Studies and Advances of Rational Extent of Lymphadenectomy in Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHENG Liyang ¹ , ZHONG Shizhen ¹ , HUANG Zonghai ²

Institute of Clinical Anatomy, The First Military Medical University, Guangzhou 510515, China;

Corresponding author：

Keywords：

Gastric neoplasm; Lymphadenectomy; Sentinel lymph node

Video：

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Objective To summarize and analyze the different views on the extent of lymphadenectomy in gastric cancer, and ways or methods to dissolve the disagreements. Methods The reports and advances on lymphadenectomy in gastric carcinomas were collected and reviewed.
Results Eastern and western scholars presented different view on lymph nodes dissection in gastric cancers because of the difference in nationalty,studying method and operating technique.
Conclusion Although extended lymph node dissection for gastric cancers are supported by more and more reports, it is difficult to evaluate the role exactly. Searchers over the world should learn from each other and explore further in order to develop guiding principles in the end.

Citation： CHENG Liyang,ZHONG Shizhen,HUANG Zonghai. Studies and Advances of Rational Extent of Lymphadenectomy in Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(6): 629-632. doi: Copy

1.	Korenaga D, Baba H, Kakeji Y, et al. Comparison of R1 and R2 gastrectomy for gastric cancer in patients over 80 years of age [J].Surg Oncol, 1991; 48(2)∶136.
2.	Maruyama K, Sasako M, Kinoshita T,et al. Should systematic lymph node dissection be recommended for gastric cancer？ [J].Eur J Cancer, 1998; 34(10)∶1480.
3.	詹文华，郑章清，唐光佐. 根Ⅰ式和根Ⅱ式胃切除术治疗进展期胃癌的比较 [J].中山医科大学学报， 1995； 16(2)∶79.
4.	Roukos DH. Extended lymphadenectomy in gastric cancer: when, for whom and why [J]. Ann R Coll Surg Engl, 1998; 80(1)∶16.
5.	Dent DM, Madden MV, Price SK. Randomized comparison of R1 and R2 gastrectomy for gastric carcinoma [J].Br J Surg, 1988; 75(2)∶110.
6.	Dent DM, Madden MV, Price SK. Controlled trials and the R1/R2 controversy in the management of gastric carcinoma [J]. Surg Oncol Clin North Am, 1993; 2(3)∶433.
7.	Cushieri A, Weeden S, Field J, et al. Patient survival after D1 and D2 resections for gastric cancer: longterm results of the MRC randomized surgical trial. Surgical Cooperative Group [J]. Br J Cancer, 1999; 79(9-10)∶1522.
8.	Bonenkamp JJ, Hermans J, Sasako M,et al. Extended lymphnode dissection for gastric cancer. Dutch Gastric Cancer Group [J]. N Engl J Med, 1999; 340(12)∶908.
