尿素氮（BUN）、血肌酐（Scr）、血浆肿瘤坏死因子-α（TNF-α）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）以及白细胞介素-8（IL-8）含量的变化。
结果多发伤患者治疗组平均住院时间及平均住ICU时间均低于对照组，差异有显著性意义（P＜0.05）；治疗组术后血浆ALT、AST、BUN及Scr浓度均明显低于对照组（P＜0.05）；治疗组术后血浆TNF-α水平逐渐降低，对照组维持在较高水平； IL-2、IL-6及IL-8水平低于对照组（P＜0.05）。
结论乌司他丁对多发伤有治疗作用，并能减轻机体的全身炎症反应程度，有保护和改善肝、肾功能的作用。

Citation： 赵英萍,李超,廖琼,张爽. Clinical Observation of Ulinastatin for the Treatment Multiple Injuries. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 613-615. doi: Copy

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1. 刘维永，蒋耀光. 胸部创伤 [M]. 长春: 吉林科学技术出版社, 1999∶40～48.
2. 潘成，虞惠康，罗月娥. 注射用乌司他丁 [Ｊ]. 中国新药杂志， 2000； 9（2）∶123.
3. Ayala A, Perrin MM, Meldrum DR，et al. Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin [J]. Cytokine, 1990; 2(3)∶170.
4. 王家顺，李劲松，瞿伟．乌司他丁抗手术侵袭临床报告 [Ｊ].临床外科杂志， 2000； 8（4）∶229.
5. Endo S, Kasai T, Inada K. Evaluation of procalcitonin levels in patients with systemic inflammatory response syndrome as the diagnosis of infection and the severity of illness [Ｊ].Kansenshogaku Zasshi, 1999; 73(3)∶197.
6. Hamazaki K, Matsubara N, Yunoki Y, et al.Effects of ulinastatin on polymorphonuclear leukocyte elastase and interleukin 6 levels after hepatectomy [Ｊ]. Clin Ther， 1994; 16(4)∶680.
7. Shikimi T, Kaku K, Uegaki J, et al. Serum contents of the free forms of alpha(1)microglobulin and ulinastatin: relation to diseased states in patients with mood disorders [Ｊ].Neuropsychobiology, 2001; 43(3)∶145.
8. Damas P, Canivet JL, de Groote D, et al. Sepsis and serum cytokine concentrations [Ｊ]. Crit Care Med, 1997; 25(3)∶405.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Observation of Ulinastatin for the Treatment Multiple Injuries

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