HE Yujun 1 , HE Shuangwu 1 , GAN Quan 2
  • Department of General Surgery,Daping Hospital and The Research Institute of Surgery,The Third Military Medical University,Chongqing 400042, China;
Colorectal carcinoma; Proliferating cell nuclear antigen; Argyrophilia nucleolar organizer regions
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

ObjectiveTo study the expression and significance of proliferating cell nuclear antigen (PCNA) and argyrophilia nucleolar organizer regions (AgNORs) in colorectal carcinoma (CRC) and carcinoma adjacent mucosa (CAM).MethodsThe expression of PCNA in 48 cases of colorectal carcinoma tissue, CAM and 10 cases of normal mucosa was detected by immunohistochemistry techniques. AgNORs was determined with argyrophilia stain. ResultsThe PCNAlabeling index (PCNALI) and AgNORs count in CRC were higher than that in CAM and normal mucosa(P＜0.01).The PCNALI in Dukes C and D stage was higher than that in Dukes A(P＜0.05). The AgNORs count in 3 cmCAM was higher than 6 cmCAM (P＜0.01) and normal mucosa(P＜0.05). ConclusionSome cells proliferative activity were abnormal in CAM. It indicates that CAM is in an unstable premalignant state, which might have some correlation with the relapse of colorectal carcinoma.

Citation： HE Yujun,HE Shuangwu,GAN Quan. The Clinical Study of PCNA and AgNORs in Colorectal Carcinoma and Carcinoma Adjacent Mucosa. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 108-110. doi: Copy