9.	Robertson CS, Chung SC, Woods SD, et al. A prospective,randomized trial comparing R1 subtotal gastrectomy with R3 total gastrectomy for antral cancer [J]. Ann Surg, 1994; 220(2)∶176.
10.	Gervasoni JE, Taneja C, Chung MA, et al. Biologic and clinical significance of lymphadenectomy [J]. Surg Clin North Am, 2000; 80(6)∶1631.
11.	詹文华. 推广规范化的胃癌淋巴结清扫术 [J]. 世界华人消化杂志, 1999； 7（12）∶1013.
12.	陈峻青.胃癌外科治疗的纷争、对策及新进展 [J]. 中国实用外科杂志, 2001； 21（7）∶386.
13.	刘允怡.胃癌外科治疗的西方国家意见 [J]. 中国实用外科杂志, 2001； 21（7）∶388.
14.	Soga J, Ohyama S, Miyashita K, et al. A statistical evaluation of advancement in gastric cancer surgery with special reference to the significance of lymphadenectomy for cure [J]. World J Surg, 1988; 12(3)∶398.
15.	Moynihan BGA. The surgical treatment of cancer of the sigmoid flexure and rectum [J]. Surg Gynecol Obstet, 1908; 6(5)∶463.
16.	Halsted WS. The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894 [J]. Johns Hopkins Hosp Rep, 1894; 4(2)∶297.
17.	Paget S. The distribution of secondary growths in cancer of the breast [J]. Lancet, 1889; 1(6)∶571.
18.	Braun S, Pantel K, Muller P, et al. Cytokeratinpositive cells in the bone marrow and survival of patients with stage Ⅰ,Ⅱ,or Ⅲ breast cancer [J]. N Engl J Med, 2000; 342(8)∶525.
19.	Fisher B, Fisher ER. The interrelationship of hematogenous and lymphatic tumor cell dissemination [J]. Surg Gynecol Obstet , 1966; 122(4)∶791.
20.	Koscielny S, Tubiana M, Le MG, et al. Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination [J]. Br J Cancer, 1984; 49(6)∶709.
21.	Seto Y, Nagawa H, Muto T. Results of extended lymph node dissection for gastric cancer cases with N2 lymph node metastasis [J]. Int Surg, 1997; 82(3)∶257.
22.	Dijkstra B, Hill A, Kelly L, et al.The value of sentinel node mapping for staging melanoma [J]. Ir Med J, 2001; 94(7)∶210.
23.	Keshtgar MRS, Ell PJ. Clinical role of sentinellymphnode biopsy in breast cancer [J]. Lancet Oncol, 2002; 3(2)∶105.
24.	Roumen RM, Kuijt GP, Liem IH, et al.Treatment of 100 patients with sentinel nodenegative breast cancer without further axillary dissection [J].Br J Surg, 2001; 88(12)∶1639.
25.	BeecheyNewman N. Sentinel node biopsy: a revolution in the surgical management of breast cancer? [J].Cancer Treat Rev, 1998; 24(3)∶185.
26.	Ichikura T, Morita D, Uchida T, et al. Sentinel node concept in gastric carcinoma [J]. World J Surg, 2002; 26(3)∶318.
27.	Aikou T, Higashi H, Natsugoe S, et al. Can sentinel node navigation surgery reduce the extent of lymph node dissection in gastric cancer？ [J].Ann Surg Oncol, 2001; 8(9 Suppl)∶90S.
28.	Hiratsuka M, Miyashiro I, Ishikawa O, et al. Application of sentinel node biopsy to gastric cancer surgery [J].Surgery, 2001; 129(3)∶335.

1. Korenaga D, Baba H, Kakeji Y, et al. Comparison of R1 and R2 gastrectomy for gastric cancer in patients over 80 years of age [J].Surg Oncol, 1991; 48(2)∶136.
2. Maruyama K, Sasako M, Kinoshita T,et al. Should systematic lymph node dissection be recommended for gastric cancer？ [J].Eur J Cancer, 1998; 34(10)∶1480.
3. 詹文华，郑章清，唐光佐. 根Ⅰ式和根Ⅱ式胃切除术治疗进展期胃癌的比较 [J].中山医科大学学报， 1995； 16(2)∶79.
4. Roukos DH. Extended lymphadenectomy in gastric cancer: when, for whom and why [J]. Ann R Coll Surg Engl, 1998; 80(1)∶16.
5. Dent DM, Madden MV, Price SK. Randomized comparison of R1 and R2 gastrectomy for gastric carcinoma [J].Br J Surg, 1988; 75(2)∶110.
6. Dent DM, Madden MV, Price SK. Controlled trials and the R1/R2 controversy in the management of gastric carcinoma [J]. Surg Oncol Clin North Am, 1993; 2(3)∶433.
7. Cushieri A, Weeden S, Field J, et al. Patient survival after D1 and D2 resections for gastric cancer: longterm results of the MRC randomized surgical trial. Surgical Cooperative Group [J]. Br J Cancer, 1999; 79(9-10)∶1522.
8. Bonenkamp JJ, Hermans J, Sasako M,et al. Extended lymphnode dissection for gastric cancer. Dutch Gastric Cancer Group [J]. N Engl J Med, 1999; 340(12)∶908.
9. Robertson CS, Chung SC, Woods SD, et al. A prospective,randomized trial comparing R1 subtotal gastrectomy with R3 total gastrectomy for antral cancer [J]. Ann Surg, 1994; 220(2)∶176.
10. Gervasoni JE, Taneja C, Chung MA, et al. Biologic and clinical significance of lymphadenectomy [J]. Surg Clin North Am, 2000; 80(6)∶1631.
11. 詹文华. 推广规范化的胃癌淋巴结清扫术 [J]. 世界华人消化杂志, 1999； 7（12）∶1013.
12. 陈峻青.胃癌外科治疗的纷争、对策及新进展 [J]. 中国实用外科杂志, 2001； 21（7）∶386.
13. 刘允怡.胃癌外科治疗的西方国家意见 [J]. 中国实用外科杂志, 2001； 21（7）∶388.
14. Soga J, Ohyama S, Miyashita K, et al. A statistical evaluation of advancement in gastric cancer surgery with special reference to the significance of lymphadenectomy for cure [J]. World J Surg, 1988; 12(3)∶398.
15. Moynihan BGA. The surgical treatment of cancer of the sigmoid flexure and rectum [J]. Surg Gynecol Obstet, 1908; 6(5)∶463.
16. Halsted WS. The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894 [J]. Johns Hopkins Hosp Rep, 1894; 4(2)∶297.
17. Paget S. The distribution of secondary growths in cancer of the breast [J]. Lancet, 1889; 1(6)∶571.
18. Braun S, Pantel K, Muller P, et al. Cytokeratinpositive cells in the bone marrow and survival of patients with stage Ⅰ,Ⅱ,or Ⅲ breast cancer [J]. N Engl J Med, 2000; 342(8)∶525.
19. Fisher B, Fisher ER. The interrelationship of hematogenous and lymphatic tumor cell dissemination [J]. Surg Gynecol Obstet , 1966; 122(4)∶791.
20. Koscielny S, Tubiana M, Le MG, et al. Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination [J]. Br J Cancer, 1984; 49(6)∶709.
21. Seto Y, Nagawa H, Muto T. Results of extended lymph node dissection for gastric cancer cases with N2 lymph node metastasis [J]. Int Surg, 1997; 82(3)∶257.
22. Dijkstra B, Hill A, Kelly L, et al.The value of sentinel node mapping for staging melanoma [J]. Ir Med J, 2001; 94(7)∶210.
23. Keshtgar MRS, Ell PJ. Clinical role of sentinellymphnode biopsy in breast cancer [J]. Lancet Oncol, 2002; 3(2)∶105.
24. Roumen RM, Kuijt GP, Liem IH, et al.Treatment of 100 patients with sentinel nodenegative breast cancer without further axillary dissection [J].Br J Surg, 2001; 88(12)∶1639.
25. BeecheyNewman N. Sentinel node biopsy: a revolution in the surgical management of breast cancer? [J].Cancer Treat Rev, 1998; 24(3)∶185.
26. Ichikura T, Morita D, Uchida T, et al. Sentinel node concept in gastric carcinoma [J]. World J Surg, 2002; 26(3)∶318.
27. Aikou T, Higashi H, Natsugoe S, et al. Can sentinel node navigation surgery reduce the extent of lymph node dissection in gastric cancer？ [J].Ann Surg Oncol, 2001; 8(9 Suppl)∶90S.
28. Hiratsuka M, Miyashiro I, Ishikawa O, et al. Application of sentinel node biopsy to gastric cancer surgery [J].Surgery, 2001; 129(3)∶335.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Studies and Advances of Rational Extent of Lymphadenectomy in Gastric Cancer

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